scholarly journals EGF Induces Cell Motility and Multi-Drug Resistance Gene Expression in Breast Cancer Cells

Cell Cycle ◽  
2006 ◽  
Vol 5 (23) ◽  
pp. 2820-2826 ◽  
Author(s):  
Ruben Garcia ◽  
Richard A. Franklin ◽  
James A. McCubrey
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Drug Resistance ◽  
Cell Motility ◽  
Cancer Cells ◽  
Resistance Gene ◽  
Breast Cancer Cells ◽  
Multi Drug Resistance ◽  
Drug Resistance Gene

scholarly journals An integrative genomic analysis revealed the relevance of microRNA and gene expression for drug-resistance in human breast cancer cells

2011 ◽  
Vol 10 (1) ◽  
pp. 135 ◽  
Author(s):  
Yusuke Yamamoto ◽  
Yusuke Yoshioka ◽  
Kaho Minoura ◽  
Ryou-u Takahashi ◽  
Fumitaka Takeshita ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Genomic Analysis ◽  
Human Breast Cancer Cells ◽  
Human Breast

PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer

2021 ◽  
Author(s):  
xingang wang ◽  
YAN ZHENG ◽  
YU WANG
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Cell Growth ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Multi Drug Resistance ◽  
Cancer Tissues

Abstract Background and AimsPseudopodium-enriched atypical kinase 1 (PEAK1) has reported to be upregulated in human malignancies and related with poor prognosis. Enhanced PEAK1 expression facilitates tumor cell survival, invasion, metastasis and chemoresistance. However, the role of PEAK1 in breast cancer is not clear. Here, we investigated the PEAK1 expression in breast cancer and analyzed its relation with clinicopathological status and chemotherapy resistance to the neoadjuvant chemotherapy (NAC). We also investigated the role of PEAK1 on breast cancer cells in vitro and in vivo. MethodsImmunohistochemistry (IHC) was performed in 112 surgical resected breast cancer tissues. The associations between clinicopathological status, multi-drug resistance and PEAK1 expression were determined. Effect of PEAK1 overexpression or down-expression on proliferation, colony formation, invasion, migration, metastasis and Doxorubicin sensitivity in the MCF-7 cells in vitro and in vivo was detected. ResultsPEAK1 was overexpressed in breast cancer tissues and NAC -resistant breast cancer tissues. High PEAK1 expression was related with tumor size, high tumor grade, T stage, LN metastasis, recurrence, Ki-67 expression, Her-2 expression and multi-drug resistance. Targeting PEAK1 inhibited cell growth, invasion, metastasis and reversed chemoresistance to Doxorubicin in breast cancer cells in vitro and in vivo. ConclusionHigh PEAK1 expression was associated with invasion, metastasis and chemoresistance of breast cancers. Furthermore, targeting PEAK1 could inhibit cell growth and metastasis, and reverse chemoresistance in breast cancer cells, which provides an effective treatment strategies for breast cancer.

Suppression of multi-drug resistance gene expression in the mouse liver by 1,4-bis[2,(3,5-dichloropyridyloxy)]benzene

1994 ◽  
Vol 58 (4) ◽  
pp. 550-554 ◽  
Author(s):  
Alison L. Russell ◽  
Colin J. Henderson ◽  
Gillian Smith ◽  
C. Roland Wolf
Keyword(s):  
Gene Expression ◽  
Drug Resistance ◽  
Resistance Gene ◽  
Mouse Liver ◽  
Multi Drug Resistance ◽  
Drug Resistance Gene

Polymorphic Sites (1236 and 3435) in Multi Drug Resistance Gene 1 Influencing Drug Response in Breast Cancer Patients

2007 ◽  
Vol 3 (6) ◽  
pp. 453-460 ◽  
Author(s):  
Shaswati Khan . ◽  
Kaiser Jamil . ◽  
G. Prabhavathy Das . ◽  
Ch. Mohana Vamsy . ◽  
Sudha Murthy .
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Cancer Patients ◽  
Resistance Gene ◽  
Drug Response ◽  
Multi Drug Resistance ◽  
Breast Cancer Patients ◽  
Drug Resistance Gene

PKD2 mediates multi-drug resistance in breast cancer cells through modulation of P-glycoprotein expression

2011 ◽  
Vol 300 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Jiao Chen ◽  
Libing Lu ◽  
Yun feng ◽  
Hui Wang ◽  
Lila Dai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Multi Drug Resistance ◽  
P Glycoprotein
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