THE ASSOCIATION OF GESTATIONAL WEIGHT GAIN AND ADVERSE PREGNANCY OUTCOMES IN WOMEN WITH GESTATIONAL DIABETES MELLITUS

Objective: To explore the association of excessive gestational weight gain (GWG) defined by the Institute of Medicine (IOM) targets and adverse perinatal outcomes in gestational diabetes mellitus (GDM) pregnancies, and whether a modified target might be related to a lower rate of adverse perinatal outcomes for GDM. Methods: This retrospective cohort study involved 1,138 women of normal glucose tolerance (NGT) and 1,200 women with GDM. Based on the IOM target, pregnancies were classified to appropriate GWG (aGWG), inadequate GWG, and excessive GWG (eGWG). Modified GWG targets included: upper limit of IOM target minus 1 kg (IOM-1) or 2 kg (IOM-2), both upper and lower targets minus 1 kg (IOM-1-1) or 2 kg (IOM-2-2). Results: The proportions of women achieving eGWG were 26.3% in NGT and 31.2% in GDM ( P = .036); in comparison, for aGWG NGT, the risks of large for gestational age (LGA) were significantly higher in eGWG NGT (adjusted odds ratio [OR] 1.47; 95% confidence interval [CI] 1.02 to 2.13), aGWG GDM (adjusted OR 1.42; 95% CI 1.03 to 1.95), and eGWG GDM (adjusted OR 2.70; 95% CI 1.92 to 3.70). GDM pregnancies gaining aGWG based on the modified GWG targets (IOM-2, IOM-1-1, and IOM-2-2) had a lower prevalence of LGA and macrosomia delivery than that for similar pregnancies using the original IOM target (all P<.05). Conclusion: For aGWG GDM according to the IOM target, adhering to a more stringent weight control was associated with decreased adverse outcomes. A tighter IOM target might help to reduce the prevalence of adverse pregnancy outcomes. Abbreviations: aGWG = appropriate gestational weight gain; BG = blood glucose; BMI = body mass index; CI = confidence interval; eGWG = excessive gestational weight gain; GDM = gestational diabetes mellitus; GW = gestational weeks; GWG = gestational weight gain; HbA1c = hemoglobin A1c; iGWG = inadequate gestational weight gain; IOM = Institute of Medicine; LGA = large for gestational age; NGT = normal glucose tolerance; NICU = neonatal intensive care unit; OGTT = oral glucose tolerance test; OR = odds ratio; PARp = partial population attributable risks; SGA = small for gestational age

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Associations between maternal triclosan concentrations in early pregnancy and gestational diabetes mellitus, impaired glucose tolerance, gestational weight gain and fetal markers of metabolic function

Environmental Research ◽

10.1016/j.envres.2017.12.001 ◽

2018 ◽

Vol 161 ◽

pp. 554-561 ◽

Cited By ~ 7

Author(s):

Gabriel D. Shapiro ◽

Tye E. Arbuckle ◽

Jillian Ashley-Martin ◽

William D. Fraser ◽

Mandy Fisher ◽

...

Keyword(s):

Diabetes Mellitus ◽

Weight Gain ◽

Gestational Diabetes ◽

Glucose Tolerance ◽

Gestational Diabetes Mellitus ◽

Impaired Glucose Tolerance ◽

Gestational Weight Gain ◽

Early Pregnancy ◽

Metabolic Function ◽

Gestational Weight

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Gestational weight gain targets during the second and third trimesters of pregnancy for women with gestational diabetes mellitus in China

European Journal of Clinical Nutrition ◽

10.1038/s41430-018-0358-9 ◽

2018 ◽

Vol 73 (8) ◽

pp. 1155-1163 ◽

Cited By ~ 3

Author(s):

Jiang-Nan Wu ◽

Wei-Rong Gu ◽

Xi-Rong Xiao ◽

Yi Zhang ◽

Xiao-Tian Li ◽

...

Keyword(s):

Diabetes Mellitus ◽

Weight Gain ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Gestational Weight Gain ◽

Gestational Weight

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445: The relationship between gestational weight gain and gestational diabetes mellitus

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2014.10.491 ◽

2015 ◽

Vol 212 (1) ◽

pp. S229

Author(s):

Amy O'Higgins ◽

Lisa O'Higgins ◽

Anne Fennessy ◽

Thomas McCartan ◽

Laura Mullaney ◽

...

Keyword(s):

Diabetes Mellitus ◽

Weight Gain ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Gestational Weight Gain ◽

Gestational Weight ◽

The Relationship

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The impact of restricted gestational weight gain by dietary intervention on fetal growth in women with gestational diabetes mellitus

Diabetologia ◽

10.1007/s00125-018-4736-6 ◽

2018 ◽

Vol 61 (12) ◽

pp. 2528-2538 ◽

Cited By ~ 9

Author(s):

Lise L. Kurtzhals ◽

Sidse K. Nørgaard ◽

Anna L. Secher ◽

Vibeke L. Nichum ◽

Helle Ronneby ◽

...

