Interlimb Coordination in Patients with Parkinson’s Disease: Learning Capabilities and the Importance of Augmented Visual Information

2019 ◽  
pp. 273-276
Author(s):  
Sabine M. P. Verschueren ◽  
Stephan P. Swinnen ◽  
Rene Dom
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Visual Information ◽  
Interlimb Coordination ◽  
Learning Capabilities

Persons with Parkinson's disease show impaired interlimb coordination during backward walking

2021 ◽  
Author(s):  
Grace K. Kellaher ◽  
Sidney T. Baudendistel ◽  
Ryan T. Roemmich ◽  
Matthew J. Terza ◽  
Chris J. Hass
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Interlimb Coordination ◽  
Backward Walking

Increased Visual Dependence in Parkinson's Disease

2002 ◽  
Vol 95 (3_suppl) ◽  
pp. 1106-1114 ◽  
Author(s):  
Jean Philippe Azulay ◽  
Serge Mesure ◽  
Bernard Amblard ◽  
Jean Pouget
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gait Analysis ◽  
Visual Information ◽  
Frontal Plane ◽  
Normal Subjects ◽  
Visual Control ◽  
Subjective Vertical ◽  
Visual Vertical ◽  
Visual Dependence

The present study tested the hypothesis that there is increased visual dependence perceptually in patients with Parkinson's disease. We also evaluated whether the visual control of posture and locomotion was related to perceptual visual field dependence. 21 patients with idiopathic Parkinson's disease and 22 age-matched normal subjects were compared on judgment of the visual vertical using the Rod-and-Frame test with visual perturbations in the frontal plane with a tilted frame. Patients had significantly larger errors than controls in the estimation of the subjective vertical. In the same experiment, we performed a posture and a gait analysis in both groups. Posturographic evaluation did not indicate significant differences in unsteadiness between patients and controls. Gait analysis indicated a typical pattern of reduced velocity, shortened stride length, and normal step width. A significant correlation of .89 was found only in the Parkinsonian group between their errors in estimating subjective visual vertical and the Romberg quotient evaluating visual contribution to postural control. No specific locomotor pattern was correlated with visual dependence. Considering our results and previous reports on the visual control of posture, we conclude that patients with Parkinson's disease showed a significantly increased dependence upon visual information both perceptually and motorically, with an increased perceptual visual dependence in the patients being predictive of an equivalent visual dependence or visual control of posture and equilibrium.

scholarly journals Dissociation of Neural Mechanisms for Intersensory Timing Deficits in Parkinson’s Disease

2014 ◽  
Vol 2 (2) ◽  
pp. 145-168 ◽  
Author(s):  
Deborah L. Harrington ◽  
Gabriel N. Castillo ◽  
Jason D. Reed ◽  
David D. Song ◽  
Irene Litvan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Functional Connectivity ◽  
Visual Information ◽  
Anterior Insula ◽  
Visual Signals ◽  
Controlled Attention ◽  
Cortical Regions ◽  
Attention Demands

This study investigated the ability of individuals with Parkinson’s disease (PD) to synthesize temporal information across the senses, namely audition and vision. Auditory signals (A) are perceived as lasting longer than visual signals (V) when they are compared together, since attention is captured and sustained more easily than for visual information. We used the audiovisual illusion to probe for disturbances in brain networks that govern the resolution of time in two intersensory conditions that putatively differ in their attention demands. PD patients and controls judged the relative duration of successively presented pairs of unimodal (AA, VV) and crossmodal (VA, AV) signals whilst undergoing fMRI. There were four main findings. First, underestimation of time was exaggerated in PD when timing depended on controlled attention (AV), whereas subtle deficits were found when audition dominated and attention was more easily sustained (VA). Second, group differences in regional activation were observed only for the AV-unimodal comparison, where the PD group failed to modulate basal ganglia, anterior insula, and inferior cerebellum activity in accord with the timing condition. Third, the intersensory timing conditions were dissociated by patterns of abnormal functional connectivity. When intersensory timing emphasized controlled attention, patients showed weakened connectivity of the cortico-thalamus-basal ganglia (CTBG) circuit and the anterior insula with widespread cortical regions, yet enhanced cerebellar connectivity. When audition dominated intersensory timing, patients showed enhanced connectivity of CTBG elements, the anterior insula, and the cerebellum with the caudate tail and frontal cortex. Fourth, abnormal connectivity measures showed excellent sensitivity and specificity in accurately classifying subjects. The results demonstrate that intersensory timing deficits in PD were well characterized by context-dependent patterns of functional connectivity within a presumed core timing system (CTBG) and a ventral attention hub (anterior insula), and enhanced cerebellar connectivity irrespective of the hypothesized attention demands of timing.

scholarly journals Event-Related Potentials in Parkinson’s Disease Patients with Visual Hallucination

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Yang-Pei Chang ◽  
Yuan-Han Yang ◽  
Chiou-Lian Lai ◽  
Li-Min Liou
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Function ◽  
Visual Information ◽  
Event Related Potentials ◽  
Executive Dysfunction ◽  
Visual Spatial ◽  
Related Potentials ◽  
Neuropsychological Investigation ◽  
The Mean

