Precocious development

2018 ◽  
pp. 84-101
Author(s):  
Irma Brenman Pick
Keyword(s):  
Precocious Development

Abnormal Sexual Development: A Genetic and Endocrine Approach to Differential Diagnosis, by Daniel D. Federman, M.D. Philadelphia and London: W. B. Saunders Co., 1967, 206 pp., $8.75

PEDIATRICS ◽  
1969 ◽  
Vol 43 (2) ◽  
pp. 314-315
Author(s):  
Alfred M. Bongiovanni
Keyword(s):  
Differential Diagnosis ◽  
Sexual Development ◽  
Sexual Differentiation ◽  
Gonadal Development ◽  
Medical Texts ◽  
General Physicians ◽  
Precocious Development

There is much duplication in the area of medical texts, and so-called monographs often yield little that is not to be found in standard textbooks. Not so with Dr. Federman, who brings a special and personal flavor to his subject. He states that his monograph is "written for general physicians" and indeed the presentation is marked by clarity and breadth. He begins with a succinct description of normal sexual differentiation, proceeding to cytogenetics, disorders of gonadal development (appropriately subdivided), disorders of fetal endocrinology, and disorders of puberty, including delayed and precocious development.

Development and tissue distribution of sucrase-isomaltase mRNA in rats

1990 ◽  
Vol 258 (1) ◽  
pp. G52-G58 ◽  
Author(s):  
L. L. Leeper ◽  
S. J. Henning
Keyword(s):  
Enzyme Activity ◽  
Small Intestine ◽  
Northern Blot ◽  
Blot Analysis ◽  
Molecular Basis ◽  
Northern Blot Analysis ◽  
Sucrase Activity ◽  
Old Rats ◽  
Two Parameters ◽  
Precocious Development

Previous studies of sucrase-isomaltase (SI) activities have shown this complex to be absent in the suckling rat and to appear during the weaning period. We describe here the cloning of a heterologous SI cDNA and its use for the quantitation of SI mRNA as a first step toward understanding the molecular basis of SI development. A survey of RNA from 12 tissues of mature rats by Northern blot analysis showed a 6-kb band of SI mRNA only in the small intestine. Within the latter, both sucrase activity and SI mRNA peaked in the jejunum. Assay of jejunal tissue from developing rats showed sucrase activity and SI mRNA to be first detectable at 18 days, to rise in parallel through 24 days, and then to diverge a little (enzyme activity being lower) by 36 days. When glucocorticoid was administered to 10-day-old rats, neither sucrase activity nor SI mRNA was detectable 12 h later. Both parameters were readily detected 24 h postinjection, although the mRNA had risen relatively more than the enzyme activity. The two parameters increased in concert through 5 days postinjection and then plateaued. We conclude that, with respect to distribution along the intestine and to normal and precocious development, activities of SI in the rat are determined primarily by the abundance of its mRNA.

Precocious development of disaccharidases in the baboon intestine

2000 ◽  
Vol 118 (4) ◽  
pp. A294 ◽  
Author(s):  
Per T. Sangild ◽  
Katherine A. Berghorn ◽  
Peter W. Nathanielsz
Keyword(s):  
Precocious Development
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