Gestational Trophoblastic Diseases: A Review of the Clinical Presentation and Management at the Alex Ekwueme Federal University Teaching Hospital Abakaliki

Background: Gestational Trophoblastic Diseases (GTD) encompass a wide spectrum of proliferative disorders of trophoblast tissue, which hold a good prognosis if diagnosed and treated on time. A close understanding of the disease spectrum is therefore needed to reduce morbidity and mortality.Methods: This is an observational study (both prospective and retrospective analysis) conducted in Rajendra Institute of Medical Sciences, a tertiary care teaching hospital in Ranchi, Jharkhand over a period of 2 years from 1st January 2017 to 31st December 2018.Results: A total of 162 cases of GTD were identified during the study period. Disease spectrum comprised of complete molar pregnancy in 146 (90.12%) and partial molar pregnancy in 7 (4.3%), GTN in 9 out of 162 cases (5.5%). Bleeding per vaginum preceded by amenorrhea was the most common symptom, observed in 95.4% of the cases. Uterine size was more than period of amenorrhea in almost 50% of the cases. Theca lutein cysts were found in 39.8% of the cases, hypertension in 21.5%, hyperthyroidism in 6.5% cases. Overall, there were nine (5.56%) cases of choriocarcinoma and six (3.7%) cases of Invasive mole. Remission rate in GTN was 86.7% with chemotherapy.Conclusions: Women complaining of vaginal bleeding in first half of pregnancy with uterine size more than period of amenorrhea must be evaluated for GTD by ultrasound and serum beta HCG. For cases of molar pregnancies, suction and evacuation remains the treatment of choice but need for regular follow-up and strict compliance to contraception during entire follow up has to be emphasized. Cases of GTN have excellent remission with chemotherapy.

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Methotrexate in the Treatment of Recalcitrant Nodular Vasculitis

Journal of Nepal Medical Association ◽

10.31729/jnma.2751 ◽

2015 ◽

Vol 53 (200) ◽

pp. 298-300 ◽

Cited By ~ 1

Author(s):

Sudip Parajuli ◽

Kamal Raj Dhital

Keyword(s):

Case Report ◽

Teaching Hospital ◽

Clinical Presentation ◽

University Teaching ◽

Histopathological Findings ◽

Systemic Corticosteroids ◽

Antituberculosis Treatment ◽

Nodular Vasculitis ◽

Patient Department

We report a case of recalcitrant nodular vasculitis in a 23 years old male who was treated successfully with methotrexate. He presented to our Dermatology out Patient Department, Tribhuvan university teaching hospital with complaints of recurrent painful discharging ulcer over bilateral calf and lower legs of three years duration. The diagnosis of nodular vasculitis was made on the basis of the clinical presentation and the histopathological findings. The patient was treated with antituberculosis treatment with initial good response; however the lesions persisted later on, despite completing the course of ATT. The patient did not respond to treatment with systemic corticosteroids also. On starting methotrexate, the lesion started healing within a period of two weeks and therewas significant improvement in subsequent one month. This case report highlights the efficacy of methotrexate in the treatment of recalcitrant nodular vasculitis. Keywords: ATT; methotrexate; nodular vasculitis.

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Coital trauma as seen at Alex Ekwueme Federal University Teaching Hospital Abakaliki, Nigeria

International Journal of Scientific Reports ◽

10.18203/issn.2454-2156.intjscirep20194248 ◽

2019 ◽

Vol 5 (10) ◽

pp. 279

Author(s):

Assumpta Nnenna Nweke ◽

Johnbosco Ifunanya Nwafor ◽

Bridget Nkiruka Uche-Nwidagu ◽

Wendy Chinwe Oliobi ◽

Malachy Chizoba Onyema ◽

...

