Antihypertensive Activity of Different Fractions of Tridax Procumbens Crude Aqueous Extract in Wistar Rats

Aim and Objectives: Demonstrating the exact quantity of Moringa oleifera (MO) that will cure any hepatocyte diseases and the one that can harm the hepatocytes of the Adult Wistar rats. Methods: Twenty (20) adult Wistar rats (both sex) were used for the study (caged based on same sex to avoid mating and pregnancy) and were randomly assigned into four groups (n=5); A-Control, B-250 mg/body weight (BW) of MO, C-500 mg/BW of MO, and D-750 mg/BW of MO orally. Result: The crude aqueous extract of MO Lam, shows insignificant increased in BW at the 1st week of administration which latter dropped little by little doing the weeks of the administration in groups (B, C, and D) rats, by comparing (p<0.05) to the control group after MO administration, the organ (Kidneys) shows a significant difference between the kidneys (left and right kidneys) in relation to the control group rats. MO increases the weight of the animals morphologically by comparing the weight of the animals before and after administration. Histological sections shows a normal Glomerulli, Peri-Glomerular Space, Convoluted Tubules, and Interstitium, after administration of the Crude Aqueous Extract of MO lame in terms with the control group rats. Conclusion: MO is a good herb that has no damage effect on the body and hepatocytes but of more beneficial.

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Some effects of simultaneous administration of crude aqueous extracts of Mangifera indica leaves and tetracyline on the liver of adults wistar rats

Anatomy Journal of Africa ◽

10.4314/aja.v6i2.160463 ◽

1970 ◽

Vol 6 (2) ◽

pp. 934-942

Author(s):

M.S. Peterson ◽

Adesina J. Ajibade ◽

Peter B. Olaitan

Keyword(s):

Adverse Effect ◽

Aqueous Extract ◽

Therapeutic Dose ◽

Wistar Rats ◽

Mangifera Indica ◽

Liver Histology ◽

Central Vein ◽

Hepatic Enzymes ◽

Mango Leaves ◽

Crude Aqueous Extract

This study was designed to determine the simultaneous effect of Mangifera indica crude aqueous extract and the therapeutic dose of tetracycline on some hepatic enzymes (ALT and AST) and histology of the liver of adult wistar rats. 25 wistar rats were divided into 5 groups: Group A was untreated and served as control group, group B was treated with only 2mL of mango leaves decoction, group C was treated with only 5.4mg/kg of tetracycline, group D was treated with 1mL of mango leaves decoction and 4.8mg/kg of tetracycline and group E was treated with 3mL of mango leaves decoction and 7.7mg/kg of tetracycline simultaneously. The administration period lasted for only 14 days which was given gavagely and the rats were sacrificed on the 15th day by cervical dislocation. The liver was removed, fixed in 10% formal saline and stained in H and E. The transaminase enzymes (the AST and ALT) were measured to determine possible changes in their hepatic leaves. The result shows that the crude aqueous extract of mango levels has adverse effect on the morphology and some hepatic enzyme (ALT and AST) of the liver (such as enlargement of the central vein, reduction in the size of sinusoids), the therapeutic dose of the tetracycline have no detrimental effect on the morphology and the hepatic enzymes of the liver. In conclusion, the extract of mango leaves decoction has adverse effect on the liver histology and the therapeutic dosage of tetracycline has no adverse effect on the histology of the liver.Keywords: Mango leaves, Tetracycline, Liver histology, Liver enzymes (AST and ALT)

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Histological Effects and Prenatal Exposure to Crude Aqueous Extract of Morinda lucida Leaves on the Frontal Cortex of Growing Wistar Rats

Journal of Advances in Medical and Pharmaceutical Sciences ◽

10.9734/jamps/2018/46182 ◽

2019 ◽

Vol 19 (3) ◽

pp. 1-8

Author(s):

O. O. Adeleye ◽

A. A. Akande ◽

A. A. Odetola

Keyword(s):

Frontal Cortex ◽

Prenatal Exposure ◽

Aqueous Extract ◽

Wistar Rats ◽

Crude Aqueous Extract

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Antihypertensive Effects of Gmelina Arborea Roxb (Verbenaceae) Leaves Crude Aqueous Extract Fractions in Wistar Rats

Journal of Physiology and Pharmacology Advances ◽

10.5455/jppa.20151216030740 ◽

2015 ◽

Vol 5 (12) ◽

pp. 803 ◽

Cited By ~ 1

Author(s):

Awede B ◽

Osseni R ◽

Lagnika L ◽

Adjagba M ◽

Kpadonou C ◽

...

Keyword(s):

Aqueous Extract ◽

Wistar Rats ◽

Gmelina Arborea ◽

Crude Aqueous Extract

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Biochemical and Haemopoietic Effects of Aqueous Extract of Gnetum Africanum (Ukazi) on Male and Female Albino Wistar Rats

Greener Journal of Medical Sciences ◽

10.15580/gjms.2018.4.080418111 ◽

2018 ◽

Vol 8 (4) ◽

pp. 061-065

Author(s):

F.N OGUWIKE ◽

◽

I.C IFEDI ◽

C.N DIM ◽

C.P IGWEDIBIA ◽

...

