The European Union is an important player in the U.S. policies aimed at maintaining liberal world order. The US-EU interaction has been shaped by a number of key variables, including international environment, specific goals of the U.S. administrations, institutional maturing of the EU, and a complex interplay of American and European diverging and overlapping interests. President D. Trump’s tenure was the most strained period in the US-EU relations, with an erosion of mutual trust and a ghost of trade war looming large. The Biden administration has reversed the U.S. policy towards the European Union. The US-EU summit held last June signified a return of normality in the relations of the transatlantic partners. Washington and Brussels outlined a broad agenda that embraces security, trade and economic issues, coordination in international affairs (concerning, in particular, Russia, China, and Iran), cooperation in decarbonizing of the world economy and promotion of a climate-friendly environment. A broad web of links between the United States and Europe facilitates their joining efforts in addressing global and regional challenges. Although, the US and the EU reached a series of compromises to mitigate their most acrimonious disagreements (Boeing–Airbus subsidies dispute is a vivid example in this regard), there are still unsettled major issues like a comprehensive free trade treaty unsuccessfully negotiated since the Obama presidency. The “Chinese factor” may turn out to be the most divisive one in the transatlantic relations, since the U.S. tough policy towards Beijing makes the EU countries to take hard decisions they prefer to avoid. While it is premature to predict precise implications of the Biden administration’s policy, one can reasonably expect the EU to become a more helpful partner to Washington in diplomatic and economic affairs.