scholarly journals Phytochemical composition and antitrypanosomal activity of the leaf extract of Leptadenia hastata (Pers) Decne

2018 ◽  
Vol 10 (2) ◽  
pp. 292
Author(s):  
A Haruna ◽  
A Mann ◽  
E.O. Ogbadoyi
Keyword(s):  
Leaf Extract ◽  
Phytochemical Composition ◽  
Antitrypanosomal Activity

scholarly journals Metabolite profile of Nectandra oppositifolia Nees & Mart. and assessment of antitrypanosomal activity of bioactive compounds through efficiency analyses

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247334
Author(s):  
Geanne A. Alves Conserva ◽  
Luis M. Quirós-Guerrero ◽  
Thais A. Costa-Silva ◽  
Laurence Marcourt ◽  
Erika G. Pinto ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Natural Compound ◽  
Protocatechuic Acid ◽  
Metabolite Profile ◽  
Efficiency Analysis ◽  
Positive Control ◽  
Preparative Hplc ◽  
Phytochemical Composition ◽  
Antitrypanosomal Activity ◽  
Molecular Complexity

EtOH extracts from the leaves and twigs of Nectandra oppositifolia Nees & Mart. shown activity against amastigote forms of Trypanosoma cruzi. These extracts were subjected to successive liquid-liquid partitioning to afford bioactive CH2Cl2 fractions. UHPLC-TOF-HRMS/MS and molecular networking were used to obtain an overview of the phytochemical composition of these active fractions. Aiming to isolate the active compounds, both CH2Cl2 fractions were subjected to fractionation using medium pressure chromatography combined with semi-preparative HPLC-UV. Using this approach, twelve compounds (1–12) were isolated and identified by NMR and HRMS analysis. Several isolated compounds displayed activity against the amastigote forms of T. cruzi, especially ethyl protocatechuate (7) with EC50 value of 18.1 μM, similar to positive control benznidazole (18.7 μM). Considering the potential of compound 7, protocatechuic acid and its respective methyl (7a), n-propyl (7b), n-butyl (7c), n-pentyl (7d), and n-hexyl (7e) esters were tested. Regarding antitrypanosomal activity, protocatechuic acid and compound 7a were inactive, while 7b-7e exhibited EC50 values from 20.4 to 11.7 μM, without cytotoxicity to mammalian cells. These results suggest that lipophilicity and molecular complexity play an important role in the activity while efficiency analysis indicates that the natural compound 7 is a promising prototype for further modifications to obtain compounds effective against the intracellular forms of T. cruzi.

Phytochemical Composition and Antimalarial Activity of Methanol Leaf Extract of Crateva adansonii in Plasmodium berghei Infected Mice

2015 ◽  
Vol 6 (4) ◽  
pp. 165-173 ◽  
Author(s):  
A. Tsado ◽  
L. Bashir ◽  
S. Mohammed ◽  
I. Famous ◽  
A. Yahaya ◽  
...  
Keyword(s):  
Plasmodium Berghei ◽  
Leaf Extract ◽  
Antimalarial Activity ◽  
Phytochemical Composition

Phytochemical Composition and In vivo Antibacterial Activity of the Aqueous Leaf Extract of Polygonum limbatum on Escherichia coli-infected Guinea Pigs

2016 ◽  
Vol 8 (2) ◽  
pp. 1-12
Author(s):  
Joseph Kouamou ◽  
Siméon Fodouop ◽  
Guelmbaye Ndoutamia ◽  
Julius Ndukum ◽  
Joseph Tchoumboue ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibacterial Activity ◽  
Guinea Pigs ◽  
Leaf Extract ◽  
Phytochemical Composition ◽  
Aqueous Leaf Extract

scholarly journals Senna occidentalis leaf extract possesses antitrypanosomal activity and ameliorates the trypanosome-induced anemia and organ damage

2010 ◽  
Vol 2 (3) ◽  
pp. 175 ◽  
Author(s):  
MA Ibrahim ◽  
AB Aliyu ◽  
AB Sallau ◽  
M Bashir ◽  
I Yunusa ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Organ Damage ◽  
Antitrypanosomal Activity

Phytochemical Composition and Antioxidant Activity ofFicus benghalensis(Moraceae) Leaf Extract

2014 ◽  
Vol 4 (3) ◽  
pp. 236-248 ◽  
Author(s):  
K.V. Bhaskara Rao ◽  
V. Ojha ◽  
Preeti ◽  
G. Kumar ◽  
L Karthik
Keyword(s):  
Antioxidant Activity ◽  
Leaf Extract ◽  
Phytochemical Composition
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