Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.

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Mesoporous silica nanoparticle based nano drug delivery systems: synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility

Journal of Materials Chemistry ◽

10.1039/c0jm03851b ◽

2011 ◽

Vol 21 (16) ◽

pp. 5845 ◽

Cited By ~ 499

Author(s):

Qianjun He ◽

Jianlin Shi

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Mesoporous Silica ◽

Drug Delivery Systems ◽

Silica Nanoparticle ◽

Controlled Drug Release ◽

Delivery Systems ◽

Mesoporous Silica Nanoparticle ◽

Nano Drug Delivery

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Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies

Journal of Controlled Release ◽

10.1016/j.jconrel.2020.08.012 ◽

2020 ◽

Vol 327 ◽

pp. 316-349 ◽

Cited By ~ 5

Author(s):

Farshad Moradi Kashkooli ◽

M. Soltani ◽

Mohammad Souri

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Cancer Drug ◽

Nano Drug Delivery ◽

Anti Cancer

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Chitosan Nanoparticles-Insight into Properties, Functionalization and Applications in Drug Delivery and Theranostics

Molecules ◽

10.3390/molecules26020272 ◽

2021 ◽

Vol 26 (2) ◽

pp. 272

Author(s):

Jhanvi Jhaveri ◽

Zarna Raichura ◽

Tabassum Khan ◽

Munira Momin ◽

Abdelwahab Omri

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery Systems ◽

Chitosan Nanoparticles ◽

Controlled Drug Release ◽

Drug Regimen ◽

Delivery Systems ◽

Important Place ◽

Nano Drug Delivery ◽

Insight Into

Nanotechnology-based development of drug delivery systems is an attractive area of research in formulation driven R&D laboratories that makes administration of new and complex drugs feasible. It plays a significant role in the design of novel dosage forms by attributing target specific drug delivery, controlled drug release, improved, patient friendly drug regimen and lower side effects. Polysaccharides, especially chitosan, occupy an important place and are widely used in nano drug delivery systems owing to their biocompatibility and biodegradability. This review focuses on chitosan nanoparticles and envisages to provide an insight into the chemistry, properties, drug release mechanisms, preparation techniques and the vast evolving landscape of diverse applications across disease categories leading to development of better therapeutics and superior clinical outcomes. It summarizes recent advancement in the development and utility of functionalized chitosan in anticancer therapeutics, cancer immunotherapy, theranostics and multistage delivery systems.

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Formulation, Development and Characterization of Floating Beads of Diltiazem Hydrochloride

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v6i1.8883 ◽

2016 ◽

Vol 6 (1) ◽

Author(s):

Anamika Saxena Saxena ◽

Santosh Kitawat ◽

Kalpesh Gaur ◽

Virendra Singh

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery Systems ◽

Entrapment Efficiency ◽

Repeated Administration ◽

Alginate Beads ◽

Delivery Systems ◽

Sem Analysis ◽

Formulation Development

The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and nontoxic for a prolonged period. Various attempts have been made to develop gastroretentive delivery systems such as high density system, swelling, floating system. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. Gastric emptying is a complex process and makes in vivo performance of the drug delivery systems uncertain. In order to avoid this variability, efforts have been made to increase the retention time of the drug-delivery systems for more than 12 hours. The floating or hydrodynamically controlled drug delivery systems are useful in such application. Background of the research: Diltiazem HCL (DTZ), has short biological half life of 3-4 h, requires rather high frequency of administration. Due to repeated administration there may be chances of patient incompliance and toxicity problems. Objective: The objective of study was to develop sustained release alginate beads of DTZ for reduction in dosing frequency, high bioavailability and better patient compliance. Methodology: Five formulations prepared by using different drug to polymer ratios, were evaluated for relevant parameters and compared. Alginate beads were prepared by ionotropic external gelation technique using CaCl2 as cross linking agent. Prepared beads were evaluated for % yield, entrapment efficiency, swelling index in 0.1N HCL, drug release study and SEM analysis. In order to improve %EE and drug release, LMP and sunflower oil were used as copolymers along with sodium alginate.

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Recent Advances of Mesoporous Silica Based Multifunctional Nano Drug Delivery Systems

ACTA AGRONOMICA SINICA ◽

10.3724/sp.j.1206.2013.00303 ◽

2013 ◽

Vol 40 (10) ◽

pp. 1014

Author(s):

Xiao-Hong HAO ◽

Cui-Miao ZHANG ◽

Xiao-Long LIU ◽

Xing-Jie LIANG ◽

Guang JIA ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Recent Advances ◽

Nano Drug Delivery

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Current HPLC Methods for Assay of Nano Drug Delivery Systems

Current Topics in Medicinal Chemistry ◽

10.2174/1568026616666161222112305 ◽

2017 ◽

Vol 17 (13) ◽

pp. 1588-1594 ◽

Cited By ~ 3

Author(s):

Serife Evrim Kepekci Tekkeli ◽

Mustafa Volkan Kiziltas

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Nano Drug Delivery

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Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

Current Nanoscience ◽

10.2174/1573413714666180222134742 ◽

2018 ◽

Vol 14 (5) ◽

pp. 432-439 ◽

Cited By ~ 1

Author(s):

Juliana M. Juarez ◽

Jorgelina Cussa ◽

Marcos B. Gomez Costa ◽

Oscar A. Anunziata

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Therapeutic Efficacy ◽

Drug Delivery Systems ◽

Controlled Drug Release ◽

Delivery Systems ◽

The Body ◽

Fickian Diffusion ◽

Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

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An overview of Osmotic Drug Delivery System: An update review

International Journal of Bioassays ◽

10.21746/ijbio.2017.07.001 ◽

2017 ◽

Vol 6 (7) ◽

pp. 5426 ◽

Cited By ~ 2

Author(s):

Hiren J. Patel ◽

Vaishnavi P. Parikh

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Life Cycle Management ◽

Delivery Systems ◽

Osmotic Pump ◽

Factors Affecting ◽

Advantages And Disadvantages ◽

New Chemical Entities ◽

History Of ◽

Novel Drug

The pharmaceutical industry has faced several marked challenges in order to bring new chemical entities (NCEs) into the market over the past few decades. Various novel drug delivery approaches have been used as a part of life cycle management from which Osmotic drug delivery systems look the most promising one. After discussing the history of osmotic pump development, this article looks at the principles, advantages and disadvantages of osmotic drug delivery systems. Then, the basic components of osmotic pump and factors affecting the design of oral osmotic drug delivery systems are discussed in detail. In the later part of the manuscript, various types of osmotic pumps available in the market and evaluation methods for osmotic drug delivery systems are discussed in detail.

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