scholarly journals miR-1226 detection in GCF as potential biomarker of chronic periodontitis: A pilot study

2018 ◽  
pp. 0-0 ◽  
Author(s):  
P Mico-Martinez ◽  
J Garcia-Gimenez ◽  
M Seco-Cervera ◽  
A Lopez-Roldan ◽  
PJ Alminana-Pastor ◽  
...  
Keyword(s):  
Pilot Study ◽  
Chronic Periodontitis ◽  
Potential Biomarker

Anticipatory and Reactive Grip Force Control in Patients with Alzheimer’s Disease: A Pilot Study

2021 ◽  
pp. 1-15
Author(s):  
Anna Gabriel ◽  
Carolin T. Lehner ◽  
Chiara Höhler ◽  
Thomas Schneider ◽  
Tessa P.T. Pfeiffer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Pilot Study ◽  
Force Control ◽  
Grip Force ◽  
Object Manipulation ◽  
Step Test ◽  
Grip Force Control ◽  
Potential Biomarker ◽  
Neurological Conditions

Background: Alzheimer’s disease (AD) affects several cognitive functions and causes altered motor function. Fine motor deficits during object manipulation are evident in other neurological conditions, but have not been assessed in dementia patients yet. Objective: Investigate reactive and anticipatory grip force control in response to unexpected and expected load force perturbation in AD. Methods: Reactive and anticipatory grip force was investigated using a grip-device with force sensors. In this pilot study, fifteen AD patients and fourteen healthy controls performed a catching task. They held the device with one hand while a sandbag was dropped into an attached receptacle either by the experimenter or by the participant. Results: In contrast to studies of other neurological conditions, the majority of AD patients exerted lower static grip force levels than controls. Interestingly, patients who were slow in the Luria’s three-step test produced normal grip forces. The timing and magnitude of reactive grip force control were largely preserved in patients. In contrast, timing and extent of anticipatory grip forces were impaired in patients, although anticipatory control was generally preserved. These deficits were correlated with decreasing Mini-Mental State Examination scores. Apraxia scores, assessed by pantomime of tool-use, did not correlate with performance in the catching task. Conclusion: We interpreted the decreased grip force in AD in the context of loss of strength and lethargy, typical for patients with AD. The lower static grip force during object manipulation may emerge as a potential biomarker for early stages of AD, but more studies with larger sample sizes are necessary.

scholarly journals A Pilot Study - Comparison between a Novel Combination of Bioactive Glass with Clodronate and Bioactive Glass Alone as a Treatment for Chronic Periodontitis

2017 ◽  
Vol 07 (03) ◽  
Author(s):  
Kirsi Rosenqvist ◽  
Mervi Gursoy ◽  
Eija Kononen ◽  
Ulvi K Gursoy ◽  
Anne M Juppo
Keyword(s):  
Pilot Study ◽  
Bioactive Glass ◽  
Chronic Periodontitis

scholarly journals Cyclooxygenase 2 gene polymorphisms and chronic periodontitis in a North Indian population: a pilot study

2012 ◽  
Vol 42 (5) ◽  
pp. 151 ◽  
Author(s):  
Anika Daing ◽  
Sarvendra Vikram Singh ◽  
Charanjeet Singh Saimbi ◽  
Mohammad Akhlaq Khan ◽  
Srikanta Kumar Rath
Keyword(s):  
Pilot Study ◽  
Chronic Periodontitis ◽  
Gene Polymorphisms ◽  
Indian Population ◽  
Cyclooxygenase 2 ◽  
North Indian Population

Correlation of salivary neopterin and plasma fibrinogen levels in patients with chronic periodontitis and/or type 2 diabetes mellitus

Pteridines ◽  
2017 ◽  
Vol 28 (3-4) ◽  
pp. 177-183 ◽  
Author(s):  
Angel Fenol ◽  
V.R. Swetha ◽  
Sajitha Krishnan ◽  
Jayachandran Perayil ◽  
Rajesh Vyloppillil ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Periodontitis ◽  
Study Groups ◽  
Control Group ◽  
Diabetic Patients ◽  
Potential Biomarker ◽  
Whole Saliva ◽  
Nonsurgical Periodontal Therapy ◽  
Significant Difference

