scholarly journals Synthesis and Characterization of Starch-Graft-Acrylamide Hydrogel for Oral Drug Delivery

2020 ◽  
Vol 27 (2) ◽  
pp. 16-21
Author(s):  
H. Musa ◽  
Y. Musa ◽  
M. Suleiman
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Drug Loading ◽  
Oral Drug ◽  
Intestinal Fluid ◽  
Simulated Intestinal Fluid ◽  
Swelling Capacity ◽  
Model Drug ◽  
Polymerization Method

In this research, starch was extracted from fresh sweet potato and was used to prepare starch-g-acrylamide hydrogel using free radical polymerization method with potassium per sulphate and N’N-Methylene bisacrylamide as initiator and cross-linker, respectively. The swelling capacity and pH sensitivity of the synthesized hydrogel were investigated in solutions of various pH (1-12). The drug loading and release experiment was also carried out using promethazine (PMZ) as the model drug at 25oC and 37oC, respectively while the release study was carried out in an enzyme-free simulated gastric intestinal fluid (SGF) and simulated intestinal fluid (SIF). The result showed a 905% swelling at pH 11, suggesting increased swelling capacity at higher pH values. Drug loading result indicated 99% of the drug was entrapped by the hydrogel as confirmed by UV-visible spectrophotometry. SIF and SGF Simulation indicated a 24% and 9% drug release for the first ten hours. At the end of 48 hours the release was 96% and 89%, respectively indicating the hydrogel released more promethazine in SIF than in SGF. The results obtained in this work suggest that starch-graft-acrylamide hydrogel is a potential vehicle for oral drug delivery. Keywords: Starch, Acrylamide, Hydrogel, Drug delivery.

Preparation and characterization of mucus-penetrating papain/poly(acrylic acid) nanoparticles for oral drug delivery applications

2012 ◽  
Vol 15 (1) ◽  
Author(s):  
Christiane Müller ◽  
Katharina Leithner ◽  
Sabine Hauptstein ◽  
Fabian Hintzen ◽  
Willi Salvenmoser ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Acrylic Acid ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Drug Delivery Applications ◽  
Poly Acrylic Acid

scholarly journals Rapid Synthesis of Superabsorbent Smart-Swelling Bacterial Cellulose/Acrylamide-Based Hydrogels for Drug Delivery

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Manisha Pandey ◽  
Mohd Cairul Iqbal Mohd Amin ◽  
Naveed Ahmad ◽  
Muhammad Mustafa Abeer
Keyword(s):  
Drug Delivery ◽  
Bacterial Cellulose ◽  
Oral Drug Delivery ◽  
Drug Loading ◽  
Solvent System ◽  
Physicochemical Characteristics ◽  
Oral Drug ◽  
X Ray Diffraction ◽  
Spectroscopy Analysis ◽  
Drug Release Profile

This study evaluated the effect of solubilized and dispersed bacterial cellulose (BC) on the physicochemical characteristics and drug release profile of hydrogels synthesized using biopolymers. Superabsorbent hydrogels were synthesized by graft polymerization of acrylamide on BC solubilized in an NaOH/urea solvent system and on dispersed BC by usingN,N′-methylenebisacrylamide as a crosslinker under microwave irradiation. Fourier transform infrared spectroscopy analysis of the resulting hydrogels confirmed the grafting, and an X-ray diffraction pattern showed a decrease in the crystallinity of BC after the grafting process. The hydrogels exhibited pH and ionic responsive swelling behavior, with hydrogels prepared using solubilized BC (SH) having higher swelling ratios. Furthermore, compared to the hydrogels synthesized using dispersed BC, the hydrogels synthesized using solubilized BC showed higher porosity, drug loading efficiency, and release. These results suggest the superiority of the hydrogels prepared using solubilized BC and that they should be explored further for oral drug delivery.

scholarly journals Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 777
Author(s):  
Maryam Farzan ◽  
Gabriela Québatte ◽  
Katrin Strittmatter ◽  
Florentine Marianne Hilty ◽  
Joachim Schoelkopf ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Large Scale ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Phospholipid Content ◽  
Liposomal Drug ◽  
Rate Of Dissolution ◽  
Porous Microparticles ◽  
Model Drug

Despite the wide-spread use of liposomal drug delivery systems, application of these systems for oral purposes is limited due to their large-scale formulation and storage issues. Proliposomes are one of the formulation approaches for achieving solid powders that readily form liposomes upon hydration. In this work, we investigated a dry powder formulation of a model low-soluble drug with phospholipids loaded in porous functionalized calcium carbonate microparticles. We characterized the liposome formation under conditions that mimic the different gastrointestinal stages and studied the factors that influence the dissolution rate of the model drug. The liposomes that formed upon direct contact with the simulated gastric environment had a capacity to directly encapsulate 25% of the drug in situ. The emerged liposomes allowed complete dissolution of the drug within 15 min. We identified a negative correlation between the phospholipid content and the rate of water uptake. This correlation corroborated the results obtained for the rate of dissolution and liposome encapsulation efficiency. This approach allows for the development of solid proliposomal dosage formulations, which can be scaled up with regular processes.

Development and characterization of anionic liposaccharides for enhanced oral drug delivery

2012 ◽  
Vol 430 (1-2) ◽  
pp. 120-128 ◽  
Author(s):  
Adel S. Abdelrahim ◽  
Pavla Simerska ◽  
Istvan Toth
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Oral Drug

Microencapsulation of nanoparticles with enhanced drug loading for pH-sensitive oral drug delivery for the treatment of colon cancer

2012 ◽  
Vol 129 (2) ◽  
pp. 714-720 ◽  
Author(s):  
Yichao Wang ◽  
Puwang Li ◽  
Zheng Peng ◽  
Feng Hua She ◽  
Ling Xue Kong
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Oral Drug Delivery ◽  
Drug Loading ◽  
Ph Sensitive ◽  
Oral Drug
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