Flow chemistry- flow analysis vs flow synthesis: Similarities and current trends

2018 ◽  
Vol 06 ◽  
Author(s):  
Marek Trojanowicz
Keyword(s):  
Flow Analysis ◽  
Flow Chemistry ◽  
Flow Synthesis ◽  
Current Trends

scholarly journals Modern Flow Analysis

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2897
Author(s):  
Paweł Kościelniak
Keyword(s):  
Flow Analysis ◽  
Flow Chemistry ◽  
Special Issue ◽  
Good Picture ◽  
Cross Sectional ◽  
Current Trends

A brief overview of articles published in this Special Issue of Molecules titled “Modern Flow Analysis” is provided. In addition to cross-sectional and methodological works, there are some reports on new technical and instrumental achievements. It has been shown that all these papers create a good picture of contemporary flow analysis, revealing the most current trends and problems in this branch of flow chemistry.

Pulsed flow chemistry: a new approach to solution handling for flow analysis coupled with chemiluminescence detection

The Analyst ◽  
2000 ◽  
Vol 125 (10) ◽  
pp. 1869-1874 ◽  
Author(s):  
Simon W. Lewis ◽  
Paul S. Francis ◽  
Kieran F. Lim ◽  
Graeme E. Jenkins ◽  
Xue D. Wang
Keyword(s):  
Flow Analysis ◽  
Flow Chemistry ◽  
Chemiluminescence Detection ◽  
New Approach ◽  
Pulsed Flow

scholarly journals Continuous flow synthesis of phase transition-resistant titania microparticles with tunable morphologies

RSC Advances ◽  
2020 ◽  
Vol 10 (14) ◽  
pp. 8340-8347 ◽  
Author(s):  
Zachary S. Campbell ◽  
Daniel Jackson ◽  
Jacob Lustik ◽  
Amur K. Al-Rashdi ◽  
Jeffrey A. Bennett ◽  
...  
Keyword(s):  
Phase Transition ◽  
Continuous Flow ◽  
High Surface ◽  
Flow Chemistry ◽  
Flow Focusing ◽  
Flow Synthesis ◽  
Surface Areas ◽  
Uv Led ◽  
Anatase Titania

A flow chemistry strategy for synthesis of anatase titania microparticles utilizing a flow-focusing microreactor integrated with a collimated UV LED is presented. The synthesized microparticles possess a wide variety of morphologies and high surface areas (up to 362 m2 g−1).

scholarly journals Combining Radial and Continuous Flow Synthesis to Optimize and Scale-up the Production of Medicines

2021 ◽  
Author(s):  
Mara Guidi ◽  
Soo-Yeon Moon ◽  
Lucia Anghileri ◽  
Dario Cambié ◽  
Peter Seeberger ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Scale Up ◽  
Flow Chemistry ◽  
Essential Medicines ◽  
Flow Synthesis ◽  
Drug Production ◽  
On Demand ◽  
Current Drug

Current drug production in batch cannot adapt rapidly to market demands, evidenced by recent shortages in many markets globally of essential medicines. Flow chemistry is a valuable tool for on-demand...

scholarly journals Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3242 ◽  
Author(s):  
Marco Colella ◽  
Leonardo Degennaro ◽  
Renzo Luisi
Keyword(s):  
Drug Discovery ◽  
Continuous Flow ◽  
Medicinal Chemistry ◽  
Flow Chemistry ◽  
Modern Synthesis ◽  
Indole Derivatives ◽  
Flow Synthesis

Indole derivatives are among the most useful and interesting heterocycles employed in drug discovery and medicinal chemistry. In addition, flow chemistry and flow technology are changing the synthetic paradigm in the field of modern synthesis. In this review, the role of flow technology in the preparation of indole derivatives is showcased. Selected examples have been described with the aim to provide readers with an overview on the tactics and technologies used for targeting indole scaffolds.

Integrating multicomponent flow synthesis and computational approaches for the generation of a tetrahydroquinoline compound based library

MedChemComm ◽  
2016 ◽  
Vol 7 (3) ◽  
pp. 439-446 ◽  
Author(s):  
Bruno Cerra ◽  
Serena Mostarda ◽  
Chiara Custodi ◽  
Antonio Macchiarulo ◽  
Antimo Gioiello
Keyword(s):  
Flow Chemistry ◽  
Multicomponent Flow ◽  
Computational Tools ◽  
Computational Approaches ◽  
Flow Synthesis

The combination of flow chemistry and computational tools has been successfully applied to prepare a focused library of tricyclic tetrahydroquinolines endowed with drug-like properties.

Continuous Flow Synthesis of Coumarin

2013 ◽  
Vol 781-784 ◽  
pp. 936-941 ◽  
Author(s):  
An Bang Chen ◽  
Xin Li ◽  
Yang Zhi Zhou ◽  
Ling Ling Huang ◽  
Zheng Fang ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Chemistry ◽  
Emerging Technology ◽  
High Conversion ◽  
Small Scale ◽  
Flow Synthesis

Flow chemistry, as a rapidly emerging technology, is exploited to provide a safe and scalable route for the pharmaceutically interesting coumarin. Here, a continuous flow approach for the generation of coumarin is reported, which relies on the two connected coil reactors design. The synthesis of coumarin has been performed successfully in high conversion on small scale and can be scaled up substantially.

ChemInform Abstract: Flow Chemistry vs. Flow Analysis

ChemInform ◽  
2016 ◽  
Vol 47 (9) ◽  
pp. no-no
Author(s):  
Marek Trojanowicz
Keyword(s):  
Flow Analysis ◽  
Flow Chemistry

Flow synthesis approaches to privileged scaffolds – recent routes reviewed for green and sustainable aspects

2021 ◽  
Vol 23 (6) ◽  
pp. 2233-2292
Author(s):  
Antonella Ilenia Alfano ◽  
Margherita Brindisi ◽  
Heiko Lange
Keyword(s):  
Green Chemistry ◽  
Flow Chemistry ◽  
Diversity Oriented Synthesis ◽  
Flow Synthesis ◽  
Versatile Tool ◽  
Privileged Scaffolds

This review discusses the use of flow chemistry as versatile tool for the synthesis and derivatisation of privileged scaffolds, looking at applicability, diversity-oriented synthesis options, inherent sustainability and green chemistry aspects.

scholarly journals One-flow synthesis of tetrahydrocannabinol and cannabidiol using homo- and heterogeneous Lewis acids

2021 ◽  
Author(s):  
Victor R. L. J. Bloemendal ◽  
Bram Spierenburg ◽  
Thomas J. Boltje ◽  
Jan C. M. van Hest ◽  
Floris P. J. T. Rutjes
Keyword(s):  
Continuous Flow ◽  
Lewis Acids ◽  
Ring Opening ◽  
Flow System ◽  
Flow Chemistry ◽  
Batch Processes ◽  
Flow Synthesis ◽  
Biologically Relevant ◽  
Continuous Flow Chemistry ◽  
Biologically Relevant Molecules

AbstractContinuous flow chemistry holds great potential for the production of biologically relevant molecules. Herein, we present an approach for the continuous synthesis of cannabidiol and tetrahydrocannabinol in a one-flow system. The designed route consists of a reaction cascade involving Friedel-Crafts alkylation, subsequent ring opening and cyclisation in up to 45% yield. The reactions were successfully performed using both hetero- and homogeneous Lewis acids in continuous flow and provide yields that are similar to comparable batch processes. Graphical abstract

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