scholarly journals Optimal needle insertion length for intramuscular injection of risperidone long-acting injectable (RLAI)

Health ◽  
2013 ◽  
Vol 05 (12) ◽  
pp. 1939-1945 ◽  
Author(s):  
Tetsuya Tanioka ◽  
Sakiko Sakamaki ◽  
Yuko Yasuhara ◽  
Masahito Tomotake ◽  
Kensaku Takase ◽  
...  
PEDIATRICS ◽  
1985 ◽  
Vol 75 (4) ◽  
pp. 741-744
Author(s):  
Harry Schanzer ◽  
Julius H. Jacobson

In order to elucidate whether tissue damage produced on occasion by intramuscular injection of longacting penicillin is due to accidental intra-arterial injection or vasospasm, two types of experiments were carried out in rabbits. In the first set of experiments, six New Zealand White rabbits were given intra-arterial injections of 0.4 mL of a mixture containing 300,000 U of penicillin G benzathine and 300,000 units of penicillin procaine per milliliter (Bicillin C-R) into the left femoral artery and 0.4 mL of normal saline into the right femoral artery as autocontrol. In a second set of experiments, 0.4 mL of the same penicillin preparation was injected in the space surrounding the left femoral artery in five New Zealand rabbits, and 0.4 mL of normal saline was injected in a similar fashion around the right femotal artery as control. The legs of the rabbits that received the intra-arterial injection of penicillin invariably developed ischemic manifestations. None of the legs of rabbits given intra-arterial injections of normal saline had pathologic manifestations. None of the rabbits that received the periarterial penicillin preparation or normal saline developed abnormalities. These results strongly suggest that the tissue damage produced by penicillin is secondary to the intra-arterial administration of the drug.


Author(s):  
Herana Kamal Seneviratne ◽  
Joseph Tillotson ◽  
Julie M Lade ◽  
Linda-Gail Bekker ◽  
Sue Li ◽  
...  

2014 ◽  
Vol 34 (1) ◽  
pp. 36-45 ◽  
Author(s):  
Yuri Takahashi ◽  
Kazuko Kikuchi ◽  
Natsuko Miura ◽  
Yoko Ishida

2020 ◽  
Vol 45 (5) ◽  
pp. 1098-1105 ◽  
Author(s):  
Ka Lai Yee ◽  
Sachin Mittal ◽  
Li Fan ◽  
Ilias Triantafyllou ◽  
Marissa F. Dockendorf ◽  
...  

2008 ◽  
Vol 47-50 ◽  
pp. 1442-1445
Author(s):  
K.T. Shek ◽  
David C.C. Lam

Drug dosage delivered by drug-coated microneedle is dependent on needle insertion behavior. The insertion length and gripping force at varied insertion speeds are determined quantitatively using a precision test frame. The ratio of inserted depth to pressed depth was found to rise asymptotically to a plateau, but decreased rapidly to zero insertion when the needles are pressed less than 1000 microns deep for both silicone rubber and porcine skin. No insertion was observed when the needles are pressed less than 200 microns. The gripping force exerted onto the inserted needle by the skin decreased by 0.1N per mm of needle diameter and insertion depth. The short insertion depth and low force suggest that drug delivery using short 300 micron microneedles would be tenuous. High insertion speeds can help to improve drug delivery, but the improvement is limited to large needles since the results from this study showed that insertions become speedindependent when the needle diameter is less than 130 microns.


2004 ◽  
Vol 47 (6) ◽  
pp. 575-584 ◽  
Author(s):  
U. Hühn ◽  
T. Udluft ◽  
A. Wehrend ◽  
W. Zaremba

Abstract. Title of the paper: Comparative investigations into the subpartal application of Oxytocin preparations in sows A veterinary supervision and monitoring of the farrowing process was carried out on a weaner production unit comprising of 1,500 sow places with a weekly (7 day) batch farrowing system. Farrowing was recorded as being interrupted in 15.2 % of 1,975 farrowings as a result of inadequate contractions during labour and where the time-interval between the expulsion of consecutive piglets exceeded 40 minutes. 143 affected farrowing sows were allocated into three treatment groups and received an intramuscular injection of 20 I.U. Oxytocin (Group A, n = 44); 140 μg of the agent Carbetocin (contained in 2 ml of the long acting oxytocin preparation Depotocin®; Group B, n = 47) and respectively 70 μg Carbetocin per sow (Group C, n = 52) to stimulate labour contractions. The oxytocin preparation was applied on average 148 minutes following the expulsion of the first piglet. On average 4.2 piglets had been born prior to this point in time. Following the injection of Carbetocin the time required for each piglet to be born, as well as the time to the completion of farrowing, were reduced significantly compared to Group A (p < 0.05) and there was a tendency for a reduction in the proportion of piglets born dead. The various treatments had no fundamental influence on the proportion of those requiring manual assistance at farrowing. The labour contraction inducing injection of 70 μg Carbetocin proved effective; this dosage rate is to be recommended for application during parturition in the pig.


2021 ◽  
Author(s):  
James Hobson ◽  
Alison Savage ◽  
Andrew Dwyer ◽  
Catherine Unsworth ◽  
Usman Arshad ◽  
...  

<p>The spread of SARS-CoV-2 across the world requires the formation of a range of interventions that include immunomodulatory or antiviral therapeutics and repurposing of existing drug compounds is an important strategy to rapidly identify possible options. Niclosamide is a cheap and generic drug compound with a proven <i>in vitro</i> ability to inhibit viral replication of SARS-CoV-2; this drug also has known poor oral bioavailability due to very low water solubility. Here, we demonstrate the nanoparticle formulation of niclosamide using a new, cheap and scalable process to enable long-acting injectable administration and show extended circulating drug exposure <i>in vivo</i> over 28 days using a rodent model after depot injection.</p>


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