A Recent Update on Formulation and Development of Gastro-Retentive Drug Delivery Systems

2021 ◽  
Vol 14 (1) ◽  
pp. 5257-5270
Author(s):  
Abhishek Kumar ◽  
Meenakshi Bharkatiya
Keyword(s):  
Drug Delivery ◽  
Gastric Emptying ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Floating Drug Delivery ◽  
Novel Drug ◽  
Floating Drug Delivery Systems ◽  
Gastro Retentive

Oral route has been the most convenient and accepted  route of drug delivery. Owing to tremendous curative  benefits of the oral controlled release dosage forms are  being preferred as the interesting topic in pharmaceutical  field to achieved improved therapeutics advantages.  Gastro retentive drug delivery system is novel drug  delivery systems which has an upper hand owing to its  ability of prolonged retaining ability in the stomach and  thereby increase gastric residence time of drugs and also  improves bioavailability of drugs. Concept of novel drug  delivery system arose to overcome the certain aspect  related to physicochemical properties of drug molecule  and the related formulations. In this context, various  gastro retentive drug delivery systems have been used to  improve the therapeutic efficacy of drugs that have a  narrow absorption window, are unstable at alkaline pH,  are soluble in acidic conditions, and are active locally in  the stomach. Concept of novel drug delivery system  arose to overcome the certain aspect related to  physicochemical properties of drug molecule and the  related formulations. Various approaches are currently  used including gastro retentive floating drug delivery  systems, swelling and expanding system, polymeric bio  adhesive systems, modified shape systems, high density  system and other delayed gastric emptying devices.  Moreover, future perspectives on this technology are  discussed to minimize the gastric emptying rate in both  the fasted and fed states. The present review briefly  addresses the physiology of the gastric emptying  process with respect to floating drug delivery systems.  The purpose of this review is to bring together the recent  literature with respect to the method of preparation, and  various parameters affecting the performance and  characterization of floating microspheres. Attempt has  been made to summarize important factors controlling  gastro retentive drug delivery systems. Overall, this  review may inform and guide formulation scientists in  designing the gastro retentive drug delivery system.

scholarly journals Comprehensive review on characterizations and application of gastro-retentive floating drug delivery system

2021 ◽  
Vol 7 (1) ◽  
pp. 035-044
Author(s):  
Kajal D. Chaudhari ◽  
Minakshee G. Nimbalwar ◽  
Nikita S. Singhal ◽  
Wrushali A. Panchale ◽  
Jagdish V. Manwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gastric Emptying ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Dosage Forms ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System ◽  
Floating Drug Delivery Systems ◽  
Gastro Retentive

Current pharmaceutical situation focuses on the preparation of gastro-retentive floating drug delivery system (GRFDDS). This systems has gained noteworthy interest in the past decades. These are the low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. GRFDDS is used to delay the residence time of delivery in stomach. The controlled gastric retention of solid dosage forms may be achieved by the mechanism of mucoadhesion, floatation, sedimentation, expansion, modified shape systems or by the administration of pharmacological agents that delaying gastric emptying. This results in targeting of release of drug at a specific site for the systemic or local effects. GRDDS is used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. Some floating drug delivery systems have shown the capability to accommodate these variations without affecting drug release. This review mainly focuses characterizations and application of gastro-retentive floating drug delivery systems.

A Review on Floating Multi-particulate Drug Delivery System

2021 ◽  
pp. 3987-3992
Author(s):  
Suraj B. Pund ◽  
Vishwas C. Bhagat ◽  
Madhuri T. Deshmukh ◽  
Deepak P. Kardile ◽  
Rajkumar V. Shete
Keyword(s):  
Drug Delivery ◽  
Gastric Emptying ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gastric Retention ◽  
Pharmaceutical Dosage Form ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

The objective of writing this review on Floating Drug Delivery Systems (FDDS) was to accumulate new work with a special focus on the primary floatation mechanism for gastric retention. Drug delivery systems are those that instantly float on contact with gastric fluids and present promising approaches to improve the bioavailability of drugs with absorption windows in the stomach or upper small intestine, imbalanced in the intestinal or colonic environment, and exhibit low solubility at high pH standards. It is a novel drug delivery system that takes full advantage of effectiveness and compliance. Physical problems such as short gastric residence time and unpredictable gastric emptying time were overcome with the use of floating dosage forms that provide the possibility of local and systemic effects. The floating drug delivery system allows prolonged and continuous entry of the drug into the upper part of the gastric retention pathway and increases the bioavailability of the medication characterized by a narrow absorption window. This review provides detailed information on the pharmaceutical basis of its Introduction, Advantages, Disadvantages, Factors Affecting Gastric Emptying, and Criteria for Suitable Drug Products for Floating Gastric-Retention, Classification of Floating Multiparticulate Drug Delivery System, and Characterization of Floating Multiparticulate Drug Delivery System. These systems are beneficial for various difficulties encountered during the development of a pharmaceutical dosage form and the future potential of FDDS. This review article has attempted to announce to readers about the floating drug delivery system.

