Progress in study of spectrum-effect relationship of traditional Chinese medicine and discussions

2015 ◽  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Effect Relationship ◽  
Relationship Of ◽  
Spectrum Effect

Clinical Strategy for Optimal Traditional Chinese Medicine (TCM) Herbal Dose Selection in Disease Therapeutics: Expert Consensus on Classic TCM Herbal Formula Dose Conversion

2015 ◽  
Vol 43 (08) ◽  
pp. 1515-1524 ◽  
Author(s):  
Lin-Hua Zha ◽  
Li-Sha He ◽  
Feng-Mei Lian ◽  
Zhong Zhen ◽  
Hang-Yu Ji ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Measurement System ◽  
Expert Consensus ◽  
Dose Effect ◽  
Herbal Formula ◽  
Dose Selection ◽  
Effect Relationship ◽  
Weight Measurement ◽  
Relationship Of

The clinical therapeutics of traditional Chinese medicine (TCM) constitutes a complicated process which involves theory, diagnosis, and formula prescription with specific herbal dosage. Zhang Zhong-Jing’s classic work, Treatise on Febrile and Miscellaneous Diseases, has been influencing TCM practice for almost 2000 years. However, during this extended period of time in Chinese history, the Chinese weight measurement system experienced noticeable changes. This change in the weight measurement system inevitably, and perhaps even negatively, affected TCM herbal dosage determination and treatment outcome. Thus, in modern society, a full understanding of the accuracy of herbal dose selection has a critical importance in the TCM daily practice of delivering the best treatment to the patients suffering from different illnesses. In the 973 Project of the Chinese National Basic Research Program, expert consensus on classic TCM formula dose conversion has been reached based on extensive literature review and discussion on the dose–effect relationship of classic TCM formulas. One “liang” (两) in classic TCM formulas is equivalent to 13.8[Formula: see text]g. However, based on many TCM basic and clinical studies of variable herbal formula prescriptions and herbal drug preparations, the rule of one liang equals 13.8[Formula: see text]g should be adjusted according to different disease conditions. Recommended by the committee on TCM formula dose–effect relationship of the China Association of Chinese Medicine and the World Federation of Chinese Medicine Societies, the following expert consensus has been reached: (i) One liang converts to 6–9[Formula: see text]g for the severely and critically ill patients. (ii) One liang converts to 3–6[Formula: see text]g for the patients suffering from chronic diseases. (iii) One liang converts to 1–3[Formula: see text]g in preventive medicine. The above conversions should be used as a future TCM practice guideline. Using this recommended guideline should enhance the effectiveness of daily TCM practice.

scholarly journals Study on the Dose-effect Relationship of Moxa Burning Fumigation in Air Disinfection in Traditional Chinese Medicine Clinics

2020 ◽  
Vol 1 (3) ◽  
Author(s):  
Shunhua Teng ◽  
Guoyong Ma ◽  
Guozhong Lyu
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Indoor Air ◽  
Dose Effect ◽  
Effect Relationship ◽  
Significant Difference ◽  
Moxa Stick ◽  
Bacterial Content ◽  
Air Disinfection ◽  
Relationship Of

Objective — It’s to study the dose-effect relationship of moxa produced by Gansu Baicao Group in the air disinfection in traditional Chinese medicine clinics. Method — Use moxa sticks burning fumigation to disinfect indoor air in the clinics of traditional Chinese medicine experts; use the natural sedimentation method to detect the bacterial content in the air; compare the sterilization effects of 0.5, 1 and 1.5 moxa sticks 0 h, 1 h and 2 h after air disinfection. Results — In the 54m3 TCM clinic, there was no significant difference in the sterilization rate of air bacteria 0h, 1h, and 2h after using 1 moxa stick and 1.5 moxa sticks respectively for fumigation and disinfection (P>0.05). There was a significant difference in the sterilization rate of air bacteria between 1 moxa stick group and 0.5 moxa stick group 0 h after air disinfection (P < 0. 05). There was a significant difference in the sterilization rate of air bacteria between 0 hour and 1 hour after burning fumigation for air disinfection in 0.5 moxa group (P < 0. 05). Conclusion — The best dose of moxa burning fumigation for air disinfection in 54m3 Chinese medicine clinic is 0.5 stick; the best time for air disinfection is 1h after disinfection.

