scholarly journals Assessing the Clinical Utility of Haptoglobin to Creatinine Ratio as a Test for Detecting Nephropathy among Type 2 Diabetic Patients

2019 ◽  
Vol 2 (3) ◽  
pp. 180-184
Author(s):  
IY Mohammed ◽  
AO Busari ◽  
MB Ahmad
Keyword(s):  
Quantitative Determination ◽  
Regression Model ◽  
Clinical Utility ◽  
Diabetic Patients ◽  
Creatinine Ratio ◽  
Type 2 Diabetic Patients ◽  
Urine Albumin ◽  
Type 2 Diabetic

Diabetic nephropathy is the leading cause of diabetic complications and end-stage renal disease worldwide, especially in Nigeria. This study assessed the clinical utility of urine Albumin to Creatinine ratio (UACR) and urine Haptoglobin to Creatinine ratio (UHCR) in detecting nephropathy among type 2 diabetic patients attending Aminu Kano Teaching Hospital. Eighty (80) type 2 diabetic patients attending Aminu Kano Teaching Hospital were recruited for this study after excluding those with overt proteinuria. Blood sample was collected for quantitative determination of serum creatinine using Jaffe's method while the Urine sample was received for quantitative determination of urine albumin and urine haptoglobin levels. Linear regression model revealed a unit change in urine albumin to creatinine ratio (UACR) and urine haptoglobin to creatinine ratio (UHCR) with a significant reduction in estimated Glomerular Filtration Rate (eGFR) by 2.197ml/min and 27.969 ml/min respectively (p<0.05) when used while logistic regression model demonstrated that UHCR have 91.7% sensitivity, 95% specificity, 98% positive predictive value and 79% negative predictive compared to UACR with 83.3% sensitivity, 75% specificity, 91% positive predictive and 60% negative predictive. Based on these findings, UHCR is a good marker for detecting nephropathy in diabetic patients.

scholarly journals Assessing the Clinical Utility of Haptoglobin to Creatinine Ratio as a Test for Detecting Nephropathy among Type 2 Diabetic Patients

2019 ◽  
Vol 2 (3) ◽  
pp. 180-184
Author(s):  
IY Mohammed ◽  
AO Busari ◽  
MB Ahmad
Keyword(s):  
Quantitative Determination ◽  
Regression Model ◽  
Clinical Utility ◽  
Diabetic Patients ◽  
Creatinine Ratio ◽  
Type 2 Diabetic Patients ◽  
Urine Albumin ◽  
Type 2 Diabetic

Diabetic nephropathy is the leading cause of diabetic complications and end-stage renal disease worldwide, especially in Nigeria. This study assessed the clinical utility of urine Albumin to Creatinine ratio (UACR) and urine Haptoglobin to Creatinine ratio (UHCR) in detecting nephropathy among type 2 diabetic patients attending Aminu Kano Teaching Hospital. Eighty (80) type 2 diabetic patients attending Aminu Kano Teaching Hospital were recruited for this study after excluding those with overt proteinuria. Blood sample was collected for quantitative determination of serum creatinine using Jaffe's method while the Urine sample was received for quantitative determination of urine albumin and urine haptoglobin levels. Linear regression model revealed a unit change in urine albumin to creatinine ratio (UACR) and urine haptoglobin to creatinine ratio (UHCR) with a significant reduction in estimated Glomerular Filtration Rate (eGFR) by 2.197ml/min and 27.969 ml/min respectively (p<0.05) when used while logistic regression model demonstrated that UHCR have 91.7% sensitivity, 95% specificity, 98% positive predictive value and 79% negative predictive compared to UACR with 83.3% sensitivity, 75% specificity, 91% positive predictive and 60% negative predictive. Based on these findings, UHCR is a good marker for detecting nephropathy in diabetic patients.

scholarly journals Assessing the Clinical Utility of Haptoglobin to Creatinine Ratio as a Test for Detecting Nephropathy among Type 2 Diabetic Patients

2019 ◽  
Vol 2 (3) ◽  
pp. 180-184
Author(s):  
IY Mohammed ◽  
AO Busari ◽  
MB Ahmad
Keyword(s):  
Quantitative Determination ◽  
Regression Model ◽  
Clinical Utility ◽  
Diabetic Patients ◽  
Creatinine Ratio ◽  
Type 2 Diabetic Patients ◽  
Urine Albumin ◽  
Type 2 Diabetic

Diabetic nephropathy is the leading cause of diabetic complications and end-stage renal disease worldwide, especially in Nigeria. This study assessed the clinical utility of urine Albumin to Creatinine ratio (UACR) and urine Haptoglobin to Creatinine ratio (UHCR) in detecting nephropathy among type 2 diabetic patients attending Aminu Kano Teaching Hospital. Eighty (80) type 2 diabetic patients attending Aminu Kano Teaching Hospital were recruited for this study after excluding those with overt proteinuria. Blood sample was collected for quantitative determination of serum creatinine using Jaffe's method while the Urine sample was received for quantitative determination of urine albumin and urine haptoglobin levels. Linear regression model revealed a unit change in urine albumin to creatinine ratio (UACR) and urine haptoglobin to creatinine ratio (UHCR) with a significant reduction in estimated Glomerular Filtration Rate (eGFR) by 2.197ml/min and 27.969 ml/min respectively (p<0.05) when used while logistic regression model demonstrated that UHCR have 91.7% sensitivity, 95% specificity, 98% positive predictive value and 79% negative predictive compared to UACR with 83.3% sensitivity, 75% specificity, 91% positive predictive and 60% negative predictive. Based on these findings, UHCR is a good marker for detecting nephropathy in diabetic patients.