scholarly journals FLOATING TABLETS AND ITS POLYMERS

2018 ◽  
Vol 8 (5-s) ◽  
pp. 16-24 ◽  
Author(s):  
Shaika Saadia Zubedi ◽  
Shahid Mohammed
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Oral Drug ◽  
Advantages And Disadvantages ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery Systems ◽  
Natural And Synthetic

Oral drug delivery system is the most preferred route of administration for drug delivery. In the development of the drug delivery system many components play important role. Polymers are amongst those components which have evolved with the drug delivery system. Polymers are the macromolecule compound containing many monomer units joined to each other by bonds. The floating drug delivery systems (FDDS) become an additional advantage for drugs that are absorbed primarily in the upper segments of gastrointestinal (GI) tract, i.e., the stomach, duodenum and jejunum. The purpose of writing this review on floating drug delivery systems (FDDS) was to focus on the types of floating drug delivery systems, principal and mechanism of floatation to achieve gastric retention and polymers used in floating Drug delivery systems. Polymers used in the drug delivery system are of two types Natural and Synthetic based on their origin. Both types of the polymers have some advantages and disadvantages. This particular article gives information about the different types of natural and synthetic polymer used in the drug delivery system. Natural polymers like guar gum, chitosan, xanthan gum, Gellan gum and sodium alginate are mentioned in the article. Synthetic polymers mentioned are HPMC, Eudragit, and Ethylcellulose. Keywords: Floating Drug Delivery System, Polymers, Natural gums, HPMC.

Short Review on Novel Dosage Form

2021 ◽  
pp. 301-303
Author(s):  
Tushar N. Sonawane ◽  
Pradip D. Dhangar ◽  
Sagar D Patil ◽  
Azam Z. Shaikh
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Drug Effects ◽  
Short Review ◽  
Delivery Systems ◽  
The Novel ◽  
Novel Drug Delivery System ◽  
Novel Drug

Novel Drug Delivery Systems are one of the widely use delivery system in the presence scenario. Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems. In the form of a Novel Drug Delivery System an existing drug molecule can get a new life. The novel drug delivery system is Increases bioavailability and it Can be used for long-term treatments of chronic illness, Sustained maintenance of plasma drug levels as well as it Decreased adverse drug effects in the total amount of drugs required thus reducing side effects it Improved patient compliance due to reduction in number and frequency of doses required. There is less damage sustained by normal tissue due to targeted drug delivery. In this paper our main focus to give the throughout knowledge of some newer (Novel drug delivery system) to understand the concept of the Novel dossage form.

scholarly journals A REVIEW ON AN EMERGIN TREND BILAYER FLOATING DRUG DELIVERY SYSTEM

2021 ◽  
Vol 11 (2) ◽  
pp. 44-49
Author(s):  
ANJALI CHOURASIYA ◽  
◽  
NARENDRA GEHALOT ◽  
SURESH CHANDRA MAHAJAN ◽  
◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Bilayer Tablets ◽  
Bilayer Tablet ◽  
Conventional Drug ◽  
Gastro Retentive

NDDS is advanced drug delivery system which improves drug potency, control drug release to give a sustained therapeutic effect, provide greater safety, finally it is to target a drug specifically to a desired tissue. Novel drug delivery system have been developed to overcome the limitation of conventional drug delivery systems, such as of gastric retention by decreasing fluctuations in the concentration of the drug in blood,resulting in the reduction in unwanted toxicity and poor efficiency. As compared to traditional dosage forms bilayer tablets are more efficient for sequential release of two drugs that can be different or identical. Bilayer tablet is also capable of separating two incompatible substances and also for sustained release. Gastro retentive drug delivery system retains the period of dosage forms in the stomach or upper gastro intes-tinal tract ,as to improve bioavailability and the therapeutic efficacy of the drugs. Mainly the bilayer drug delivery system is suitable for drugs whose therapethic windows are narrow in the gastrointestinal tract (GIT) and also they have low elimination half life: 3-4 h. The purpose of this review is to disclose the challenges faced during the formulation of bilayer tablets. Finally, the whole article is firmly analyzed in a concluding paragraph. KEYWORDS: Conventional drug delivery systems, Bilayer tablet, Gastro retentive, Bioavailability

scholarly journals Floating drug delivery system- a review

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Sharma Anjali ◽  
Sharma Devkant
Keyword(s):  
Drug Delivery ◽  
Gastric Emptying ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gastric Retention ◽  
Residence Times ◽  
Principal Mechanism ◽  
Floating Drug Delivery ◽  
Floating Systems ◽  
Floating Drug Delivery Systems