Keyword(s):

Aqueous Extract ◽

Wistar Rats ◽

Male And Female

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Ruta montana evokes antihypertensive activity through increase of prosta-glandins release in L-NAME-induced hypertensive rats

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530320666200628025430 ◽

2020 ◽

Vol 20 ◽

Author(s):

El-Ouady Fadwa ◽

Mohamed Eddouks

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Aqueous Extract ◽

Antihypertensive Effect ◽

Antihypertensive Activity ◽

Computer Assisted ◽

Hypertensive Rats ◽

Vasorelaxant Effect ◽

Vasorelaxant Activity ◽

Ruta Montana

Aims: The aim of the study was to investigate experimentally the antihypertensive effect of Ruta Montana. Background: Ruta montana L. is traditionally used in Moroccan herbal medicine to treat hypertension. This study aimed to evaluate experimentally the hypotensive and vasoactive properties of this plant. Objective: The objective of the study was to evaluate the effect of the aqueous extract of Ruta Montana on blood pressure parameters in LNAME-induced hypertensive rats and to determine the vasorelaxant activity of this aqueous extract. Methods: The antihypertensive effect of the aqueous extract obtained from Ruta montana aerial parts (RMAPAE) (200 mg/kg) was evaluated in normal and anesthetized hypertensive rats. Blood pressure parameters (systolic blood pressure (SBP), mean blood pressure (MBP) and diastolic blood pressure (DBP)) and heart rate were measured using a tail-cuff and a computer-assisted monitoring device. The acute and chronic effect of RMAPAE was recorded during 6 hours for the acute experiment and during 7 days for the sub-chronic test. In the other set, the vasorelaxant effect of RMAPAE on the contractile response was undertaken in isolated thoracic aorta. Results: The results indicated that RMAPAE extract significantly decreased SBP, MBP, DBP and heart rate in L-NAMEinduced hypertensive rats. Furthermore, RMAPAE was demonstrated to induce a dose dependent relaxation in the aorta precontracted with Epinephrine or KCl. More interestingly, this vasorelaxant activity of RMAPAE seems to be probably mediated through the prostaglandins pathway. Conclusion: The present study illustrates the beneficial action of Ruta montana on hypertension and supports then its use as an antihypertensive agent.

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Antioxidant Evaluation of the Aqueous Extract of Hulls of Campsiandra laurifolia in Colitis Induced by Acetic Acid in Wistar Rats

Journal of Coloproctology ◽

10.1055/s-0041-1730258 ◽

2021 ◽

Vol 41 (02) ◽

pp. 138-144

Author(s):

Lucas Petitemberte de Souza ◽

Henrique Sarubbi Fillmann ◽

Sandielly Rebeca Benitez da Fonseca ◽

Marilda da Silva Brasil ◽

Norma Anair Possa Marroni ◽

...

Keyword(s):

Acetic Acid ◽

Phenolic Compounds ◽

Aqueous Extract ◽

Wistar Rats ◽

Antioxidant Activities ◽

Experimental Colitis ◽

Anal Pressure ◽

Antioxidant Power ◽

Significance Level ◽

Sphincter Anal

AbstractDue to the ethnopharmacological use of Campsiandra laurifolia (Fabaceae), popularly known as Acapurana, to treat wounds and ulcers, associated with the lack of alternative treatments for intestinal inflammations such as ulcerative colitis (UC), the present work sought to characterize its phytochemical and antioxidant activities, and to evaluate remedial action in experimental colitis with acetic acid. Phytochemical analyzes were performed through qualitative and quantitative colorimetric tests of the main secondary metabolites. In the colitis model, 24 male Wistar rats aged ± 60 days old were used, divided into 4 groups: Control (CO) control + aqueous extract of C. laurifolia 50 mg/kg (CO + A50); Colitis (CL); and Colitis + aqueous extract of C. laurifolia 50 mg/kg (CL + A50). Measurement of sphincter anal pressure and histological tests of the large intestine, lipoperoxidation (LPO), enzyme activity of superoxide dismutase (SOD), and levels of glutathione (GSH) were performed. For statistical analysis, the oxidative stress (OS) results were expressed as means ± standard error, adopting a significance level of p < 0.05. The screening indicated the presence of flavonoids, saponins and tannins in the extract, with high levels of phenolic compounds and tannins, and was related to high antioxidant capacity. In the histological analysis, the CL group presented loss of the crypts, edema and inflammatory infiltrate. The use of C. laurifolia extract restructured the crypts, decreased edema and increased sphincter anal pressure, with a decrease in LPO, SOD, and an increase in GSH. It is suggested that the use of C. laurifolia extract reduces OS due to its antioxidant power conferred by the phenolic compounds present in the extract.

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