The Approach for Dose-Effect Relationship of TCM Research Based the Overall Effect of Metabonomics

2014 ◽  
Vol 590 ◽  
pp. 833-836
Author(s):  
Qi Yun Zhang ◽  
Jia Li ◽  
Bing Tao Li ◽  
Jian Jiang Fu ◽  
Ri Yue Yu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Water Extract ◽  
Dose Effect ◽  
Time Saving ◽  
Effect Relationship ◽  
Bioinformatics Software ◽  
Relationship Of ◽  
Tof Ms

In this paper, PCA combined with Mass Profiler Professional (MPP) bioinformatics software were used to build the dose-effect relationship of traditional Chinese medicine which based on the overall effect of metabonomics. The dataset from Da Cheng Qi Decoction (DCQD) water extract administrated rats plasma collected by UHPLC-Q-TOF-MS and used to demonstrate this method. The approach was confirmed to be an effective and time-saving tool for describing the dose-effect relationship of traditional Chinese medicine.

scholarly journals Study on the Spectrum-Effect Relationship of the Traditional Effect of Saponins in Glycyrrhiza uralensis Fisch

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Wenxin Xia ◽  
Qiansong Liu ◽  
Hao Zhou ◽  
Shiyao Hua ◽  
Lin Dong ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
High Performance ◽  
Gray Relational Analysis ◽  
Least Squares Regression ◽  
Effect Relationship ◽  
Long Time ◽  
Pharmacological Substance ◽  
New Research ◽  
Spectrum Effect

Licorice is a traditional Chinese medicine that has been used for a long time in China and still in great use today. The effect of licorice on tonifying spleen and invigorating qi has been proved for thousands of years, but the material basis of its effect is not clear. In this paper, we established the fingerprints of 21 batches of licorice collected from different origins in China with High-Performance Liquid Chromatography (HPLC) to identify the common peaks. Its effect of tonifying spleen and invigorating qi was confirmed through a series of praxiology experiments. The spectrum-effect relationship between HPLC fingerprints and its effect of tonifying spleen and invigorating qi of licorice was examined by gray relational analysis and partial least squares regression analysis. Results showed that the effect of licorice on tonifying spleen and invigorating qi resulted from various compounds and peaks. X2–X6 is presumed to be the main pharmacological substance base. This research successfully identified the spectrum-effect relationship between HPLC fingerprints and the effect of licorice on tonifying spleen and invigorating qi. The research method based on the spectrum-effect relationship helps provide new research ideas and strategies for the study of the basis of the medicinal materials and quality control of traditional Chinese medicine.

The impact of Traditional Chinese Medicine on mitophagy in disease models

2021 ◽  
Vol 27 ◽  
Author(s):  
Li-Ping Yu ◽  
Ting-Ting Shi ◽  
Yan-Qin Li ◽  
Jian-Kang Mu ◽  
Ya-Qin Yang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Molecular Mechanisms ◽  
Human Diseases ◽  
Regulatory Mechanisms ◽  
Disease Models ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship

: Mitophagy plays an important role in maintaining mitochondrial quality and cell homeostasis through the degradation of damaged, aged, and dysfunctional mitochondria and misfolded proteins. Many human diseases, particularly neurodegenerative diseases, are related to disorders of mitochondrial phagocytosis. Exploring the regulatory mechanisms of mitophagy is of great significance for revealing the molecular mechanisms underlying the related diseases. Herein, we summarize the major mechanisms of mitophagy, the relationship of mitophagy with human diseases, and the role of traditional Chinese medicine (TCM) in mitophagy. These discussions enhance our knowledge of mitophagy and its potential therapeutic targets using TCM.

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