Antibiotic resistance patterns among group B Streptococcus isolates: implications for antibiotic prophylaxis for early-onset neonatal sepsis

The objectives were to determine the prevalence of group B streptococcus (GBS) and to characterize antibiotic resistance patterns. All pregnant women presenting to the triage units at two urban hospitals during three intervals from 2001 to 2004 were included. Each interval lasted approximately four weeks. Swabs were inoculated into selective broth and cultured on tryptic soy agar with 5% sheep blood. GBS was identified using the StrepTex latex agglutination system. GBS positive cultures were tested for their resistance to ampicillin, erythromycin, clindamycin, and cefazolin. GBS was isolated from 154 (12.2%) of 1264 swabs collected during the study period. African-American women were more likely to be colonized with GBS than Caucasians and Hispanics. Resistance to routinely administered antibiotics was common, but there were no statistically significant increases in resistance to antibiotics over the study period. Ongoing surveillance of antibiotic resistance patterns is important in determining optimal prophylaxis and therapy.

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No increase in rates of early-onset neonatal sepsis by antibiotic-resistant group B Streptococcus in the era of intrapartum antibiotic prophylaxis

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2004.10.610 ◽

2005 ◽

Vol 192 (4) ◽

pp. 1167-1171 ◽

Cited By ~ 27

Author(s):

Katherine T. Chen ◽

Karen M. Puopolo ◽

Eric C. Eichenwald ◽

Andrew B. Onderdonk ◽

Ellice Lieberman

Keyword(s):

Antibiotic Prophylaxis ◽

Neonatal Sepsis ◽

Early Onset ◽

Group B Streptococcus ◽

Antibiotic Resistant ◽

Intrapartum Antibiotic Prophylaxis ◽

Resistant Group ◽

Intrapartum Antibiotic ◽

Group B

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CLINICAL AND MICROBIOLOGICAL FEATURES OF EARLY-ONSET NEONATAL SEPSIS IN PRETERM INFANTS

EUREKA Health Sciences ◽

10.21303/2504-5679.2020.001284 ◽

2020 ◽

Vol 3 ◽

pp. 13-19

Author(s):

Tetiana Klymenko ◽

Kateryna Kosenko

Keyword(s):

Preterm Infants ◽

Neonatal Sepsis ◽

Early Onset ◽

Group B Streptococcus ◽

Blood Cultures ◽

Coagulase Negative Staphylococcus ◽

Klebsiella Pneumonia ◽

Epidemiological Monitoring ◽

Sources Of Infection ◽

Group B

Early-onset neonatal sepsis (EONS) remains the leading cause of morbidity and mortality, especially among premature infants. Conducting high-quality epidemiological monitoring is an important condition for effective tactics treatment neonatal infections and improving the quality of medical care for this category of newborn. The aim. Determination of the value of microbiological triggers in the blood in various clinical options for EONS in preterm infants. Materials and methods. Clinical and microbiological data on 50 prematurely born newborns with EONS were selected. The analysis of the frequency of detected bacteremia, the distribution of pathogenic microorganisms and the clinical characteristics of neonatal sepsis. Results. In the study, sources of infection were detected in 94 % of cases. Positive blood cultures were obtained in 17 (34 %) newborns with EONS. 61.5 % of all cases of bacteremia were caused by coagulase-negative staphylococcus (CoNS). Gram-negative pathogens were detected in 23.5 % of positive blood cultures, representatives of this group were Escherichia coli and Klebsiella pneumonia. The overall mortality rate from EONS was 30 %. Conclusions. The incidence of sepsis confirmed by a positive blood culture was 34 %. The most common cause of EONS is CoNS, low incidence of group B Streptococcus sepsis has been established. The most frequent septicopymic sources of infection were the lungs, which is expressed in the high incidence (94 %) of X-ray pneumonia in the structure of the EONS.

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Early-onset neonatal sepsis and the implementation of group B streptococcus prophylaxis in a Brazilian maternity hospital: a descriptive study

The Brazilian Journal of Infectious Diseases ◽

10.1016/j.bjid.2016.09.013 ◽

2017 ◽

Vol 21 (1) ◽

pp. 92-97 ◽

Cited By ~ 5

Author(s):

Felipe Teixeira de Mello Freitas ◽

Gustavo Adolfo Sierra Romero

Keyword(s):

Neonatal Sepsis ◽

Early Onset ◽

Group B Streptococcus ◽

Descriptive Study ◽

Maternity Hospital ◽

Group B

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Bacteriological profile and sensitivity pattern of neonatal sepsis

Northern International Medical College Journal ◽

10.3329/nimcj.v8i1.32391 ◽

2017 ◽

Vol 8 (1) ◽

pp. 174-177

Author(s):

Rowshan Jahan Akhter ◽

Md Mahbubul Hoque ◽

BH Nazma Yasmeen ◽

MAK Azad Chowdhury

Keyword(s):

Antibiotic Resistance ◽

Neonatal Sepsis ◽

Antibiotic Sensitivity ◽

Neonatal Morbidity ◽

Diffusion Method ◽

Bacteriological Profile ◽

Sensitivity Pattern ◽

Haematological Profile ◽

Resistance Patterns ◽

Antibiotic Resistance Patterns

Introduction : Neonatal sepsis remains an important cause of neonatal morbidity and mortality in NICU setup and a major challenge for the neonatologists. The prevalent organisms and their antibiotic resistance patterns evolve with time and with the usage of antimicrobials.Aims and Objectives : To analyze the bacteriological profile and antibiotic resistance patterns of proven neonatal sepsis cases in Dhaka Shishu Hospital.Materials and Methods : The study was Prospective observational study. All the clinically suspected cases of Neonatal Sepsis admitted to the Neonatal word from January 2015 to December 2015 were included in the study. Clinically suspected cases of neonatal sepsis further evaluated with blood cultures and antibiotic susceptibility testing using the Kirby Bauer disc diffusion method. Data was collected for the following variables: Demographic profile, haematological profile, blood culture result and antibiotic sensitivity patterns.Results : Total 96 cases clinically suspected neonatal sepsis were included in the study. Among them 29 cases (30.21%) was culture positive septicemia. Klebsiella pneumoniae was the most common isolate accounting for 31.03% cases followed by Escherichia coli 27.59%. In Klebsiella infection most common sensitivity were Imipenum and Ciprofloxacin which were 77.78 and 33.33% respectively. In E.coli common sensitive drugs were Imipenum and Amikacin. In serratia common sensitive drugs were Imipenum, Netlmicin and Ciprofloxacin.Conclusion : K. pneumoniae was the most common pathogen. Most common sensitivity was Imipenum, Amikacin, Ciprofloxacin, Gentamicin, Netlmicin, and Ceftazidime,.Northern International Medical College Journal Vol.8(1) July 2016: 174-177

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