scholarly journals Placenta Morphological and Amniotic Fluid Biochemical Changes Associated with Mid-Gestation Single and Twin Pregnancies in Red Sokoto Goats

2021 ◽  
Vol 10 (1) ◽  
pp. 8-12
Keyword(s):  
Amniotic Fluid ◽  
Gestational Age ◽  
Total Protein ◽  
Biochemical Changes ◽  
Uterine Weight ◽  
Optimal Conditions ◽  
Crown Rump Length ◽  
Liver Markers ◽  
Twin Pregnancies ◽  
Fetal Fluids

Fetal fluids and placentas, which are important in feto-maternal homeostasis, could be affected by the number of developing fetuses. Therefore, placenta morphological and amniotic fluid biochemical changes associated with single and twin pregnancies in Red Sokoto goats were studied. Using Richardson’s formula, 2.1 × [CRL (cm) + 17], 12 intact gravid uteri (7 single-pregnant and 5 twin-pregnant) from mid-gestation [≈70-100 days gestational age (dGA)] pregnant goats were purposively selected. Feto-maternal biometrics [gravid uterine weight (GUW), total placental fluid volume (TPFV), average placentome diameter (APD), mean crown-rump length (MCRL), mean gestational age (MGA), mean fetal weight (MFW), total placentome number (TPN), and average interplacentomal distance (AID)]; amniotic fluid electrolytes [sodium (Na), potassium (K), chloride (Cl), calcium (Ca) and phosphorus (P)]; total protein; glucose; liver markers (AST and ALT); kidney markers (urea and creatinine), and cortisol concentrations were measured. The histology of the placentomes and the interplacentomal areas was also studied. The twin-pregnant (TP) goats had significantly higher (P<0.05) GUW, TPFV, APD, amniotic fluid glucose and cortisol; and lower (P<0.05) Ca levels. The rest of the parameters assessed did not differ between the TP and single-pregnant (SP) groups. Placentomes and the interplacentomal areas from the TP group had more diffuse villous inter-digitations and thicker luminal endothelium, respectively. It was concluded that TP Red Sokoto goats regulated placentome morphology, calcium, glucose and cortisol levels in order to achieve optimal conditions for the dams and the fetuses.

Detection of the Small-for-Gestational Age Twin Fetus by a Two-Stage Ultrasound Examination Schedule

1982 ◽  
Vol 31 (3-4) ◽  
pp. 235-240 ◽  
Author(s):  
J.P. Neilson
Keyword(s):  
Early Pregnancy ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Ultrasound Examination ◽  
Ultrasonic Measurement ◽  
Two Stage ◽  
Crown Rump Length ◽  
Biparietal Diameter ◽  
Ultrasonic Assessment ◽  
Twin Pregnancies

Serial ultrasonic measurement of the biparietal diameter is an unsatisfactory means of detecting the small-for-gestational age (SGA) fetus in twin pregnancies. A new two-stage ultrasound examination schedule, highly effective in detecting the SGA singleton fetus, has been evaluated prospectively in 31 twin pregnancies. The schedule comprises ultrasonic assessment of gestational age in early pregnancy, followed by measurement of the product of the crown–rump length and trunk area of both fetuses at 34–36 weeks. All Nineteen SGA twin fetuses were detected using this schedule; the technique offers several other advantages over serial biparietal cephalometry.

Gestational age-specific reference ranges for amniotic fluid assessment in monochorionic diamniotic twin pregnancies

2013 ◽  
Vol 41 (6) ◽  
pp. 649-652 ◽  
Author(s):  
P. DeKoninck ◽  
J. Deprest ◽  
P. Lewi ◽  
J. Richter ◽  
S. Galjaard ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Gestational Age ◽  
Specific Reference ◽  
Reference Ranges ◽  
Fluid Assessment ◽  
Twin Pregnancies

Association Between Twin Discordance at 6–9 Weeks' of Gestation and Birthweight Complications

2010 ◽  
Vol 13 (4) ◽  
pp. 389-392 ◽  
Author(s):  
Kirsten Palmer ◽  
Pavitra Delpachitra ◽  
Joseph Onwude ◽  
Luk Rombauts ◽  
Simon Meagher ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
First Trimester ◽  
In Vitro Fertilisation ◽  
Crown Rump Length ◽  
Increased Risk ◽  
Twin Pregnancies

AbstractTwins achieved through in-vitro fertilisation often undergo a viability ultrasound at 6–9 weeks of gestation. The presence of inter-twin crown-rump length discordance at this stage is not an uncommon finding; however the clinical significance of this is unknown. We analyzed 218 dichorionic twin pregnancies, producing two live fetuses > 24 weeks gestation, to determine whether inter-twin discordance (≥ 85th centile) in the mid-first trimester was associated with birthweight discordance (> 20%), or small for gestational age (< 10th centile). The incidence of birthweight discordance and small for gestational age infants were determined, with no increased risk found for the discordant population. This may provide some reassurance to treating clinicians.

