Modal Frequencies Associations with Musculoskeletal Components of Human Legs for Extracorporeal Bone Healing Assessment Based on a Vibration Analysis Approach

Reliable and quantitative assessments of bone quality and fracture healing prompt well-optimised patient healthcare management and earlier surgical intervention prior to complications of nonunion and malunion. This study presents a clinical investigation on modal frequencies associations with musculoskeletal components of human legs by using a prototype device based on a vibration analysis method. The findings indicated that the first out-of-plane and coupled modes in the frequency range from 60 to 110 Hz are associated with the femur length, suggesting these modes are suitable quantitative measures for bone evaluation. Furthermore, higher-order modes are shown to be associated with the muscle and fat mass of the leg. In addition, mathematical models are formulated via a stepwise regression approach to determine the modal frequencies using the measured leg components as variables. The optimal models of the first modes consist of only femur length as the independent variable and explain approximately 43% of the variation of the modal frequencies. The subsequent findings provide insights for further development on utilising vibration-based methods for practical bone and fracture healing monitoring.

Keragaman Fenotipe Kualitatif dan Kuantitatif Itik Sikumbang Jonti sebagai Plasma Nutfah di Sumatera Barat

This research was aimed to identifiaty qualitative and quantitative phenotypic polymorphism of Sikumbang Jonti Duck in Kecamatan Payakumbuh Timur Kota Payakumbuh Sumatera Barat. This research used 206 Sikumbang Jonti duck that were sexual maturity (22-48 weeks), divided of 50 males and 156 females. The qualitative traits observeted were head color, neck color, breaks color, back color, primary wings color, tail color, thigh color, bill color, and shank color. The quantitative traits observed were body weight (kg), beak width (cm), beak length (cm), neck length (cm), wing length (cm), femur length (cm), tibia length (cm), shank length (cm), back length (cm), number of primary wing feathers (strands), number of secondary wing feathers (strands), pelvic width (cm), and chest circumference (cm). The result showed that color of Sikumbang Jonti duck was dominated by white. Male Sikumbang Jonti duck had color head was white-black, and female had color head was white. In addition, the Sikumbang Jonti duck had green primary wing feathers like a beetle. The coefficient of diversity of the Sikumbang Jonti duck was low for beak width, tibia length (female), number of primary wing feathers, and number of secondary wing feathers, moderate value for body weight, beak length, neck length, wing length, femur length (female), length tibia (male), shank length, back length, perlvis width (females), and chest circumference (males), and high value for femur length (males). Keywords: Duck morphometric; Germplasm; Pattern color; Payakumbuh; Sumatera barat Abstrak Penelitian ini bertujuan untuk mengindentifikasi keragaman fenotipe kualitatif dan kuantitatif itik Sikumbang Jonti di Kecamatan Payakumbuh Timur Kota Payakumbuh Provinsi Sumatera Barat. Penelitian ini menggunakan 206 ekor itik Sikumbang Jonti yang sudah dewasa kelamin (22 – 48 minggu), terdiri dari 50 ekor jantan dan 156 ekor betina. Sifat kualitatif yang diamati adalah warna bulu head, warna bulu neck, warna bulu breaks, warna back, warna primary wings, warna tail, warna thigh, warna bill, dan warna shank. Sifat kuantitatif yang diamati adalah bobot badan (kg), lebar paruh (cm), panjang paruh (cm), panjang leher (cm), panjang sayap (cm), panjang femur (cm), panjang tibia (cm), panjang shank (cm), panjang punggung (cm), jumlah bulu sayap primer (helai), jumlah bulu sayap sekunder(helai), lebar pelvis (cm), dan lingkar dada (cm). Hasil menunjukkan warna bulu itik Sikumbang Jonti didominasi dengan warna bulu putih. Warna bulu kepala itik Sikumbang Jonti jantan berwarna putih-hitam, sedangkan itik Sikumbang Jonti betina berwarna putih. Selain itu, itik Sikumbang Jonti memiliki warna bulu sayap primer berwarna hijau seperti kumbang. Koefisien keragaman itik Sikumbang Jonti bernilai rendah untuk lebar paruh, panjang tibia (betina), jumlah bulu sayap primer, dan jumlah bulu sayap sekunder, bernilai sedang untuk bobot badan, panjang paruh, panjang leher, panjang sayap, panajng femur (betina), panjang tibia (jantan), panjang shank, panjang punggung, lebar perlvis (betina), dan lingkar dada (jantan), dan bernilai tinggi untuk panjang femur (jantan). Keragaman fenotipe kualitatif dan kuantitatif pada itik Sikumbang Jonti relatif seragam, kecuali pada fenotipe kuantitatif panjang femur pada itik Sikumbang Jonti jantan memiliki keragaman tinggi. Kata kunci: Morfometrik itik; Payakumbuh; Plasma nutfah; Sumatera barat; Warna bulu

Evaluation of biparietal diameter and femur length by ultrasonography method, its correlation with fetal gestational age a comparative study in Chhattisgarh state of India

There few studies which tried to corelate biparietal diameter and gestational age in which an increase in biparietal diameter with the increase in gestational age was found but there was a discrepancy between 17 week of pregnancy and term and which is approximately 3 weeks. We conducted the present study to compare the gestational age and femur length and biparietal diameter in the population of Chhattisgarh state of India.A total of 380 pregnant females were enrolled for the study. They were between the 20 weeks to 38 weeks of gestation with their age ranging from 18-35 years.In the present study we observed a total of 158 cases in 2 trimester i.e. ranging from 20 to 27 weeks and 220 cases were in 3 trimester of pregnancy. Mean of BPD and FL observed was 73.1 and 56.2 respectively. The standard deviation and standard error of mean for biparietal diameter and femur length were 12.8, 11.6 and 0.63, 0.57 respectively.All parameters of present study are found to be highly correlated with gestational age. (r=, 0.987, 0.980 for, FL and BPD respectively).