Keyword(s):

Diabetes Mellitus ◽

Weight Gain ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Gestational Weight Gain ◽

Fetal Growth ◽

Dietary Intervention ◽

Gestational Weight ◽

The Impact

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Association of Maternal Serum Zinc, Copper and Magnesium Levels, Pre-pregnancy Body Mass Index and Gestational Weight Gain Patterns With the Risk of Gestational Diabetes Mellitus Among Third-trimester Pregnant Women: a Cross-sectional Study

10.21203/rs.3.rs-262499/v1 ◽

2021 ◽

Author(s):

Masoomeh Gholizadeh ◽

Tohid Rouzitalab ◽

Saeid Ghavamzadeh ◽

Elnaz Daneshzad

Keyword(s):

Diabetes Mellitus ◽

Weight Gain ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Gestational Weight Gain ◽

Serum Zinc ◽

Cross Sectional Study ◽

Cross Sectional ◽

Gestational Weight

Abstract Background: This study sought to evaluate the association between selected micronutrients (zinc, copper, and magnesium), pre-pregnancy BMI, and weight gain during pregnancy with the risk of gestational diabetes mellitus third-trimester pregnant women Urmia, Iran. Methods: This analytic cross-sectional study included 400 pregnant women. The nutritional, demographic, clinical data, and fasting blood samples (selected micronutrients and blood glucose) were evaluated. The data were analyzed using chi-square, independent t-test, and logistic regression tests. Results: The prevalence of gestational diabetes mellitus (GDM) was 18%. The OR for GDM was (OR: 0.329; 95% CI: 0.156-0.696) in normal-weight compared to mothers who were obese before pregnancy. Normal serum zinc concentration was associated with 0.413-fold lower rates of developing GDM (95% CI: 0.227-0.750). Magnesium supplementation was inversely associated with the risk of GDM (OR: 0.986; 95% CI: 0.979-0.994). Inadequate and excessive gestational weight gain was significantly associated with developing GDM in lean and obese women before pregnancy, respectively (p=0.01, p=0.003). Conclusions: Gestational diabetes is highly prevalent in Urmia, and it is likely related to excessive serum zinc concentrations, elevated pre-pregnancy BMI, and gestational weight gain.

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Maternal genetic contribution to pre-pregnancy obesity, gestational weight gain, and gestational diabetes mellitus

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-019-0434-x ◽

2019 ◽

Vol 11 (1) ◽

Cited By ~ 2

Author(s):

Selvihan Beysel ◽

Nilnur Eyerci ◽

Mustafa Ulubay ◽

Mustafa Caliskan ◽

Muhammed Kizilgul ◽

...

Keyword(s):

Diabetes Mellitus ◽

Weight Gain ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Gestational Weight Gain ◽

Genetic Contribution ◽

Gestational Weight

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Gestational Weight Gain Influences Neonatal Outcomes in Women With Obesity and Gestational Diabetes

10.21203/rs.3.rs-607107/v1 ◽

2021 ◽

Author(s):

Ana M Ramos-Levi ◽

Gemma Rodriguez-Carnero ◽

Cristina Garcia-Fontao ◽

Antia Fernandez-Pombo ◽

Paula Andújar-Plata ◽

...

Keyword(s):

Weight Gain ◽

Birth Weight ◽

Gestational Diabetes ◽

Gestational Weight Gain ◽

Gestational Age ◽

Perinatal Outcomes ◽

Large For Gestational Age ◽

Gestational Weight ◽

Increased Risk ◽

The Impact

Abstract Background. Obesity and gestational diabetes mellitus (GDM) are associated to increased risk of perinatal complications and obesity in the offspring. However, the impact of gestational weight gain (GWG) on maternal and fetal outcomes has led to controversial results. Research design and methods. Retrospective study of 220 women with GDM and pre-pregnancy body mass index (BMI) ≥ 30 kg/m2. Pregnant women were classified according to the Institute of Medicine (IOM) recommendations regarding prior BMI and GWG. We evaluated the impact of GWG on birth weight and perinatal outcomes. Results. Mean maternal age was 34.7±5.3 years. Pre-pregnancy obesity was classified as grade I in 55.3% of cases, grade II in 32.0%, and grade III in 12.7%. GWG was adequate (5-9kg) in 24.2%, insufficient (< 5kg) in 41.8% and excessive (> 9kg) in 34.2%. Birthweight was within normal range in 81.9%, 3.6% were small for gestational age (SGA) and 14.4% were large for gestational age (LGA). Insufficient GWG was associated to a higher rate of SGA offspring, excessive GWG was associated to LGA and adequate GWG to normal birth weight. Conclusion. GWG in women with pre-pregnancy obesity and GDM impacts neonatal birthweight. Insufficient GWG is associated to SGA and excessive GWG is associated to LGA. Women with adequate GWG according to IOM guidelines obtained better perinatal outcomes.

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