In the recent years, scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming various physiological problems such as short gastric residence times and unpredictable gastric emptying times. Several approaches are utilized in the prolongation of the gastric residence times, such as floating drug delivery systems, swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems and other delayed gastric emptying devices. Floating Drug Delivery Systems (FDDS) is one amongst the GRDFs used to achieve prolonged gastric residence time. The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in-vitro techniques, in- vivo studies to evaluate the performance and application of floating systems, and applications of these systems.

scholarly journals An updated review on pharmacosomes, a vesicular drug delivery system

2019 ◽  
Vol 9 (1-s) ◽  
pp. 393-402 ◽  
Author(s):  
Bommala Supraja ◽  
Saritha Mulangi
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Alternative Methods ◽  
Therapeutic Window ◽  
Lipid Molecule ◽  
Novel Drug

Novel drug delivery system mainly consents about achieving the targeted concentration to release the drug at targeted site by using carrier system, altering the structure and microenvironment around the drug. Especially drugs which are having narrow therapeutic window are difficult to formulate, with the advantage of novel drug delivery systems like particulate, polymeric carrier, macromolecular and cellular carriers. They are used to reduce complications as well as release the drug in a determined fusion at targeted site. In vesicular drug delivery system drug binds covalently to the lipid molecule by which the drug release is in a controlled manner and also drugs which are of hydrophilic or lipophilic nature can be delivered by using vesicular drug delivery systems. The release of drug from the vesicles depends on the physicochemical properties of both the drug and carrier. Vesicular drug delivery includes liposomes, niososmes, transferosomes, pharmacosomes, electrosomes, ethosomes etc. Of all these drug delivery systems pharmacosomes are having more advantages like no leakage or loss of drug, stability, high entrapment efficiency etc, pharmacosomes may be hexagonal aggregates , ultrafine vesicular and micellar forms. Both synthetic and natural drugs which are facing difficulties like low solubility and low permeability can be effectively formulated and can achieve required pharmacokinetic and pharmacodynamic parameters. Pharmacosomes are prepared by hand shaking method, ether injection, solvent evaporation method, anhydrous co-solvent lyophilyzation, supercritical fluid approach and other alternative methods they are characterized by complex determination, surface morphology, drug entrapment, solubility, drug lipid compatibility, crystal state measurement, dissolution studies and in vitro drug release rate. Keywords: Pharmacosomes, covalently, vesicular drug delivery system, hexagonal aggregates, micellar, ultrafine.

scholarly journals FLOATING DRUG DELIVERY SYSTEM: A REVIEW

2020 ◽  
Vol 4 (8) ◽  
Author(s):  
Vijay Sharma ◽  
D.S. Rathore ◽  
Amit Kumar
Keyword(s):  
Drug Delivery ◽  
Gastric Emptying ◽  
Drug Delivery Systems ◽  
Oral Drug Delivery ◽  
Delivery Systems ◽  
Oral Drug ◽  
Gastric Residence Time ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System ◽  
Floating Drug Delivery Systems

In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. The different strategies used in the development of FDDS by constructing the effervescent and noneffervescent type of floating tablets basis of which is buoyancy mechanism. FDDS is a method to deliver the drugs that are active locally with a narrow absorption window in the upper gastrointestinal tract, unstable in the lower intestinal environment, and possess low solubility with higher pH values. The recent developments in floating drug delivery systems are containing the physiological and formulation variables impacting on gastric retention time, approaches to formulating of single-unit and multiple-unit floating systems, and their classification and formulation aspects are discussed in detail. This review also summarizes evaluation parameters and application of floating drug delivery systems. Keywords: Floating drug delivery systems (FDDS), Gastric residence time, Swelling index, Buoyancy.

Floating Drug Delivery Systems

2009 ◽  
Vol 2 (3) ◽  
pp. 595-604
Author(s):  
Jagadeesh Nadigoti ◽  
Shayeda
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
New Era ◽  
Gastric Residence Time ◽  
Floating Drug Delivery ◽  
Recent Developments ◽  
Multiple Unit ◽  
Novel Drug ◽  
Floating Drug Delivery Systems

Management of illness through medication is entering a new era in which growing number of novel drug delivery systems are being employed and are available for therapeutic use. Oral sustained release gastro-retentive dosage forms (GRDFs) offer many advantages for drugs with absorption from upper parts of gastrointestinal tract and for those acting locally in the stomach, improving the bioavailability of the medication. Floating Drug Delivery Systems (FDDS) is one amongst the GRDFs used to achieve prolonged gastric residence time. Multiple unit FDDS avoid “all-or-nothing” gastric emptying nature of single unit systems. Apart from the background, formulation aspects and evaluation of FDDS, recent developments are also covered in this review.

Sign in / Sign up

Export Citation Format

Share Document