Effects of the Rome IV Criteria to Functional Dyspepsia Symptoms in Saudi Arabia: Epidemiology and Clinical Practice

Aim of review. Interpretation of published evidence on the relationship between the excessive belching syndrome and functional dyspepsia (FD) and their management in patient care.Key points. According to the Rome IV criteria of functional gastrointestinal disorders (FGID), excessive belching in the absence of other dyspeptic symptoms is to be considered a manifestation of the excessive belching syndrome, which can be of gastric or supragastric nature. Combination of high-resolution manometry and impedancemetry allows an accurate diagnosis of belching and selection of optimal treatment strategy. Belching complicated by other symptoms of dyspepsia is to be considered yet another FD symptom according to the Rome IV criteria of FGID. Prokinetics are recommended to relieve belching in such cases.Conclusion. Understanding the relationship between the excessive belching syndrome and FD requires further research.

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Functional gastrointestinal disorders in children: agreement between Rome III and Rome IV diagnoses

European Journal of Pediatrics ◽

10.1007/s00431-021-04013-2 ◽

2021 ◽

Author(s):

Desiree F. Baaleman ◽

Carlos A. Velasco-Benítez ◽

Laura M. Méndez-Guzmán ◽

Marc A. Benninga ◽

Miguel Saps

Keyword(s):

Diagnostic Criteria ◽

Functional Dyspepsia ◽

Functional Gastrointestinal Disorders ◽

Functional Constipation ◽

Final Analysis ◽

Gastrointestinal Disorders ◽

Rome Iii ◽

Sample Characteristics ◽

Irritable Bowel ◽

Rome Iv

AbstractTo evaluate the agreement between the Rome III and Rome IV criteria in diagnosing pediatric functional gastrointestinal disorders (FGIDs), we conducted a prospective cohort study in a public school in Cali, Colombia. Children and adolescents between 11 and 18 years of age were given the Spanish version of the Questionnaire on Pediatric Functional Gastrointestinal Disorders Rome III version on day 0 and Rome IV version on day 2 (48 h later). The study protocol was completed by 135 children. Thirty-nine (28.9%) children were excluded because of not following the instructions of the questionnaire. The final analysis included data of 96 children (mean 15.2 years old, SD ± 1.7, 54% girls). Less children fulfilled the criteria for an FGID according to Rome IV compared to Rome III (40.6% vs 29.2%, p=0.063) resulting in a minimal agreement between the two criteria in diagnosing an FGID (kappa 0.34, agreement of 70%). The prevalence of functional constipation according to Rome IV was significantly lower compared to Rome III (13.5% vs 31.3%, p<0.001), whereas functional dyspepsia had a higher prevalence according to Rome IV than Rome III (11.5% vs 0%).Conclusion: We found an overall minimal agreement in diagnosing FGIDs according to Rome III and Rome IV criteria. This may be partly explained by the differences in diagnostic criteria. However, limitations with the use of questionnaires to measure prevalence have to be taken into account. What is Known:• The Rome IV criteria replaced the previous Rome III criteria providing updated criteria to diagnose functional gastrointestinal disorders (FGIDs).• Differences found between Rome IV and historic Rome III FGID prevalence may have been affected by changes in prevalence over time or differences in sample characteristics. What is New:• We found a minimal agreement between Rome III and Rome IV FGID diagnosis, especially in the diagnoses of functional constipation, irritable bowel syndrome, and functional dyspepsia.• The minimal agreement may be partly explained by changes in diagnostic criteria, but limitations with the use of questionnaires to measure prevalence have to be taken into account.

