Toxity of Gedunin, Piperine and Crude Extracts of their Natural Products on Growth and Development of Ostrinia Nubilalis Hbner (Lepidoptera: Pyrarlidae).

2000 ◽  
Vol 12 (1) ◽  
Author(s):  
F K Ewete ◽  
J T Arnason ◽  
T Durst ◽  
S Mackinnon
Keyword(s):  
Natural Products ◽  
Ostrinia Nubilalis ◽  
Growth And Development ◽  
Crude Extracts

Limonoids from the Meliaceae and Rutaceae reduce feeding, growth and development of Ostrinia nubilalis

1987 ◽  
Vol 43 (3) ◽  
pp. 221-226 ◽  
Author(s):  
J. T. Arnason ◽  
B. J. R. Philogène ◽  
N. Donskov ◽  
I. Kubo
Keyword(s):  
Ostrinia Nubilalis ◽  
Growth And Development

Discovering New Natural Products Directly from Crude Extracts by HPLC-SPE-NMR:  Chinane Diterpenes inHarpagophytumprocumbens

2006 ◽  
Vol 69 (4) ◽  
pp. 527-530 ◽  
Author(s):  
Cailean Clarkson ◽  
Steen Honoré Hansen ◽  
Peter J. Smith ◽  
Jerzy W. Jaroszewski
Keyword(s):  
Natural Products ◽  
Crude Extracts

scholarly journals In Vitro Antiviral Activity Against Zika Virus From a Natural Product of the Brazilian Brown Seaweed Dictyota menstrualis

2019 ◽  
Vol 14 (7) ◽  
pp. 1934578X1985912 ◽  
Author(s):  
Claudio C. Cirne-Santos ◽  
Caroline de S. Barros ◽  
Max W. L. Gomes ◽  
Rafaela Gomes ◽  
Diana N. Cavalcanti ◽  
...  
Keyword(s):  
Natural Products ◽  
Zika Virus ◽  
Brown Seaweed ◽  
Health Concern ◽  
Dependent Manner ◽  
Dictyota Menstrualis ◽  
Crude Extracts ◽  
High Concentrations ◽  
Inhibitory Potential

Natural products isolated from seaweeds have shown great antiviral potential against numerous viruses such as human type 1 herpes, human immunodeficiency virus, and dengue. Diterpenes produced by the brown seaweeds Dictyota and Canistrocarpus, in particular, have shown antiviral or virucidal activity. Recently, the Zika virus (ZIKV) has become a major public health concern due to its widespread dissemination throughout the Americas. Since no vaccines are available, and no drugs have effectively treated recent cases of infection, our group evaluated products from Dictyota menstrualis for their antiviral potential, alone and in combination with Ribavirin. We first evaluated the compounds’ cytotoxicity at high concentrations, and then evaluated the inhibition of ZIKV replication by crude extracts and acetylated crude extracts and their fractions at 20 μg/mL. The F-6 and FAc-2 fractions, rich in cyclic diterpenes with aldehyde groupings, inhibited ZIKV replication by >74%, with inhibition behaving in a dose-dependent manner and the 50% effective concentration (EC50) values of 2.80 (F-6) and 0.81 (FAc-2) μg/mL. Regarding the mechanism of action, FAc-2 had strong virucidal potential, and F-6 inhibited viral adsorption. Associating FAc-2 with Ribavirin at suboptimal dosages produced a strong synergistic effect that completely inhibited viral replication. Our results indicate that these natural products have excellent inhibitory potential against ZIKV replication and may be promising for developing affective therapies.

scholarly journals Solid-phase enrichment and analysis of electrophilic natural products

2017 ◽  
Vol 13 ◽  
pp. 405-409 ◽  
Author(s):  
Frank Wesche ◽  
Yue He ◽  
Helge B Bode
Keyword(s):  
Natural Products ◽  
Solid Phase ◽  
New Drugs ◽  
Crude Extracts ◽  
Novel Methods

In search for new natural products, which may lead to the development of new drugs for all kind of applications, novel methods are needed. Here we describe the identification of electrophilic natural products in crude extracts via their reactivity against azide as a nucleophile followed by their subsequent enrichment using a cleavable azide-reactive resin (CARR). Using this approach, natural products carrying epoxides and α,β-unsaturated enones as well as several unknown compounds were identified in crude extracts from entomopathogenic Photorhabdus bacteria.

A REVIEW ON NATURAL ANTI BIOFILM AGENTS FOR WOUND BIOFILM

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (10) ◽  
pp. 7-18
Author(s):  
Mahipriyaa S. R. ◽  
Baby Roselin R ◽  
Arjun K. ◽  
Nithyanth M. ◽  
Sankar V. ◽  
...  
Keyword(s):  
Natural Products ◽  
Growth And Development ◽  
Antibacterial Agents ◽  
Extracellular Polymeric Substances ◽  
Bacterial Resistance ◽  
Bacterial Biofilms ◽  
Wound Infections ◽  
Promising Candidate ◽  
Biofilm Growth ◽  
Micro Organisms

A biofilm may be a consortium of micro-organisms in which the cells of microbes attach to each other on a living or non-living surface inside a self-produced matrix of extracellular polymeric substances. The bacterial or fungal colonies invade the surface of the wounds, thereby delaying the healing cascade. The resistance is partially due to low metabolic rate of these colonies, which directly impacts the action of oral or parenteral antibiotics. Hence, there is an urgent need to develop antibacterial agents to regulate the biofilm growth and development. The last few decades have witnessed wide research studies attempting to investigate the anti-biofilm effects of natural products. This review will summarize the wound infections associated with biofilm, mechanisms of bacterial resistance due to biofilm and recent studies on discovery of natural products with their mechanisms for inhibiting various bacterial biofilms that can be a promising candidate which could provide novel strategies for biofilm-associated infections.

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