Homocysteine levels in amniotic fluid

2006 ◽  
Vol 95 (04) ◽  
pp. 625-628 ◽  
Author(s):  
Donatella Colaizzo ◽  
Gennaro Vecchione ◽  
Natale Sciannamè ◽  
Angelo Notarangelo ◽  
Anna Croce ◽  
...  
Keyword(s):  
Birth Weight ◽  
Amniotic Fluid ◽  
Gestational Age ◽  
Univariate Analysis ◽  
Femur Length ◽  
Homocysteine Concentration ◽  
Biparietal Diameter ◽  
The Mean ◽  
Twin Pregnancies ◽  
Pregnancy And Birth

SummaryHyperhomocysteinemia could playa similar role in the placenta to that played in adults at risk of thrombosis. Moreover, hyperhomocysteinemia in women is described to be associated with the birth of small for gestational age (SGA) newborns, although there are discrepancies on this issue. To date, there is no biochemical marker predictive of SGA in a given pregnancy. We verified the presence of a relationship between homocysteine in amniotic fluid at mid-pregnancy and birth-weight. Amniotic fluid was obtained from 459 healthy women undergoing midtrimester amniocentesis (17.1 ± 1.2 weeks) because of maternal age. Homocysteine levels were measured in 434 (10 twin) pregnancies. In addition, femur length (FL) and biparietal diameter (BPD) were measured. Outcome of pregnancy was recorded. 233 (53.7%) foetuses were males,201 (46.3%) females. The mean homocysteine concentration was 1.04 ± 0.72 µM, (95% C.I. 0.43–2.41). An univariate analysis showed the presence of an association with gestational age, FL, BPD. A multiple linear regression showed that homocysteine levels were significantly associated with FL (p<0.001) and BPD (p=0.011). After excluding twin pregnancies, 31 newborns (7.3%) were classified as SGA. Mean birth-weight was 2390 g in SGA, where as it was 3360 g in 393 adequate for gestational age (AGA) newborns (p<0.001).The adjusted mean level of homocysteine was significantly lower in AGA (1.01 µM; 95%CI: 0.94–1.08) than that recorded in pregnancies resulting in a SGA (1.29 µM; 95%CI: 1.05–1.51; p=0.03). In a large setting, these data provide reference values for homocysteine in amniotic fluids. Moreover, they suggest that homocysteine levels in amniotic fluids may be higher in pregnancies with a SGA newborn.

scholarly journals Amniotic fluid optical density at spontaneous onset of labour and it’s correlation with gestational age, birth weight and functional maturity of newborn

2020 ◽  
Vol 9 (12) ◽  
pp. 5060
Author(s):  
Subha S. Sengodan ◽  
Santhya Velumani
Keyword(s):  
Birth Weight ◽  
Respiratory Distress ◽  
Amniotic Fluid ◽  
Optical Density ◽  
Gestational Age ◽  
Neonatal Morbidity ◽  
First Trimester ◽  
Simple Method ◽  
Crown Rump Length ◽  
Functional Maturity

Background: Respiratory distress is the common cause of neonatal morbidity and mortality. Babies born even at 40 weeks of gestation developed respiratory distress. The maturity of newborn is independent of gestational age and birth weight of newborn. In this study amniotic fluid optical density (AFOD) is correlated with the functional maturity of newborn.Methods: In this study, hundred singleton pregnant women who underwent first trimester scan and crown rump length estimation, and who were on spontaneous labor were selected for this observational study. Under aseptic precautions AF samples were collected while doing amniotomy with 2 ml disposable syringe, also collected during caesarean section after careful hysterotomy from the bulging membranes. Amniotic fluid optical density studied with spectrometer at 650 nm. Birth weights were recorded for all the babies. Babies are also looked for the respiratory distress, NICU admission.Results: In this study, respiratory distress was reported in 28% of newborns whereas 72% of newborns did not have distress. In the present study, 27% of newborns were admitted in NICU where as 73% of the newborns were on mother’s side following delivery. Babies with AFOD 0.98±0.27 were functionally mature, skin was pleased brown in colour with little vernix, none of them had respiratory distress. Amniotic fluid optical density <0.4 developed respiratory distress.Conclusions: Amniotic fluid optical density is a simple method to assess the functional maturity of newborn.

Sonographic Assessment of Amniotic Fluid Volume using Single Deepest Pocket (SDP) among Igbo Women with Uncomplicated Singleton Pregnancies.