scholarly journals The study of dyslipidemia and its correlation with nephropathy in diabetes mellitus type 2 patients

2017 ◽  
Vol 4 (5) ◽  
pp. 1231
Author(s):  
Rakesh K. Sisodia ◽  
Archana Gupta ◽  
Neelima Singh
Keyword(s):  
Diabetic Nephropathy ◽  
P Value ◽  
Diabetic Patients ◽  
Creatinine Ratio ◽  
Type 2 Diabetic Patients ◽  
Albumin Creatinine Ratio ◽  
Urine Albumin ◽  
Lipid Abnormalities ◽  
Type 2 Diabetic

Background: Diabetic nephropathy is one of the most severe diabetic microangiopathies. The aim of this study was to evaluate the lipid abnormalities associated with different stages of proteinuria in type 2 diabetic patients.Methods: In this study 100 type 2 diabetic patients were subjected to detailed history, clinical examination, Serum lipid profile, urine albumin creatinine ratio and routine biochemical investigations.Results: Out of 100 patients were included in study, 41 patients were normoabluminuric, 37 patients were microalbuminuric and 22 patients were overt proteinuric. Most common dyslipidemia found in study is increased triglyceride (43%) followed by increased LDL (28). On comparing normoalbuminuric to overt proteinuric, a positive correlation found in increased triglyceride (P value < 0.001) and increases LDL (P value <0.001).Conclusions: Concluded that raised Triglyceride and LDL are associated with Diabetic Nephropathy.

scholarly journals Novel Tubular Biomarkers Predict Renal Progression in Type 2 Diabetes Mellitus: A Prospective Cohort Study

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Bancha Satirapoj ◽  
Kasemsan Aramsaowapak ◽  
Theerasak Tangwonglert ◽  
Ouppatham Supasyndh
Keyword(s):  
Diabetic Nephropathy ◽  
Rapid Decline ◽  
Diabetic Patients ◽  
Creatinine Ratio ◽  
Type 2 Diabetic Patients ◽  
Estimated Gfr ◽  
Cox Regression Analysis ◽  
Renal Progression ◽  
Type 2 Diabetic

Background.Tubulointerstitial injury is both a key feature of diabetic nephropathy and an important predictor of renal dysfunction. Novel tubular biomarkers related to renal injury in diabetic nephropathy could improve risk stratification and prediction.Methods.A total of 303 type 2 diabetic patients were followed up. The baseline urine values of cystatin-C to creatinine ratio (UCCR), angiotensinogen to creatinine ratio (UANG), NGAL to creatinine ratio (UNGAL), and KIM-1 to creatinine ratio (UKIM-1) were measured. The primary outcome was a decline in estimated GFR of ≥25% yearly from baseline.Results.Urine tubular biomarkers of UCCR, UANG, UNGAL, and UKIM-1 were significantly higher according to the degree of albuminuria and all were significantly higher among patients with rapid decline in estimated GFR of ≥25% yearly from baseline. All biomarkers predicted primary outcomes with ROC for UCCR of 0.72; 95% CI 0.64–0.79, for UANG of 0.71; 95% CI 0.63–0.79, for UNGAL of 0.64; 95% CI 0.56–0.72, and for UKIM-1 of 0.71; 95% CI 0.63–0.79. Using multivariate Cox regression analysis, the number of patients with rapid renal progression was higher among those in the upper quartiles of all biomarkers than in those in the lower quartiles.Conclusions. Type 2 diabetic patients with high levels of urine tubular biomarkers had a more rapid decline in renal function.

scholarly journals Analysis of the Associations between Vitamin D and Albuminuria orβ-Cell Function in Chinese Type 2 Diabetes

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Xiaoling Cai ◽  
Zhaoheng Hu ◽  
Ling Chen ◽  
Xueyao Han ◽  
Linong Ji
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Cell Function ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Albumin Creatinine Ratio ◽  
Urine Albumin ◽  
Vitamin D Supplement ◽  
Type 2 Diabetic

Objective. To investigate the associations of 25-(OH)D andβ-cell function or insulin resistance or albuminuria in Chinese type 2 diabetic patients.Methods. In total, 1408 type 2 diabetic patients without vitamin D supplement were included in this retrospective study.Results. Comparison between patients with and without 25-(OH)D deficiency indicated that, compared with patients with 25-(OH)D ≥ 50 nmol/L, patients with 25-(OH)D < 50 nmol/L showed a higher level of urine albumin-creatinine ratio (ACR) (90.15±10.30 mg/g versus52.79±14.97 mg/g). Multiple regression analysis indicated that 25-(OH)D was independently and negatively correlated with urine ACR (OR=0.985, 95%CI 0.972–0.999,P=0.03), adjusted by age, diabetic duration, HBP duration, SBP, HbA1c, creatinine, LDL-C, triglyceride, total cholesterol, and HDL-C. Compared with patients with normal level of urine ACR, patients with higher level of urine ACR showed a significant lower level of 25-(OH)D (34.49±13.52 nmol/L versus37.46±13.6 nmol/L,P=0.00). Analysis of the associations of 25-(OH)D andβ-cell function or insulin resistance showed that 25-(OH)D may not correlate withβ-cell function or insulin resistance.Conclusion. 25-(OH)D was independently associated with albuminuria in Chinese type 2 diabetic patients but was not associated withβ-cell function or insulin resistance.

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