Modification of the insulin signaling by Nigella sativa oil and antidiabetic drugs in streptozotocin-induced diabetic rats

2018 ◽  
Vol 07 ◽  
Author(s):  
Mahmoud Balbaa
Keyword(s):  
Insulin Signaling ◽  
Nigella Sativa ◽  
Diabetic Rats ◽  
Antidiabetic Drugs ◽  
Nigella Sativa Oil

scholarly journals Nigella sativa Oil Potentiates the Effects of Pioglitazone on Long Term Alloxan-Induced Diabetic Rats

2015 ◽  
Vol 16 (2) ◽  
pp. 143-151
Author(s):  
AFM Towheedur Rahman ◽  
Md Saiful Islam ◽  
Md Hazrat Ali ◽  
AHM Khurshid Alam ◽  
Md Aziz Abdur Rahman ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Langerhans Cells ◽  
Nigella Sativa ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Complete Recovery ◽  
Pharmaceutical Journal ◽  
Diabetic Rats ◽  
Nigella Sativa Oil

The present study was designed to investigate the effects of combination of Nigella sativa oil and pioglitazone on long-term alloxan-induced diabetic rats. In short-term (two weeks) alloxan-induced diabetic rats, N. sativa oil (NSO) reduced significant amount of glucose in blood, TC, TG and LDL-C and increased significant amount of HDL-C compared to diabetic rats. However, pathological changes of pancreas’s Islets of Langerhans were observed after long-term (four weeks) induction of alloxan in rats. Administration of NSO recovered Langerhans cells from shrinkage whereas pioglitazone displayed slight recovery. But the combination therapy showed complete recovery of Langerhans cells as compared with diabetic rats. Combination of drugs significantly reduced the TC, TG and LDL-C level as well as increased significant amount of HDL-C level to the normal level. Combination also increased DPPH free radical scavenging activity compared with diabetic rats. The results suggest that treatment with combination therapy was more effective than mono-therapy for preventing diabetes as N. sativa oil potentiates the effects of pioglitazone on long term alloxan-induced diabetic rats. DOI: http://dx.doi.org/10.3329/bpj.v16i2.22296 Bangladesh Pharmaceutical Journal 16(2): 143-151, 2013

scholarly journals A Comparative Study of the Effects of Nigella sativa Oil Gel and Aloe Vera Gel on Wound Healing in Diabetic Rats

2018 ◽  
Vol 23 ◽  
pp. 2515690X1877280 ◽  
Author(s):  
Yunita Sari ◽  
Iwan Purnawan ◽  
Dhadhang Wahyu Kurniawan ◽  
Eman Sutrisna
Keyword(s):  
Wound Healing ◽  
Nigella Sativa ◽  
Wound Care ◽  
Aloe Vera ◽  
Diabetic Rats ◽  
The Other ◽  
Diabetic Ulcers ◽  
Nigella Sativa Oil ◽  
Aloe Vera Gel ◽  
Important Evidence

Clinicians and wound care nurses in Indonesia usually use Nigella sativa oil (NSO) gel and aloe vera (AV) gel to treat diabetic ulcers. However, there are no studies directly comparing the effects of NSO and AV gels on wound healing, so it is unknown which of these 2 plants is better at promoting wound healing in diabetic ulcers. If the comparative efficacy between these 2 gels was known, it would be important evidence favoring the clinical use of one or the other product in Indonesia. The aim of this study was to investigate and compare the effectiveness of NSO and AV gels on wound healing in a rat model of diabetic ulcers. This experimental study involved 3 groups: NSO gel, AV gel, and controls. Our study showed that from day 5 onward, necrotic tissue and inflammation decreased in the AV gel group compared with the other groups. The wound areas on days 6 ( P = .020) and 7 ( P = .021) were significantly smaller in the AV gel group than in the NSO gel group. Reepithelialization was also better in the AV gel group than in the other groups. This is the first study to compare the effects of AV and NSO gels on wound healing in diabetic ulcers. Our study indicates that the AV gel is better than the NSO gel. Therefore, it is recommended that clinicians and wound care nurses use AV gel instead of NSO gel for the topical treatment of diabetic ulcers.

The protective effect of Nigella Sativa oil extract against neurotoxicity induced by Valproic acid

2017 ◽  
Vol 6 (9) ◽  
pp. 5474 ◽  
Author(s):  
Basant Mahmoud Morsy ◽  
Ghada Mohamed Safwat ◽  
Doaa Ahmed Hussein ◽  
Reem Mohamed Samy
Keyword(s):  
Valproic Acid ◽  
Nigella Sativa ◽  
Liver Lipid ◽  
Black Cumin ◽  
Enzymatic Antioxidant ◽  
Nigella Sativa Oil ◽  
Active Chemical ◽  
Oil Extract ◽  
Liver Lipid Peroxidation

Nigella sativa (NS), commonly known as black cumin, has been used for medicinal purposes. Traditionally the seeds and its oil are used in several diseases. The greatest part of the remedial properties of this plant is due to the presence of thymoquinone (TQ) which is a major active chemical component of the essential oil. The current study performed to evaluate the effect of Nigella sativa Oil (NSO) extract on the neurotoxic and hepatotoxic potentials from Valproic acid (VPA) administration. Also we summarize recent findings emphasizing the role of main neurotoxic and hepatotoxic markers and oxidative stress in study’s case. Neurotoxicity was induced by VPA at dose of (500 mg/kg b.wt) by gastric intubation daily for 30 day. These rats received NSO extract was given orally at dose of (0.5 ml/kg b.wt) daily for 30 days after VPA administration. The current results revealed that NSO extract treatment ameliorated significantly the elevated levels of the neurotoxic and hepatotoxic biomarkers which elevated as a result to VPA administration. Moreover, NSO extract treatment ameliorated the non-enzymatic antioxidant, brain and liver lipid peroxidation (LPO) and glutathione (GSH) concentration and the enzymatic antioxidant, brain and liver catalase(CAT) activity.

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