The Relationships between Body Mass Index and Left Ventricular Diastolic Function in a Structurally Normal Heart with Normal Ejection Fraction

Background Diastolic dysfunction is a common cause of heart failure with preserved systolic function in obese patients. Objective To assess diastolic function in a series of overweight and obese patients using conventional and tissue Doppler echocardiography. Setting and Method University hospital; left ventricular diastolic function was evaluated in 99 patients (mean age 61.59 ± 13.9 years); body mass index and waist circumference were assessed, and patients were subdivided into three groups according to their body mass index (kg/m2): [normal, (18.5-24.9); overweight, (25-29.9); obese, (> 29.9)]. Peak early (E) and late (A) transmural flow and peak early (E′) diastolic mitral annulus velocities were measured. Results Diastolic dysfunction was significantly higher in the overweight/obese groups compared to the normal body mass index group. The analysis was made with regard to waist circumference and other clinical characteristics, and multivariate regression analysis showed a direct and independent effect of body mass index on diastolic function [OR: 2.75; CI: 1.34-5.67; P = 0.006]. Discussion was made in view of the latest clinical data. Also, an insight into normal weight obesity is presented and discussed. Conclusion Overweight and obesity are found to have an independent negative impact on diastolic function as assessed by tissue Doppler imaging.

Download Full-text

Are there gender differences in the association between body mass index and left ventricular diastolic function? A clinical observational study in the Japanese general population

Echocardiography ◽

10.1111/echo.14866 ◽

2020 ◽

Vol 37 (11) ◽

pp. 1749-1756

Author(s):

Megumi Hirokawa ◽

Masao Daimon ◽

Kayoko Kozuma ◽

Tomohiro Shinozaki ◽

Koichi Kimura ◽

...

Keyword(s):

Body Mass Index ◽

Gender Differences ◽

General Population ◽

Observational Study ◽

Diastolic Function ◽

Body Mass ◽

Left Ventricular Diastolic Function ◽

Left Ventricular ◽

Ventricular Diastolic Function ◽

Japanese General Population

Download Full-text

Risk factors for longitudinal changes in left ventricular diastolic function among women and men

Heart ◽

10.1136/heartjnl-2018-314487 ◽

2019 ◽

Vol 105 (18) ◽

pp. 1414-1422 ◽

Cited By ~ 3

Author(s):

Oscar L Rueda-Ochoa ◽

Marco A Smiderle-Gelain ◽

Dimitris Rizopoulos ◽

Klodian Dhana ◽

Jan-Kees van den Berge ◽

...

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Diastolic Function ◽

Body Mass ◽

Left Ventricular Diastolic Function ◽

Left Ventricular ◽

Community Dwelling ◽

Mixed Effect ◽

Ventricular Diastolic Function ◽

Longitudinal Changes

ObjectiveTo evaluate changes in left ventricular diastolic function (LVDF) parameters and their associated risk factors over a period of 11 years among community-dwelling women and men.MethodsEchocardiography was performed three times among 870 women and 630 men (age 67±3 years) from the prospective population-based Rotterdam Study during a period of 11-year follow-up. Changes in six continuous LVDF parameters were correlated with cardiovascular risk factors using a linear-mixed effect model (LMM).ResultsIn women, smoking was associated with deleterious longitudinal changes in deceleration time (DT) (Beta (β): 7.73; 95% CI 2.56 to 12.9) and high-density lipoprotein cholesterol was associated with improvement of septal e′ (β: 0.37; 95% CI 0.13 to 0.62) and E/e′ ratio (β: −0.46; 95% CI −0.84 to –0.08) trajectories. Among men, diabetes was associated with deleterious longitudinal changes in A wave (β: 3.83; 95% CI 0.06 to 7.60), septal e′ (β: −0.40; 95% CI −0.70 to –0.09) and E/e′ ratio (β: 0.60; 95% CI 0.14 to 1.06) and body mass index was associated with deleterious longitudinal changes in A wave (β: 1.25; 95% CI 0.84 to 1.66), E/A ratio (β: −0.007; 95% CI −0.01 to –0.003), DT (β: 0.86; 95% CI 0.017 to 1.71) and E/e′ ratio (β: 0.12; 95% CI 0.06 to 0.19).ConclusionsSmoking among women and metabolic factors (diabetes mellitus and body mass index) among men showed larger deleterious associations with longitudinal changes in LVDF parameters. The favourable association of HDL was mainly observed among women. This study, for the first time, evaluates risk factors associated with changes over time in continuous LVDF parameters among women and men and generates new hypothesis for further medical research.

Download Full-text