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Analysis of Postprandial Symptom Patterns in Rome III and Rome IV Subgroups of Functional Dyspepsia Patients

Gastroenterology ◽

10.1016/s0016-5085(17)31306-9 ◽

2017 ◽

Vol 152 (5) ◽

pp. S304

Author(s):

Florencia Carbone ◽

Tim Vanuytsel ◽

Jan F. Tack

Keyword(s):

Functional Dyspepsia ◽

Rome Iii ◽

Symptom Patterns ◽

Rome Iv

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Obstacles in conducting clinical trials in the Saudi Arabia

International Journal of Clinical Trials ◽

10.18203/2349-3259.ijct20174864 ◽

2017 ◽

Vol 4 (4) ◽

pp. 166

Author(s):

Salem D. Al Suwaidan ◽

Aseel S. Alsuwaidan

Keyword(s):

Clinical Trials ◽

Saudi Arabia ◽

Clinical Practice ◽

Clinical Research ◽

Strategic Plan ◽

Good Clinical Practice ◽

European Countries ◽

Regulatory Authorities ◽

Research Institution

Background: Conducting clinical research in accordance with the standards of regulatory authorities and within the guidelines of the good clinical practice (GCP) is a matter of concern. It has been noticed that some increment in the conduction of clinical trials outside USA and European countries in the last two decades. The main objective of this study is to identify the magnitude of some obstacles that affect the conduction of clinical trials in accordance with the GCP.Methods: Developing questionnaire in accordance with the criteria of the GCP would make assessment on how to buildup infrastructure including policy and procedures of the research institution. Recommendation of the study is to perform this questionnaire every other year to assess the progress and development of the research institution.Conclusions: To identify good clinical researchers, what sort of obstacle(s) regarding conducting clinical trials, and from these obstacles how to resolve it and build up infrastructure for the research institution and also to establish the strategic plan for the research institution.

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Analysis of Postprandial Symptom Patterns in Subgroups of Patients With Rome III or Rome IV Functional Dyspepsia

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2019.07.053 ◽

2020 ◽

Vol 18 (4) ◽

pp. 838-846.e3 ◽

Cited By ~ 5

Author(s):

F. Carbone ◽

T. Vanuytsel ◽

J. Tack

Keyword(s):

Functional Dyspepsia ◽

Rome Iii ◽

Symptom Patterns ◽

Rome Iv

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Irritable Bowel Syndrome: assessment of prevalence and risk factors in Saudi University students using Rome IV Criteria

Gastroenterology Insights ◽

10.4081/gi.2019.8239 ◽

2019 ◽

Vol 10 (1) ◽

Author(s):

Ramzi Mohammed Hakami ◽

Erwa Elmakki ◽

Taha Hasanain ◽

Awatef Alnami ◽

Alhussen Khawaji ◽

...

Keyword(s):

Saudi Arabia ◽

Irritable Bowel Syndrome ◽

University Students ◽

Emotional Stress ◽

Cross Sectional Study ◽

Food Intolerance ◽

Cross Sectional ◽

Medical College ◽

Irritable Bowel ◽

Rome Iv

The main objective of this study was to determine the prevalence of Irritable Bowel Syndrome (IBS) and its associated factors among University students in Saudi Arabia, as little is known about this issue in our country. This cross-sectional study was conducted between 13 March and 21 May of the Academic Year 2017-2018 at Jazan University, Saudi Arabia, involving a random sample of 890 students, selected using the stratified multistage method. IBS prevalence was determined using the Rome IV diagnostic Criteria. The overall prevalence of IBS was 8.8%. According to the results of the multivariate logistic regression, the most important independent predictors of IBS were being a student in a medical college (OR = 10.42; 95%CI: 3.45-31.51) and a scientific college (OR = 5.16; 95%CI: 1.64-16.22), cigarettes smoking (OR = 2.74; 95%CI: 1.24-6.07), emotional stress (OR = 2.53; 95%CI: 1.28-5.00), and food intolerance (OR = 2.15; 95%CI: 1.11-4.16). The present study revealed a prevalence rate of 8.8%. The main predictors of IBS were being a medical student, a scientific college student, cigarette smoker, and having emotional stress and food intolerance. No significant association was found between IBS and anxiety and depression.

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