scholarly journals Experimental study on the inhibitory effect of sodium cantharidinate on human hepatoma HepG2 cells

2013 ◽  
Vol 11 (1) ◽  
Author(s):  
SQ Wen ◽  
Q Chen ◽  
M Hu
Keyword(s):  
Experimental Study ◽  
Hepg2 Cells ◽  
Inhibitory Effect ◽  
Human Hepatoma ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

scholarly journals The Inhibitory Effect of 3β-Hydroxy-12-oleanen-27-oic Acid on Growth and Motility of Human Hepatoma HepG2 Cells through JNK and Akt Signaling Pathway

2013 ◽  
Vol 2013 ◽  
pp. 1-17 ◽  
Author(s):  
Juanjuan Wang ◽  
Xiangfeng Chen ◽  
Zhihua Zhou ◽  
Jinhui Li ◽  
Hongxiang Sun
Keyword(s):  
Hepg2 Cells ◽  
Molecular Mechanisms ◽  
Inhibitory Effect ◽  
Pcr Array ◽  
Human Hepatoma ◽  
Antitumor Effects ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

3β-Hydroxy-12-oleanen-27-oic acid (ATA) was a main antitumor active triterpene from the rhizomes ofAstilbe chinensis. In this study, we investigated its effects on growth, apoptosis, cell cycle, motility/invasion, and metatasis in human hepatoma HepG2 cellsin vitroand antimetastasis of B16-F10 melanoma in micein vivo, as well as its molecular mechanisms of action using a high-throughput Cancer Pathway Finder PCR Array. ATA could not only induce tumor cells into apoptosis through the activation of both extrinsic and intrinsic pathways, arrest HepG2 cells in G2/M phase, but also suppress the invasion and metastasis abilities of HepG2 cells and the lung metastasis of B16-F10 melanoma in mice. PCR array assay revealed that ATA upregulated 9 genes including CDKN1A, MDM2, CFLAR (CASPER), TNFRSF10B (DR5), c-Jun, IL-8, THBS1, SERPINB5 (maspin), and TNF and downregulated 8 genes such as CCNE1, AKT, ANGPT1, TEK, TGFBR1, MMP9, U-PA, and S100A4. These results indicate that ATA could exert antitumor effects through activating JNK/MAPK and suppressing AKT signal transduction pathways and that ATA might be a potent anticancer agent.

Receptor binding and tyrosine kinase activation by insulin analogues with extreme affinities studied in human hepatoma HepG2 cells

Diabetes ◽  
1991 ◽  
Vol 40 (11) ◽  
pp. 1488-1495 ◽  
Author(s):  
K. Drejer ◽  
V. Kruse ◽  
U. D. Larsen ◽  
P. Hougaard ◽  
S. Bjorn ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Binding ◽  
Hepg2 Cells ◽  
Insulin Analogues ◽  
Human Hepatoma ◽  
Kinase Activation ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

Interaction of PIG11 and Hsp60 is Involved in Apoptosis in Human Hepatoma HepG2 Cells*

2010 ◽  
Vol 37 (10) ◽  
pp. 1138-1143
Author(s):  
Xiao-Min LIU ◽  
Rong HU ◽  
Xiao-Qiu LIANG ◽  
Xiao-Juan WANG ◽  
Yan WU ◽  
...  
Keyword(s):  
Hepg2 Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

scholarly journals GEP100/Arf6 Is Required for Epidermal Growth Factor-Induced ERK/Rac1 Signaling and Cell Migration in Human Hepatoma HepG2 Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e38777 ◽  
Author(s):  
ZhenZhen Hu ◽  
Jun Du ◽  
Ling Yang ◽  
YiChao Zhu ◽  
Yu Yang ◽  
...  
Keyword(s):  
Cell Migration ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Hepg2 Cells ◽  
Human Hepatoma ◽  
Epidermal Growth ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

scholarly journals Gambogic acid suppresses cytochrome P450 3A4 by downregulating pregnane X receptor and up-regulating DEC1 in human hepatoma HepG2 cells

2015 ◽  
Vol 4 (4) ◽  
pp. 1059-1071 ◽  
Author(s):  
Wei Liu ◽  
Rui Ning ◽  
Rui-Ni Chen ◽  
Jin-Hua Hu ◽  
Hai-Yan Gui ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Hepg2 Cells ◽  
Pregnane X Receptor ◽  
Gambogic Acid ◽  
Cytochrome P450 3A4 ◽  
Human Hepatoma ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

Gambogic acid suppresses cytochrome P450 3A4 by downregulating pregnane X receptor and up-regulating DEC1 in human hepatoma HepG2 cells.

Cytotoxic and genotoxic potential of Cr(VI), Cr(III)-nitrate and Cr(III)-EDTA complex in human hepatoma (HepG2) cells

Chemosphere ◽  
2016 ◽  
Vol 154 ◽  
pp. 124-131 ◽  
Author(s):  
Breda Novotnik ◽  
Janez Ščančar ◽  
Radmila Milačič ◽  
Metka Filipič ◽  
Bojana Žegura
Keyword(s):  
Hepg2 Cells ◽  
Human Hepatoma ◽  
Edta Complex ◽  
Genotoxic Potential ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

Modulation of NAD(P)H:quinone oxidoreductase by vanadium in human hepatoma HepG2 cells

2010 ◽  
Vol 24 (6) ◽  
pp. 1554-1561 ◽  
Author(s):  
Ghada Abdelhamid ◽  
Anwar Anwar-Mohamed ◽  
Mohey M. Elmazar ◽  
Ayman O.S. El-Kadi
Keyword(s):  
Hepg2 Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2
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