Serum Levels of  Interleukin - 23 and Interleukin - 17 in Hashimoto’s Thyroiditis

Abstract. A 36 year old man with a diffuse goitre, signs of mild hypothyroidism, strikingly low levels of T4 (0.9 μg/dl) and T3 (24 ng/dl), elevated TSH (140 μU/ml) and elevated microsomal haemagglutination antibody (MCHA, 1:409 600), subsequently became non-goitrous and euthyroid with a decreased titre of antimicrosomal antibody without any medication. At the time of surgical biopsy, serum levels of T4 and T3 had risen to the normal range (4.6 μg/dl and 73 ng/dl, respectively), serum TSH had decreased to 30 μU/ml and the titre of MCHA to 1:25 600. Thyroid specimens showed Hashimoto's thyroiditis. The activity of thyroid peroxidase (TPO) was normal. The latest examination, 1 year and 3 months after initial evaluation, showed that the patient remained euthyroid with no goitre, that serum thyroid hormones were within the normal range (T4 7.7 μg/dl and T3 97 ng/dl), and that TSH was not detectable. The titre of MCHA decreased strikingly to 1:400.

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Discordance of serological and sonographic markers for Hashimoto’s thyroiditis with gold standard histopathology

Acta Endocrinologica ◽

10.1530/eje-19-0424 ◽

2019 ◽

Vol 181 (5) ◽

pp. 539-544 ◽

Cited By ~ 3

Author(s):

Haixia Guan ◽

Nathalie Silva de Morais ◽

Jessica Stuart ◽

Sara Ahmadi ◽

Ellen Marqusee ◽

...

Keyword(s):

Gold Standard ◽

Hashimoto’S Thyroiditis ◽

Elevated Serum ◽

Serum Levels ◽

Hashimoto's Thyroiditis ◽

Thyroid Ultrasound ◽

Serological Evidence ◽

Histopathologic Analysis ◽

The Impact ◽

Histopathologic Findings

Objective To investigate the concordance of serologic and sonographic evidence of Hashimoto’s thyroiditis with its gold standard histopathologic identification. Design We performed a retrospective analysis on a cohort of 825 consecutive patients in whom TPOAb and thyroid ultrasound were performed, and in whom thyroid nodule evaluation led to surgical and histopathologic analysis. The presence or absence of Hashimoto’s thyroiditis on histopathology was correlated with serologic and sonographic markers. We further assessed the impact of low versus high titers of TPOAb upon this concordance. Results Of 825 patients, 277 (33.5%) had histologic confirmation of Hashimoto’s thyroiditis, 235 patients (28.4%) had elevated serum levels of TPOAb, and 197 (23.8%) had sonographic evidence of diffuse heterogeneity. Of those with histopathologic evidence, only 64% had elevated TPOAb (sensitivity: 63.9%; specificity: 89.4%), while only 49% were sonographically diffusely heterogeneous (sensitivity: 49.1%; specificity: 88.9%). A subset of only 102 of 277 (37%) with histologically proven Hashimoto’s thyroiditis was positive for both TPOAb and diffusely heterogeneous. Concordance analysis demonstrated that TPOAb and histopathology had higher agreement (κ = 0.55) than did ultrasound and histopathology (κ = 0.40) for the diagnosis of Hashimoto’s thyroiditis. Higher titers of TPOAb correlated with a higher likelihood of Hashimoto’s thyroiditis, with a best cutoff of 2.11-fold the upper normal level of TPOAb. Conclusion Only moderate concordance exists between serological evidence of Hashimoto’s thyroiditis and histopathologic findings, though it increases with higher TPOAb concentration. Diffuse heterogeneity on ultrasound is a less-sensitive diagnostic tool than elevated TPOAb.

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Decreased serum levels of interleukin‐17, interleukin‐23, TGF ‐β in pemphigus vulgaris patients, and their association with disease phase

Dermatologic Therapy ◽

10.1111/dth.14071 ◽

2020 ◽

Vol 33 (6) ◽

Author(s):

Zeinab Gholibeigian ◽

Maryam Izad ◽

Maryam Daneshpazhooh ◽

Hossein Mortazavi ◽

Zahra Salehi ◽

...

