scholarly journals Histologic and histomorphometric assessment of eggshell-derived bone graft substitutes on bone healing in rats

2013 ◽  
pp. e23-9 ◽  
Author(s):  
A. Uraz ◽  
SE. Gultekin ◽  
B. Senguven ◽  
B. Karaduman ◽  
IP. Sofuoglu ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Healing ◽  
Bone Graft Substitutes

Evaluation of bone healing with eggshell-derived bone graft substitutes in rat calvaria: A pilot study

2008 ◽  
Vol 87A (1) ◽  
pp. 203-214 ◽  
Author(s):  
Jin-Woo Park ◽  
Sang-Ryul Bae ◽  
Jo-Young Suh ◽  
Dong-Hee Lee ◽  
Sang-Hyun Kim ◽  
...  
Keyword(s):  
Pilot Study ◽  
Bone Graft ◽  
Bone Healing ◽  
Rat Calvaria ◽  
Bone Graft Substitutes

scholarly journals Bone healing of distal radius nonunion treated with bridge plating with bone graft substitutes in combination with systemic romosozumab administration: A case report

2021 ◽  
Vol 32 (2) ◽  
pp. 526-530
Author(s):  
Takuya Uemura ◽  
Koichi Yano ◽  
Kiyohito Takamatsu ◽  
Yusuke Miyashima ◽  
Hiroyuki Yasuda ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Bone Graft ◽  
Distal Radius ◽  
Bone Healing ◽  
Tricalcium Phosphate ◽  
Bone Union ◽  
Heavy Smoker ◽  
Bone Graft Substitutes ◽  
Bridge Plating

Romosozumab is a humanized, anti-sclerostin monoclonal antibody used to treat osteoporosis, which increases bone formation and decreases bone resorption. It enhances fracture healing and systemic romosozumab administration may have therapeutic potentials for accelerating bone healing of even nonunion. Herein, a 61-year-old heavy smoker male with distal radius nonunion who achieved successful bone union by combination therapy of romosozumab and spanning distraction plate fixation with bone graft substitutes was presented. Through the dorsal approach, atrophic comminuted nonunion of the distal radius was sufficiently debrided. Reduction of the distal radius was performed using indirect ligamentotaxis, and a 14-hole locking plate was fixed from the third metacarpal to the radial shaft. A beta (β) tricalcium phosphate block was mainly packed into the substantial metaphyseal bone defect with additional bone graft from the resected ulnar head. Postoperatively, systemic administration of monthly romosozumab was continued for six months. Complete bone union was achieved 20 weeks postoperatively and the plate was, then, removed. Wrist extension and flexion improved to 75o and 55o, respectively, without pain, and grip strength increased 52 weeks postoperatively from 5.5 kg to 22.4 kg. During romosozumab treatment, bone formation marker levels increased rapidly and finally returned to baseline, and bone resorption marker levels remained low. In conclusion, combination of systemic romosozumab administration and grafting β-tricalcium phosphate with bridge plating provides an effective treatment option for difficult cases of comminuted distal radius nonunion with risk factors such as smoking, diabetes, and fragility.

scholarly journals Synthetic bone graft versus autograft or allograft for spinal fusion: a systematic review

2016 ◽  
Vol 25 (4) ◽  
pp. 509-516 ◽  
Author(s):  
Zorica Buser ◽  
Darrel S. Brodke ◽  
Jim A. Youssef ◽  
Hans-Joerg Meisel ◽  
Sue Lynn Myhre ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Bone Graft ◽  
Spinal Fusion ◽  
Comparative Studies ◽  
Functional Outcomes ◽  
Retrospective Studies ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Bone Graft Substitutes

