scholarly journals A new platform for drug discovery

2019 ◽  
Vol 1 (2) ◽  
pp. FDD20
Author(s):  
Tuomas PJ Knowles

Professor Tuomas Knowles gained his PhD in biophysics from the University of Cambridge (UK) in 2007 and went on to work at Harvard University (MA, USA) before returning to Cambridge as a lecturer, gaining professorship in 2015. He is the founder and Chief Scientific Officer of Fluidic Analytics (Cambridge, UK), a biotech company developing next-generation protein analysis platforms that operate under native conditions in solution. Here he speaks to Future Drug Discovery Editor Jennifer Straiton about Fluidic Analytics' new platform Fluidity One-W, discussing how it works and what benefit it can bring to the field of drug discovery.

2015 ◽  
Vol 53 (3) ◽  
pp. 681-682

Bruno S. Sergi of University of Messina and Harvard University reviews “The Philosophy, Politics and Economics of Finance in the 21st Century: From Hubris to Disgrace”, by Patrick O'Sullivan, Nigel F. B. Allington, and Mark Esposito. The Econlit abstract of this book begins: “Twenty-four papers explore topics regarding the philosophy, politics, and economics of finance and present insights into the workings of contemporary finance and its regulation in the early twenty-first century. Papers discuss the nadir of 2008 and its aftermath; asset management—some considerations on performance; risk in the age of crises; financialization; whether Islamic finance is a complement to conventional western finance—underlying principles and viability; stakeholder expectation and its role in decision making in the financial sector; the impact of the subprime financial crisis on the Eastern European transition economies, and why Poland is an outlier; China as cause and victim of the US subprime crisis—the crisis and its impact on China and the Asian economies; default invariance—a naive category theory of law and finance; why Europe needs the liberal Keynes; neologism as theoretical innovation in economics—the case of “financialization”; ethics—from negative regulations to fidelity to the event; the bank, its societal functions, and its practices—conflictual relationships between an economic agent and democracy; the sufficiency economy—a Thai response to financial excesses; ethics should not cloud business or financial decisions—the enduring power of the neoclassical paradigm; regulation and fraud—a critical assessment of accounting information, corporate governance, and complex systems of business control; the psychology of unethical behavior in the finance industry; financial liberalism and new institutional environment—the 2007-08 financial crisis as a (de)regulatory deadlock; naturalizing techniques and naturalized discourses—thoughts on the media's role in the Great Recession; initially less obvious areas where financial interests and pressures are exercising a subtle and perhaps more ideologically charged influence on private or public policy choices; thinking well about financial ethics; developing country perspectives—a look at the Nigerian banking sector crisis; theological and historical perspectives on contemporary accounting; and where finance is headed and how finance and its role in the economy ought ideally to evolve.” O'Sullivan is Professor of Business Ethics and Corporate Social Responsibility at Grenoble École de Management and the University of Warsaw. Allington is Professor of Applied Macroeconomics at Grenoble École de Management and Fellow and Director of Studies in Economics in Downing College at the University of Cambridge. Esposito is Associate Professor of Business and Economics at Grenoble École de Management, a member of the teaching faculty at the Harvard University Extension School, and Senior Associate at the University of Cambridge-CISL.


2020 ◽  
Vol 42 (4) ◽  
pp. 58-59

Daniel Jamieson is the CEO and Founder of Biorelate, a biomedical curation company that aims to accelerate insights and innovation in future drug discovery. Daniel started Biorelate in the midst of a computational biology PhD at the University of Manchester after the successful identification of drug repurposing opportunities with Pfizer. He is now coming up to 7 years into that journey, and his focus remains on turning Biorelate into a world-leading enterprise, helping pioneering companies and researchers in their mission to develop life-saving innovations. The Biochemist spoke to Daniel about the journey so far.


2021 ◽  
Vol 3 (3) ◽  
Author(s):  
Srinivasa Reddy Bonam ◽  
Mahendran Sekar ◽  
Girija S Guntuku ◽  
Sridhar G Nerella ◽  
Krishna M Pawar A ◽  
...  

The recent emergence of COVID-19 influenced the layman’s knowledge of drugs. Although several drugs have been discovered serendipitously, research has moved to the next-generation era of drug discovery. The use of drugs is inevitable and they have become lifesavers in the present era. Although research from different scientific backgrounds has supported the translational research of drug discovery, the prime role of pharmacy has to be remembered. Here we have summarized the role of some important subjects in pharmacy education, which have paved different ways in drug discovery and development.


2012 ◽  
Vol 58 ◽  
pp. 299-325 ◽  
Author(s):  
Richard A. Fortey

Harry Whittington was a palaeontologist of distinction who progressed through academic life from a modest background in the Midlands to become an authority on trilobites, and was the scientist who led the re-evaluation of the Cambrian faunas of the Burgess Shale. His studies of silicified trilobites revealed an array of previously unknown morphological details, and identified larval features of many species for the first time, with implications for the classification of the group as a whole. He recognized patterns in the distribution of Ordovician trilobites that anticipated a revolution in palaeobiogeography after the application of plate tectonic theory to the Lower Palaeozoic. The Burgess Shale project cast new light on the early evolution of complex life on Earth. Whittington had a career of exceptional longevity, which reached its acme long after the age of normal retirement and continued almost without a break to his ninetieth year. He was a professor both at Harvard University and in the University of Cambridge, and inspired a generation of palaeontologists who became well known in their own right. His meticulous reconstructions of Cambrian animals, based on his insistence on facts before speculation, revealed the morphological complexity that was already present in the Cambrian world, especially among arthropods, and provided evidence of curious designs that seemed to be far removed from those of organisms still living. He set the standard for the description and naming of organisms preserved in Konservat-Lagerstätten , those rare occurrences with fossils of soft-bodied organisms. The origination of the major living animal groups by the Cambrian was established by this work, which documented the Cambrian evolutionary ‘explosion’ in detail for the first time.


Imbizo ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 92-98
Author(s):  
Faith Mkwesha

This interview was conducted on 16 May 2009 at Le Quartier Francais in Franschhoek, Cape Town, South Africa. Petina Gappah is the third generation of Zimbabwean writers writing from the diaspora. She was born in 1971 in Zambia, and grew up in Zimbabwe during the transitional moment from colonial Rhodesia to independence. She has law degrees from the University of Zimbabwe, the University of Cambridge, and the University of Graz. She writes in English and also draws on Shona, her first language. She has published a short story collection An Elegy for Easterly (2009), first novel The Book of Memory (2015), and another collection of short stories, Rotten Row (2016).  Gappah’s collection of short stories An Elegy for Easterly (2009) was awarded The Guardian First Book Award in 2009, and was shortlisted for the Frank O’Connor International Short Story Award, the richest prize for the short story form. Gappah was working on her novel The Book of Memory at the time of this interview.


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