Keyword(s):

Pemphigus Vulgaris ◽

Serum Levels ◽

Interleukin 17 ◽

Interleukin 23

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Comparison of the sonography index of thyroid gland with serum level of Anti-thyroid peroxidase, Anti-thyroglobulin and thyroid function test in patients with Hashimoto thyroiditis

10.21203/rs.3.rs-835595/v1 ◽

2021 ◽

Author(s):

Fatemeh Eftekharian ◽

Gholamhossein Ranjbar Omrani ◽

Mohammad Hossein Dabbaghmanesh ◽

Reza Sahraei ◽

Marzieh Bakhshayeshkaram ◽

...

Keyword(s):

Thyroid Hormones ◽

Hashimoto’S Thyroiditis ◽

Thyroid Volume ◽

Thyroid Function Test ◽

Serum Levels ◽

Significant Negative Correlation ◽

Thyroid Stimulating Hormone ◽

Hashimoto's Thyroiditis ◽

Thyroid Peroxidase ◽

Antibody Titers

Abstract Background The purpose of this study was to determine the association of sonographic parameters with the serum levels of anti-thyroid peroxidase (TPO), anti-thyroglobulin (Tg), and thyroid hormones in patients with Hashimoto's thyroiditis. Methods 149 patients (118 females, 31 males; aged 18–60 years; mean age: 38.60 ± 8.03 years) who were diagnosed with Hashimoto's thyroiditis were enrolled in the study. Blood sample was taken to measure the serum levels of free T3 and T4, thyroid stimulating hormone (TSH), anti-TPO antibody titers, and anti-Tg antibody titers. The thyroid sonography of each patient was classified into one of the five grades by real-time ultrasonography (US) based on echogenicity, thyroid size, and thyroid pattern. We evaluated whether a correlation existed between thyroid characteristics on US and serum levels of thyroid hormones, anti-TPO and anti-Tg. Results Nodular structures were detected in 54 (36.2%) patients (38 micronodular and 16 macros nodular). Echogenicity was recorded as isoechoic in 15 (10.07%) and hypoechoic in 119 (79.87%) subjects. Euthyroid ‎subjects had significantly thicker isthmus than overt and subclinical hypothyroid patients (p = 0.018). Mean serum TSH, anti-Tg and anti-TPO titers was significantly higher in patients with micronodules than those with micronodules and subjects without nodules (P < 0.05). Isthmus thickness had a significant negative correlation with FT4 and FT3 (P = 0.046; r = 0.11& P = 0.017; r = 0.15, respectively). Thyroid autoantibodies had positive significant correlations with different parameters of the thyroid volume (P < 0.05). Conclusions Thyroid’s US findings in addition to serum levels of anti-Tg and anti-TPO titers would be useful in diagnosis and evaluation of the severity and extent of Hashimoto's thyroiditis, but further evaluations are needed. Trial registration: Trial registry identifier IR.SUMS.REC.1395.S161 (2015/11/30).

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Changes in the serum levels of interleukin-17/interleukin-23 during acute rejection in liver transplantation

Liver Transplantation ◽

10.1002/lt.21724 ◽

2009 ◽

Vol 15 (6) ◽

pp. 629-633 ◽

Cited By ~ 68

Author(s):

Emilio Fábrega ◽

Marcos López-Hoyos ◽

David San Segundo ◽

Fernando Casafont ◽

Fernando Pons-Romero

Keyword(s):

Liver Transplantation ◽

Acute Rejection ◽

Serum Levels ◽

Interleukin 17 ◽

Interleukin 23

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The Effect of Steroid Therapy on Riedel's Thyroiditis

Scottish Medical Journal ◽

10.1177/003693306801300103 ◽

1968 ◽

Vol 13 (1) ◽

pp. 13-16 ◽

Cited By ~ 23

Author(s):

J. A. Thomson ◽

I. M. D. Jackson ◽

W. P. Duguid

Keyword(s):

Family History ◽

Hashimoto’S Thyroiditis ◽

Therapeutic Response ◽

Serum Levels ◽

Clinical State ◽

Hashimoto's Thyroiditis ◽

Thyroid Antibodies ◽

Riedel’S Thyroiditis ◽

History Of ◽

Riedel's Thyroiditis

A patient is described who passed from a clinical state consistent with Hashimoto's thyroiditis to Riedel's thyroiditis over a period of 6 months. Serum levels of thyroid antibodies were high and there was a family history of Hashimoto's thyroiditis. A good therapeutic response to steroids was observed but these were without effect in a further patient with Riedel's thyroiditis of 10 years' duration. It is suggested that Riedel's thyroiditis is an uncommon variant of Hashimoto's thyroiditis.

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