The purpose of this review was to compare the efficacy and safety of synthetic bone graft substitutes versus autograft or allograft for the treatment of lumbar and cervical spinal degenerative diseases. Multiple major medical reference databases were searched for studies that evaluated spinal fusion using synthetic bone graft substitutes (either alone or with an autograft or allograft) compared with autograft and allograft. Randomized controlled trials (RCT) and cohort studies with more than 10 patients were included. Radiographic fusion, patient-reported outcomes, and functional outcomes were the primary outcomes of interest. The search yielded 214 citations with 27 studies that met the inclusion criteria. For the patients with lumbar spinal degenerative disease, data from 19 comparative studies were included: 3 RCTs, 12 prospective, and 4 retrospective studies. Hydroxyapatite (HA), HA+collagen, β-tricalcium phosphate (β-TCP), calcium sulfate, or polymethylmethacrylate (PMMA) were used. Overall, there were no differences between the treatment groups in terms of fusion, functional outcomes, or complications, except in 1 study that found higher rates of HA graft absorption. For the patients with cervical degenerative conditions, data from 8 comparative studies were included: 4 RCTs and 4 cohort studies (1 prospective and 3 retrospective studies). Synthetic grafts included HA, β-TCP/HA, PMMA, and biocompatible osteoconductive polymer (BOP). The PMMA and BOP grafts led to lower fusion rates, and PMMA, HA, and BOP had greater risks of graft fragmentation, settling, and instrumentation problems compared with iliac crest bone graft. The overall quality of evidence evaluating the potential use and superiority of the synthetic biological materials for lumbar and cervical fusion in this systematic review was low or insufficient, largely due to the high potential for bias and small sample sizes. Thus, definitive conclusions or recommendations regarding the use of these synthetic materials should be made cautiously and within the context of the limitations of the evidence.

Influence of the proportion of particulate autogenous bone graft/platelet-rich plasma on bone healing in critical-size defects

Bone ◽  
2009 ◽  
Vol 45 (2) ◽  
pp. 339-345 ◽  
Author(s):  
Maria Nagata ◽  
Michel Messora ◽  
Roberta Okamoto ◽  
Natália Campos ◽  
Natália Pola ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Healing ◽  
Critical Size ◽  
Platelet Rich Plasma ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Critical Size Defects

A Novelty of Synthetic Hydroxyapatite from Cockle Shell and Characterization

2015 ◽  
Vol 1087 ◽  
pp. 429-433 ◽  
Author(s):  
Rusnah Mustaffa ◽  
Mohd Reusmaazran Mohd Yusof ◽  
Yusof Abdullah
Keyword(s):  
Bone Graft ◽  
Bone Repair ◽  
Artificial Bone ◽  
Synthetic Bone ◽  
Potential Source ◽  
Mineral Constituent ◽  
Bone Graft Substitutes ◽  
Synthetic Hydroxyapatite ◽  
Anadara Granosa ◽  
Cockle Shell

In Malaysia recently, it was found that cockle shell (Anadara granosa) is a potential source of biomaterial for bone repair. It is the most abundant sea species cultured in Malaysia. A possible advantage of using cockle shell as a biomaterial is that they may act as an antilog of calcium carbonate. Malaysian Nuclear Agency took this challenge to develop synthetic bone graft from natural cockle shell. To date, the artificial bone graft substitutes developed from hydroxyapatite (Ca10(PO4)6(OH)2) a bio ceramic is similar to the mineral constituent of human bone. The structure and the composition of hydroxyapatite (HA) are similar to the mineral phase of bone and, its bioactivity and biocompatibility makes it a preferred bone graft.

A Review of Bone Graft Substitutes Made From HA-Polymer Composite Scaffolds and Fabrication Potential With Laser-Based Additive Manufacturing Processes

2015 ◽  
Author(s):  
Hera Wu ◽  
Shuting Lei
Keyword(s):  
Additive Manufacturing ◽  
Bone Graft ◽  
Three Dimensional ◽  
Bone Graft Substitute ◽  
Biological Properties ◽  
Porous Scaffolds ◽  
Composite Scaffolds ◽  
Bone Graft Substitutes ◽  
Manufacturing Technologies ◽  
High Level

Hydroxyapatite, a bioactive ceramic, has been combined with biodegradable polymers to create composite three-dimensional interconnected porous scaffolds for bone graft substitutes. The materials and fabrication methods of these composite scaffolds are reviewed. The resulting mechanical and biological properties of scaffolds produced from the combination of certain materials and fabrication methods are analyzed. Requirements for a bone graft substitute and third generation scaffolds with the addition of osteoinductive and osteogenic features to composite scaffolds including biomolecule delivery and cell seeding are also introduced. Finally, the benefits of using additive manufacturing technologies to enable high level of control over the design of interconnected pore structure are discussed.

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