Using neuropsychological investigation and visual event-related potentials (ERPs), we aimed to compare the ERPs and cognitive function of nondemented Parkinson’s disease (PD) patients with and without visual hallucinations (VHs) and of control subjects. We recruited 12 PD patients with VHs (PD-H), 23 PD patients without VHs (PD-NH), and 18 age-matched controls. All subjects underwent comprehensive neuropsychological assessment and visual ERPs measurement. A visual odd-ball paradigm with two different fixed interstimulus intervals (ISI) (1600 ms and 5000 ms) elicited visual ERPs. The frontal test battery was used to assess attention, visual-spatial function, verbal fluency, memory, higher executive function, and motor programming. The PD-H patients had significant cognitive dysfunction in several domains, compared to the PD-NH patients and controls. The mean P3 latency with ISI of 1600 ms in PD-H patients was significantly longer than that in controls. Logistic regression disclosed UPDRS-on score and P3 latency as significant predictors of VH. Our findings suggest that nondemented PD-H patients have worse cognitive function and P3 measurements. The development of VHs in nondemented PD patients might be implicated in executive dysfunction with altered visual information processing.

scholarly journals Dopamine and eye movement control in Parkinson’s disease: deficits in corollary discharge signals?

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e6038 ◽  
Author(s):  
Henry Railo ◽  
Henri Olkoniemi ◽  
Enni Eeronheimo ◽  
Oona Pääkkönen ◽  
Juho Joutsa ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Eye Movements ◽  
Eye Movement ◽  
Visual Information ◽  
Early Stage ◽  
Movement Control ◽  
Saccadic Eye Movements ◽  
Corollary Discharge ◽  
Motor Deficits

Movement in Parkinson’s disease (PD) is fragmented, and the patients depend on visual information in their behavior. This suggests that the patients may have deficits in internally monitoring their own movements. Internal monitoring of movements is assumed to rely on corollary discharge signals that enable the brain to predict the sensory consequences of actions. We studied early-stage PD patients (N = 14), and age-matched healthy control participants (N = 14) to examine whether PD patients reveal deficits in updating their sensory representations after eye movements. The participants performed a double-saccade task where, in order to accurately fixate a second target, the participant must correct for the displacement caused by the first saccade. In line with previous reports, the patients had difficulties in fixating the second target when the eye movement was performed without visual guidance. Furthermore, the patients had difficulties in taking into account the error in the first saccade when making a saccade toward the second target, especially when eye movements were made toward the side with dominant motor symptoms. Across PD patients, the impairments in saccadic eye movements correlated with the integrity of the dopaminergic system as measured with [123I]FP-CIT SPECT: Patients with lower striatal (caudate, anterior putamen, and posterior putamen) dopamine transporter binding made larger errors in saccades. This effect was strongest when patients made memory-guided saccades toward the second target. Our results provide tentative evidence that the motor deficits in PD may be partly due to deficits in internal monitoring of movements.

scholarly journals Time resolution for visual information processing in Parkinson's disease

1998 ◽  
Vol 65 (6) ◽  
pp. 921-923
Author(s):  
E. Mendez ◽  
M. Sabate ◽  
P. Garcia-Baez ◽  
C. Santana ◽  
M. Rodriguez
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Information Processing ◽  
Time Resolution ◽  
Visual Information ◽  
Visual Information Processing

scholarly journals Postural instability in subjects with parkinson’s disease undergoing different sensory pitfalls

2017 ◽  
Vol 18 (4) ◽  
Author(s):  
Thaís Cardoso Da Silva ◽  
Lilian Assunção Felippe ◽  
Rodrigo Luiz Carregaro ◽  
Gustavo Christofoletti
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Visual Information ◽  
Postural Stability ◽  
Body Position ◽  
Postural Instability ◽  
Sensory Stimuli ◽  
Eyes Closed ◽  
The Impact ◽  
Anterior Posterior

AbstractPurpose. Previous research has reported postural instability in subjects with Parkinson’s disease (PD). However, there are still doubts about the effect of sensory stimuli on one’s balance. In this study, we further investigated the stabilometric measures of individuals with PD, analysing the impact of different sensory stimuli on the outcomes. Methods. The total of 26 participants (13 with PD and 13 matched control peers) were submitted to 8 sensorimotor dynamics differing in relation to support base (30 cm vs. 10 cm, feet in parallel vs. feet in semi-tandem position), contact surface (foam vs. no foam), and visual conditions (eyes open vs. eyes closed). The measures used to assess one’s balance were body position in space, area of support base, and velocity of postural control. The variables involved the anterior-posterior and the mediolateral axes. Participants with PD were evaluated during the off medication state. Mann-Whitney U test and Friedman’s test were applied to carry out inter- and intra-group comparisons. Significance was set at 5%. Results. Cross-sectional analyses illustrated that tasks with sensory pitfalls impacted postural stability to a larger extent in PD subjects. The differences were found in anterior-posterior body position, area of support base, anterior-posterior velocity, and mediolateral velocity. Complementary analyses confirmed considerable instability on balance when support bases were small and visual information was absent (p < 0.05). Conclusions. The current results confirm worse postural stability response in subjects with PD and highlight that the interference of the sensory pitfalls is notable when individuals are off medication.

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