Keyword(s):

Risk Factors ◽

Retrospective Study ◽

Teaching Hospital ◽

Clinical Presentation ◽

University Teaching ◽

Clinical Notes ◽

Clinical Presentations ◽

Posterior Fornix ◽

The Common ◽

Causes And Risk Factors

Background: Though pleasurable, coitus may result in morbidity and even mortality. One of such morbidities is coital trauma, a global occurrence that is grossly under reported. This study aimed to determine the causes and risk factors for coital trauma as well as its clinical presentation.Methods: This was a 4 year retrospective study of patients that presented with coital injuries at Alex Ekwueme Federal University Teaching Hospital, Abakaliki. Data were obtained from patients’ clinical notes using a specially designed proforma. Statistical analysis was performed using Epi InfoTM 7.2.1. Results: The majority of women that presented with coital trauma were adolescents (67.9%). Most of them were single (92.9%), nulliparous (89.3%) and had only primary education (57.1%). The commonest cause of coital trauma was rape (75%). The commonest risk factors were inadequate foreplay (57.1%) and coitarche (42.9%). Other risk factors were genital disproportion, pregnancy, puerperium and influence of drugs. The common clinical presentations were vaginal bruises (75%) and vaginal lacerations (64.3%) while the commonest site of injury was the hymen (42.9%) followed by the vulva (35.7%). Other less common sites of injury were the lower vagina and posterior fornix.Conclusions: Coital trauma is relatively common and young girls are mainly affected. Rape is the major cause while inadequate foreplay and coitarche are the major predisposing factors.

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Clinical Presentation and Factors Leading to Complications of Deep Neck Spaces Infections at CHUK

Rwanda Journal of Medicine and Health Sciences ◽

10.4314/rjmhs.v4i1.2 ◽

2021 ◽

Vol 4 (1) ◽

pp. 8-19

Author(s):

Isaie Ncogoza ◽

Eric Eric ◽

Jean Paul Mvukiyehe ◽

David Shaye

Keyword(s):

Neck Pain ◽

Hospital Stay ◽

Teaching Hospital ◽

Tooth Extraction ◽

Clinical Presentation ◽

University Teaching ◽

Advanced Age ◽

Categorical Variables ◽

Delayed Presentation ◽

The University

Background Deep neck space infection (DNSI) mostly arise from the local extension of dental, tonsils and parotid gland infections. Early diagnosis and management is the key to avoid associated complications. Objective Our study aimed at evaluating the clinical presentation and factors related to complications of DNSIs at the University Teaching Hospital of Kigali. Methods This cross-sectional study was conducted at the University teaching hospital of Kigali from September 2017 to November 2018. It enrolled 66 participants. Patient information was recorded using a questionnaire and analyzed using Epidata 3.1 software. The data were processed using SPSS 16.0. Comparison of categorical variables were performed using the chi-square test. Associations with p-values=0.05 were considered statistically significant. Results Males accounted for 35 (53%) of DNSIs. The majority (97%) presented with neck pain and 21% with a history of tooth extraction. The submandibular space was the most involved in 33 (50%) cases. The average duration of symptoms at presentation was 11 days. Delayed consultation and advanced age (>40years) were associated with complications and hospital stay with (p value=0.022) and (p=0.015) respectively. Conclusion Neck pain on background of tooth extraction is the most common presentation of patients with DNSIs. Delayed presentation and advanced age are central factors for complications and longer hospital stay. Rwanda J Med Health Sci 2021;4(1):8-19

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INCIDENCE OF TROPHOBLASTIC TUMORS: A RETROSPECTIVE CASE STUDY AT RIMS RANCHI

10.36106/8704789 ◽

2021 ◽

pp. 26-27

Author(s):

Sona Pathak ◽

Suraj Sinha ◽

Md Raihan Md Raihan ◽

M. A. Ansari

Keyword(s):

Clinical Presentation ◽

Hydatidiform Mole ◽

Gestational Trophoblastic Disease ◽

Retrospective Case ◽

Trophoblastic Diseases ◽

Wide Range ◽

Gestational Trophoblastic Diseases ◽

Common Clinical Presentation ◽

Abnormal Vaginal Bleeding ◽

Retrospective Case Study

Background: The gestational trophoblastic diseases encompass a wide range of conditions that vary in their clinical presentation, their propensity for spontaneous resolution, local invasion and metastasis and their overall prognosis. Advanced or adolescent maternal age has consistently correlated with higher rates of complete Hydatidiform mole. Material and Methods: It is a retrospective record based study, performed in Department of pathology RIMS, Ranchi. Study population included all cases which were clinically suspected of gestational trophoblastic disease, with common clinical presentation of abnormal vaginal bleeding, amenorrhea, pain abdomen, from January 2017- December 2020. Results: Hydatidiform mole was found to be the most common form of gestational trophoblastic diseases. Our study shows maximum cases of GTD falls in the age group of 20-29 years followed by 30-39 years.

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