scholarly journals Is ceftriaxone effective in experimental brain ischemia/reperfusion injury?

2020 ◽  
Vol 121 (12) ◽  
pp. 858-863
Author(s):  
E. Arslan ◽  
M. O. Biyik ◽  
M. Kosucu ◽  
A. R. Guvercin ◽  
A. Bodur ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Brain Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion

scholarly journals Neuroprotective Effects of Mitochondria-Targeted Plastoquinone and Thymoquinone in a Rat Model of Brain Ischemia/Reperfusion Injury

Molecules ◽  
2015 ◽  
Vol 20 (8) ◽  
pp. 14487-14503 ◽  
Author(s):  
Denis Silachev ◽  
Egor Plotnikov ◽  
Ljubava Zorova ◽  
Irina Pevzner ◽  
Natalia Sumbatyan ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Brain Ischemia ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Neuroprotective Effects

scholarly journals Cannabinoid CB1 receptor agonist ACEA alleviates brain ischemia/reperfusion injury via CB1–Drp1 pathway

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Shuai Yang ◽  
Bin Hu ◽  
Zongming Wang ◽  
Changming Zhang ◽  
Haosen Jiao ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Brain Ischemia ◽  
Receptor Agonist ◽  
Ischemia Reperfusion Injury ◽  
Infarct Volume ◽  
Ischemia Reperfusion ◽  
Mitochondrial Fission ◽  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor ◽  
Neuroprotective Effects

Abstract Activation of the cannabinoid CB1 receptor induces neuroprotection against brain ischemia/reperfusion injury (IRI); however, the mechanism is still unknown. In this study, we used oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury in neuronal cells and middle cerebral artery occlusion (MCAO)-induced brain IRI in rats to mimic ischemic brain injury, and hypothesized that the CB1 receptor agonist arachidonyl-2-chloroethylamide (ACEA) would protect ischemic neurons by inhibiting mitochondrial fission via dynamin-related protein 1 (Drp1). We found that OGD/R injury reduced cell viability and mitochondrial function, increased lactate dehydrogenase (LDH) release, and increased cell apoptosis, and mitochondrial fission. Notably, ACEA significantly abolished the OGD/R-induced neuronal injuries described above. Similarly, ACEA significantly reversed MCAO-induced increases in brain infarct volume, neuronal apoptosis and mitochondrial fission, leading to the recovery of neurological functions. The neuroprotective effects of ACEA were obviously blocked by coadministration of the CB1 receptor antagonist AM251 or by the upregulation of Drp1 expression, indicating that ACEA alleviates brain IRI via the CB1–Drp1 pathway. Our findings suggest that the CB1 receptor links aberrant mitochondrial fission to brain IRI, providing a new therapeutic target for brain IRI treatment.

scholarly journals Neuroprotective effects of consuming bovine colostrum after focal brain ischemia/reperfusion injury in rat model

2010 ◽  
Vol 4 (3) ◽  
pp. 196 ◽  
Author(s):  
Han Sung Choi ◽  
Young Gwan Ko ◽  
Jong Seok Lee ◽  
Oh Young Kwon ◽  
Sun-Kyu Kim ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Brain Ischemia ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Bovine Colostrum ◽  
Neuroprotective Effects ◽  
Focal Brain Ischemia

scholarly journals Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury

2014 ◽  
Vol 67 ◽  
pp. 57-70 ◽  
Author(s):  
Nikola Sladojevic ◽  
Svetlana M. Stamatovic ◽  
Richard F. Keep ◽  
Jamison J. Grailer ◽  
J. Vidya Sarma ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Adhesion Molecule ◽  
Brain Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Leukocyte Trafficking

Glucosamine exerts a neuroprotective effect via suppression of inflammation in rat brain ischemia/reperfusion injury

Glia ◽  
2010 ◽  
Vol 58 (15) ◽  
pp. 1881-1892 ◽  
Author(s):  
So-Young Hwang ◽  
Joo-Hyun Shin ◽  
Ji-Sun Hwang ◽  
Song-Yi Kim ◽  
Jin-A Shin ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Brain ◽  
Brain Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Neuroprotective Effect ◽  
Ischemia Reperfusion
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