AbstractNeopterin is a novel predictor for coronary events especially in diabetic patients and also an indicator for the effectiveness of the periodontal treatment. In this study, we assessed whether salivary neopterin can be used as a potential biomarker in evaluating the risk of cardiovascular disease in type 2 diabetic patients with chronic periodontitis. Forty subjects between 25 and 75 years of age and who matched the criteria were selected and divided into four groups. Their periodontal status was evaluated. Stimulated whole saliva and blood were collected for analysis of salivary neopterin and fibrinogen and HbA1c levels, respectively. Nonsurgical periodontal therapy was carried out. Patients were recalled after 3 months, and the same procedure was repeated. A reduction in all the parameters was seen after treatment in all the four groups. Salivary neopterin levels showed significant difference (p<0.001) in the values between the study groups and the control group before treatment. After 3 months of treatment, salivary neopterin levels showed a statistical significant reduction (p<0.001) in all the study groups. Neopterin could serve as an effective tool to assess the inflammatory process related to periodontitis and diabetes mellitus and also predict future cardiovascular events in diabetic patients.

scholarly journals Pilot Study and Review: Physiological Differences in BDNF, a Potential Biomarker in Males and Females with Autistic Disorder

2015 ◽  
Vol 3 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Eve Spratt ◽  
Ann-Charlotte Granholm ◽  
Laura Carpenter ◽  
Heather Boger ◽  
Carrie Papa ◽  
...  
Keyword(s):  
Pilot Study ◽  
Autistic Disorder ◽  
Potential Biomarker ◽  
Males And Females ◽  
Physiological Differences

scholarly journals Expression of PCNA in oral gingival epithelium of aggressive and, chronic periodontitis—A pilot study

2013 ◽  
Vol 03 (01) ◽  
pp. 112-117 ◽  
Author(s):  
Penapy Jyostna ◽  
Manchala Sesha Reddy ◽  
Manyam Ravikanth ◽  
Mandalapu Narendra ◽  
Chini Dorasani Dwarakanath
Keyword(s):  
Pilot Study ◽  
Chronic Periodontitis ◽  
Gingival Epithelium ◽  
Oral Gingival Epithelium

scholarly journals Detection of Salivary miRNAs Reflecting Chronic Periodontitis: A Pilot Study

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1034 ◽  
Author(s):  
Kohei Fujimori ◽  
Toshiki Yoneda ◽  
Takaaki Tomofuji ◽  
Daisuke Ekuni ◽  
Tetsuji Azuma ◽  
...  
Keyword(s):  
Pilot Study ◽  
Chronic Periodontitis ◽  
Pocket Depth ◽  
Cross Sectional ◽  
Relative Expression ◽  
Reverse Transcription Pcr ◽  
Probing Pocket Depth ◽  
Severe Periodontitis ◽  
Whole Saliva ◽  
Unstimulated Whole Saliva

The purpose of this cross-sectional pilot study was to find salivary microRNAs (miRNAs) reflecting periodontal condition in chronic periodontitis. One hundred and twenty chronic periodontitis patients (mean age, 68.4 years) participated in the study, from whom unstimulated whole saliva was collected. A multiphase study was conducted to explore salivary miRNAs as biomarkers of periodontitis. At first, a polymerase chain reaction (PCR) array was performed to compare salivary miRNAs profiles in no and mild (no/mild) and severe periodontitis patients. Next, the relative expression of salivary miRNAs on individual samples was assessed by real-time reverse transcription-PCR. The numbers (%) of patients were 26 (21.6%, no/mild), 58 (48.3%, moderate) and 36 (30.0%, severe), respectively. Among 84 miRNAs, only the relative expression of hsa-miR-381-3p in the severe periodontitis group was significantly higher than that of the no/mild periodontitis group (p < 0.05). Among the 120 patients, there was also a significant correlation between the relative expression of hsa-miR-381-3p and the mean probing pocket depth (PPD) (r = 0.181, p < 0.05). Salivary hsa-miR-381-3p was correlated with periodontitis condition in chronic periodontitis patients.

Chronic periodontitis is associated with platelet factor 4 (PF4) secretion: A pilot study

2017 ◽  
Vol 44 (11) ◽  
pp. 1101-1111 ◽  
Author(s):  
Mathieu Brousseau-Nault ◽  
Jayachandran N. Kizhakkedathu ◽  
Hugh Kim
Keyword(s):  
Pilot Study ◽  
Chronic Periodontitis ◽  
Platelet Factor 4 ◽  
Platelet Factor
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