scholarly journals Evaluation the relation between age at the time of diabetes diagnosis and Glutamic acid decarboxylase (GAD) antibody in non- overweight, obese diabetic individuals

2021 ◽  
pp. 39-44
Author(s):  
Thua Nguyen Tran
Keyword(s):  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Objective Evaluation ◽  
Cross Sectional Study ◽  
Acid Decarboxylase ◽  
Diabetic Patients ◽  
Diabetes Diagnosis ◽  
Sectional Study ◽  
Central Hospital ◽  
Cross Sectional

Objective: Evaluation the relation between age at the time of diabetes diagnosis and glutamic acid decarboxylase (GAD) antibody in non- overweight, obese diabetic individuals. Method: A cross-sectional study on 284 non overweight- obesity diabetic patients at Hue Central hospital from August 2017 to August 2019. All patients were measured autoantibodies glutamic acid decarboxylase (anti-GAD). GAD antibody- positive was determined when autoantibodies to GAD concentration was higher than 5 IU/mL. Clinical data (age, sex, weight, hight) were obtained. Age at the time of diabetes diagnosis was interviewed. Data were analysed by SPSS version 16.0 and Medcalc software. Results: The risk of glutamic acid decarboxylase (GAD) antibody- positive in non- overweight, obese diabetic individuals increased 2.7 time when aged at the time of diabetes diagnosis 50 and older. The cut-off of age at the time of diabetes diagnosis for detecting risk of glutamic acid decarboxylase (GAD) antibody- positive in non- overweight, obese diabetic individuals was 57. Conclusion: This study showed non- overweight, obese diabetic individuals should be screened for glutamic acid decarboxylase (GAD) antibody at aged 50 and older

scholarly journals Antibodies against glutamic acid decarboxylase and indices of insulin resistance and insulin secretion in nondiabetic adults: a cross-sectional study

2017 ◽  
Vol Volume 10 ◽  
pp. 179-185 ◽  
Author(s):  
Carlos O Mendivil ◽  
Freddy JK Toloza ◽  
Maria L Ricardo-Silgado ◽  
Martha C Morales-Alvarez ◽  
Jose O Mantilla-Rivas ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Secretion ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Cross Sectional Study ◽  
Acid Decarboxylase ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Open-angle glaucoma in diabetic patients’ prevalence and risk factors: a cross-sectional study in Sudan

2020 ◽  
Vol 8 (6) ◽  
pp. 2205
Author(s):  
Omyma Abbas Banaga Salih ◽  
Ehab Hamed
Keyword(s):  
Risk Factors ◽  
Open Angle Glaucoma ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Diabetes Diagnosis ◽  
Open Angle ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk ◽  
Diabetic Population

Background: Diabetic patients are at increased risk of glaucoma compared to the general population. Risk factors for glaucoma that is specific to diabetic patients include increased IOP, retinopathy and neovascular changes and years since diagnosis of diabetes. This cross-sectional study aims to report on the prevalence of glaucoma in diabetic patients in community diabetes centre in Sudan and examine associations with previously reported risk factors.Methods: A cross-sectional study was carried out in Omdurman specialised diabetic healthcare centre in Sudan. A total of 300 patients consented to participation. All patients filled in a survey for both demographics and diabetic disease history then had an assessment for glaucoma by an ophthalmologist. The assessment included examination of the anterior segment, optic nerve assessment and fundus examination using a stereoscopic slit lamp, intraocular pressure (IOP) measurement using tonometry, peripheral anterior chamber configuration and depth assessments using gonioscopy and central visual field assessment using perimetry.Results: Prevalence of open-angle glaucoma diagnosis was 2.8% among diabetic patients who were included in this study. Family history for glaucoma was significantly associated with increased risk of open-angle glaucoma (OR 5.67, 95% CI 1.74-18.45). Retinopathy was also associated with an increased risk of developing the condition (OR 3.1, 95% CI 1.11-8.51). Gender, years since diabetes diagnosis and medications did not have significant associations.Conclusions: Patients with diabetes are at increased risk of developing open-angle glaucoma, but the prevalence among the diabetic population attending community diabetes centre in Sudan remains low. Among different clinical determinants, diabetic retinopathy and genetic determinants may explain the increased risk in the diabetic population.

scholarly journals Association between Hyperhomocysteinemia and Thyroid Hormones in Euthyroid Diabetic Subjects

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Yun Zhang ◽  
Qiong Wang ◽  
Quanzhong Li ◽  
Ping Lu
Keyword(s):  
Blood Pressure ◽  
Fasting Glucose ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Diabetic Patients ◽  
Biomedical Data ◽  
Sectional Study ◽  
Free Triiodothyronine ◽  
Cross Sectional ◽  
Elderly Males

Objectives. The concept now emerging is that higher thyroid-stimulating hormone (TSH) and lower thyroid hormone levels within the euthyroid range may adversely affect atherosclerosis. The present study aimed to investigate the potential associations between thyroid parameters and hyperhomocysteinaemia in a cohort of euthyroid diabetic subjects.Material and Methods. Two hundred and seventy-three euthyroid diabetic subjects (167 males and 106 females) were consecutively recruited in this cross-sectional study. Clinical and biomedical data was collected.Results. TSH level was higher in females than males. Compared to normal-homocysteine group, hyperhomocysteinaemia group was more likely to be elderly, males, with longer diabetes history, and with lower diastolic blood pressure. Free thyroxine (FT4) level was lower in hyperhomocysteinaemia group than in normal-homocysteine group; however, it was not statistically significant. Adjusted for age, sex, body mass index, duration of diabetes, blood pressure, fasting glucose, total cholesterol, and triglyceride in logistic regression analyses, hyperhomocysteinaemia was significantly correlated with FT4 (P=0.021). No significant association was found with TSH or free triiodothyronine. When analyzed in subjects with TSH < 2.5 uIU/mL separately, we got similar results.Conclusions. In conclusion, we identified a relation between hyperhomocysteinemia and FT4 in a group of euthyroid diabetic patients.

THE PREVALENCE OF HYPERTENSION IN DIABETIC AND NON-DIABETIC STROKE PATIENTS IN COMMUNITY HOSPITAL OF DISTRICT SWAT, PAKISTAN

1969 ◽  
Vol 2 (2) ◽  
pp. 187-191
Author(s):  
Sahibzada Saeed Jan ◽  
Taj Muhammad Khan ◽  
Alamzeb ◽  
Izaz-urrahman ◽  
Amanullah ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Community Hospital ◽  
Macrovascular Disease ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Elevated Blood ◽  
Sectional Study ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Hospital District

Background: As hypertension is the most important risk factor for stroke, it is generally considered to beasymptomatic condition and require lifetime therapy which may include chemotherapy and lifestylechanges. Hypertension also clearly contributes to the risk of macrovascular disease in patients with type-IIdiabetes mellitus. Therefore, the present study was conducted to evaluate the prevalence of hypertension indiabetic and non-diabetic stroke patients in community hospital district Swat. Methodology: This was a cross-sectional study, comprised of 100 subjects, 50 were diabetic and 50 werenon-diabetic stroke patients of ages between 28 to 90 years. The blood sugar (random and fasting), bloodpressure (systolic and diastolic) of Diabetic stroke subjects were compared with Non-diabetic strokesubjects. Results: The prevalence of hypertension was significantly high in diabetic stroke subject as compared tonon-diabetic stroke subjects. Conclusion: Diabetic patients with persistently elevated blood pressure are more prone to develop stroke ascompared to non diabetic with hypertension KEYWORDS:Stroke, Diabetes mellitus, hypertension.

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