scholarly journals Evaluation of the Preventive and Therapeutic Activities of <i>Tridax procumbens</i> against Hyperglycemia and Hyperlipidemia Induced in Wistar Rats

2021 ◽  
Vol 12 (07) ◽  
pp. 127-140
Author(s):  
Jean-Baptiste Amagbegnon ◽  
Omédine Koukoui ◽  
Pascal C. Agbangnan ◽  
Santorin Seton ◽  
Mansouratou Betira ◽  
...  
2021 ◽  
Vol 274 ◽  
pp. 114004
Author(s):  
Jude C. Ikewuchi ◽  
Catherine C. Ikewuchi ◽  
Mercy O. Ifeanacho ◽  
Victoria S. Jaja ◽  
Esther C. Okezue ◽  
...  

2021 ◽  
Vol 11 ◽  
pp. e00636
Author(s):  
Mercy O. Ifeanacho ◽  
Jude C. Ikewuchi ◽  
Catherine C. Ikewuchi ◽  
Prince C. Nweke ◽  
Ruth Okere ◽  
...  

2015 ◽  
Vol 15 (2) ◽  
pp. 100-104
Author(s):  
G.O. Obochi ◽  
J. Ikwebe ◽  
S.A. Ogli ◽  
J.J. Oloche

2006 ◽  
Vol 49 (6) ◽  
pp. 927-934 ◽  
Author(s):  
Juliana Maganha ◽  
Evelise de Souza Rocha ◽  
Marcos Antônio Fernandes Brandão ◽  
Vera Maria Peters ◽  
Martha de Oliveira Guerra

Lapachol, a naphthoquinone extracted from plants of the genus Tabebuia (family Bignoneaceae), showed multiple therapeutic activities. Pregnant Wistar rats were treated with Lapachol from the 1st to the 4th (pre-implantation period) and from 5th to 7th (implantation period) post insemination day (PID). Mothers were sacrificed on the 5th or on the15th PID. Number of corpora lutea, preimplantation embryo, blastocysts, live and dead fetuses and resorptions were counted. There were no signs of maternal toxicity. The number and the morphology of embryos, during oviduct development (pre-implantation period), did not seem to be affected by this drug, but during the implantation period, lapachol was toxic causing the death of embryos and intrauterine growth retardation.


2020 ◽  
Vol 17 (1) ◽  
pp. 24-28
Author(s):  
Felix Oghenemaro Enwa ◽  
Johnson Daniel Jemikalajah ◽  
Michael Oghenejobo ◽  
Victor Eseoghene Oghenebrume

The aim of the study is to evaluate the effects of the methanolic extract of Tridax procumbens L. flower on the hematological and serum lipid profile of Albino Wistar rats. Ten male albino Wistar rats were obtained and divided into two groups (control and test). The flowers were extracted by cold maceration using methanol. The extract was then administered orally to the Test group at a dose of 100 mg/kg/d. Thereafter, blood samples were obtained from both groups and the hematological and serum lipid parameters were analyzed using auto-analyzers. The results of the hematological parameters obtained for Test group were; PCV-46.2%, Hemoglobin-14.656 g/dl, Platelets-141.08 mm3, Eosinophil-4.0%, Neutrophil-38%, Mean corpuscular hemoglobin (MCH)-35.532pg, Mean corpuscular hemoglobin concentration (MCHC)-32.11gl and Mean corpuscular volume (MCV)-108.658 ft, which were higher compared to the Control; while that of the serum lipid profiles were determined to be; Cholesterol-142.58 mg/dl,Triglycerides-157.58 mg/dl, HDL-56.72 mg/dl, LDL-55.944 mg/dl and VLDL-31.516 mg/dl. The plants were seen to have slight weight reducing activity, no significant effect on total white blood cell count, increased eosinophils, neutrophils, packed cell volume, platelet count, mean corpuscular  hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), HDL, and reduced LDL, VLDL,triglycerides, cholesterol on the rats tested. Hence, from this study, this plant can serve as a good candidate to be used as a hematinic agent, as  weight reducers, and a lipid lowering agent. Keywords: Tridax procumbens, Wistar rat, HDL, LDL MCV, MCHC


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