2019 ◽  
Vol 2 (1) ◽  
pp. 1-18
Author(s):  
Chijioke Okeudo ◽  
B.U. Ezem
Keyword(s):  
Amniotic Fluid ◽  
Gestational Age ◽  
Cross Sectional Study ◽  
Fluid Volume ◽  
Singleton Pregnancy ◽  
Cross Sectional ◽  
South Eastern ◽  
Amniotic Fluid Volume ◽  
The Mean ◽  
Singleton Pregnancies

Background: The amniotic fluid is fundamental for proper fetal development and growth. Ultrasound visualization of the amniotic fluid permits both subjective and objective estimates of the amniotic fluid. Objective: The objective of this study was to determine the reference values of normal single deepest pocket (SDP) – upper and lower limits, mean SDP and variation of the SDP with gestational age among Igbo women of South-Eastern Nigeria extraction carrying uncomplicated singleton pregnancy. Methodology: This was a prospective cross sectional study involving 400 women carrying uncomplicated singleton pregnancies and who were sure of the date of the first day of their last menstrual period. The single deepest pocket / maximum vertical pool were determined once at presentation at the hospital.. The study was conducted from January 1st to December 31st 2015. The second author carried out all the scanning. The SDP was obtained. Results: The womens’ mean and median ages were the same at 28 years. The gestational age range of the pregnancies was 14-41 weeks. The mean SDP was 5.8cm, while the 5th and 95th percentiles were 3.3cm and 8.5cm respectively. There was no difference in the mean SDP in both term and preterm. There was irregular but continuous rise of mean SDP to a peak of 6.8cm at gestational age of 39 weeks. In conclusion, the participants had a mean SDP of 5.8cm. There was also a positive correlation between SDP and Gestational age. We therefore recommend a longitudinal study to assess perinatal outcome and abnormal amniotic fluid volume among Igbo women of South-Eastern Nigeria. Key words: Single Deepest Pocket, Uncomplicated Singleton Pregnancy, Igbo Women.

Is there a Need for Own Median Calculation in the Second Trimester Biochemical Markers Screening?

2017 ◽  
Vol 68 (5) ◽  
pp. 1070-1072
Author(s):  
Dan Navolan ◽  
Mirela Nicolov ◽  
Simona Vladareanu ◽  
Ioana Ciohat ◽  
Marius Craina ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Biochemical Markers ◽  
Biochemical Marker ◽  
Second Trimester ◽  
Established Method ◽  
Crown Rump Length ◽  
The Difference ◽  
Fetal Aneuploidies ◽  
Singleton Pregnancies

Screening of fetal aneuploidies in early pregnancy is a well-established method in the materno-fetal medicine. The aim of our study was to analyze if the medians recommended by the manufacturers are adequate to perform an accurate screening or if there is a need for own laboratory medians calculation in second trimester biochemical marker screening.Sera were collected between 14 wp and 22 wp from 3374 singleton pregnancies. We analyzed three second trimester biochemical markers (AFP, hCG and free Estriol) concentration in all pregnant women and in a subgroup of pregnant women in which gestational age was determined based on crown-rump length. Our results showed that for all biochemical markers the difference between the manufacturer and the own calculated median was lower than 10% excepting the hCG value in the group of pregnant women in which the gestational age was determined on basis of crown-rump-length. Our results show it is recommended to replace the values of the median for hCG measurement with the own laboratory calculated medians. This does not seem to be necessary in the case of AFP and free Estriol measurement.

scholarly journals Locked twins—remote from term: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Abraham Fessehaye ◽  
Ferid A. Abubeker ◽  
Mekdes Daba
Keyword(s):  
Gestational Age ◽  
Twin Pregnancy ◽  
Caesarian Section ◽  
Obstetric Complication ◽  
Second Stage ◽  
Case Summary ◽  
History Of ◽  
Twin Pregnancies ◽  
Abdominal Delivery ◽  
First Stage Of Labor

Abstract Background Locked twins is a rare and hazardous obstetric complication, which occurs in approximately 1:100 twin pregnancies. One of the known etiologic factors for locked twins is size of the twins. We report a case of chin-to-chin locked twins that occurred at gestational age of 30 weeks pus 6 days. Case summary A 27 years-old primigravida Oromo mother presented with a history of pushing down pain and passage of liquor of 6 hours duration at gestational age of 30 weeks plus 6 days. With a diagnosis of twin pregnancy (first twin non-vertex), abdominal delivery was decided in latent first stage of labor but mother refused caesarian delivery and she was allowed to labor with the hope of achieving a vaginal delivery. In second stage, interlocking twin was encountered and a low vertical cesarean section was done to effect delivery of twins without the need to decapitate the first twin. Conclusion Locked twin is a rare obstetric complication. Whenever it is encountered, successful delivery can be achieved without the need to have decapitation of the first twin during caesarian section.

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