Associations of Longitudinal Fetal Growth Patterns With Cardiometabolic Factors at Birth

BackgroundBirth weight is associated with cardiometabolic factors at birth. However, it is unclear when these associations occur in fetal life. We aimed to investigate the associations between fetal growth in different gestational periods and cord blood cardiometabolic factors.MethodsWe included 1,458 newborns from the Born in Guangzhou Cohort Study, China. Z-scores of fetal size parameters [weight, abdominal circumference (AC), and femur length (FL)] at 22 weeks and growth at 22–27, 28–36, and ≥37 weeks were calculated from multilevel linear spline models. Multiple linear regression was used to examine the associations between fetal growth variables and z-scores of cord blood cardiometabolic factors.ResultsFetal weight at each period was positively associated with insulin levels, with stronger association at 28–36 weeks (β, 0.31; 95% CI, 0.23 to 0.39) and ≥37 weeks (β, 0.15; 95% CI, 0.10 to 0.20) compared with earlier gestational periods. Fetal weight at 28–36 (β, −0.32; 95% CI, −0.39 to −0.24) and ≥37 weeks (β, −0.26; 95% CI, −0.31 to −0.21) was negatively associated with triglyceride levels, whereas weight at 28–36 weeks was positively associated with HDL levels (β, 0.12; 95% CI, 0.04 to 0.20). Similar results were observed for AC. Fetal FL at 22 and 22–27 weeks was associated with increased levels of insulin, glucose, and HDL.ConclusionsFetal growth at different gestational periods was associated with cardiometabolic factors at birth, suggesting that an interplay between fetal growth and cardiometabolic factors might exist early in pregnancy.

Impact of Placenta Previa on Fetal Growth

Background: Placenta Previa refers to the presence of placental tissue that extends over the internal cervical is during pregnancy. The incidence of this condition is reported to be 2% at 20 weeks of gestation and decreases to around 4–6 per 1000 births between 34 and 39 weeks through trophotropism. The aim of the work is to evaluate fetal growth in pregnancies complicated by placenta Previa. Methods: This cross-sectional study was done on 100 pregnant females with placenta Previa aged 18-35 years. Cases were defined as patients with gestational age 24-40 weeks, BMI 18-30 kg/m2, Singleton fetus and diagnosed having placenta Previa; confirmed by trans-vaginal ultrasound in the second and third trimester. Complete history, vital signs and complete obstetric examination, laboratory and radiological investigations (ultrasound done trans-abdominally to evaluate fetal weight, biometry and Doppler studies) were taken. Results: The gestational age ranged from 34-39 weeks with a mean value 36.03 ± 1.23 weeks and a median value 36 weeks (IQR = 35-37 weeks). The femur length ranged from 33.14-39.14 weeks with a mean value 35.44 ± 1.56 weeks and a median value 35.14 weeks (IQR = 34-36.9 weeks).The abdominal circumference ranged from 32.86-39.14 weeks with a mean value 35.43 ± 1.65 weeks with a median value 35.14 weeks (IQR = 33.9-36.7 weeks). As regard to umbilical (UA) and middle cerebral (MCA) arteries Doppler resistant index (RI), UA ranged from 0.48-0.58 with a mean value 0.53 ± 0.03 and a median value 0.53 (IQR = 0.51-0.55). MCA ranged from 0.75-0.85 with a mean value 0.80 ± 0.03 and a median value 0.79 (IQR = 0.77-0.82). Conclusion: Placenta Previa led to preterm delivery (<36 weeks) in about one third of the study cases. Femur length was <36 weeks in 65 patients. Abdominal circumference was <36 weeks in 61 patients. Placenta Previa had insignificant effect on umbilical (UA) and middle cerebral arteries Doppler resistant index.

Is Cardiomegaly an Indication of “Heart-Sparing Effect” in Small Fetuses?

<b><i>Introduction:</i></b> This study aimed to test the hypothesis that cardiac size is maintained in small fetuses presenting with cardiomegaly. <b><i>Materials and Methods:</i></b> We identified singleton fetuses with estimated fetal weight &#x3c;10th centile and with cardiomegaly without another more likely cardiac or extra-cardiac cause. We used <i>Z</i>-scores for cardiac and thoracic circumferences normalized for gestational age (GA), biparietal diameter (BPD), head circumference (HC), and femur length (FL), obtained from 188 normally grown fetuses. <b><i>Results:</i></b> When comparing chest size, small fetuses had significantly lower thoracic circumferences median <i>Z</i>-scores (IQR) for GA = −4.82 (−6.15 to −3.51), BPD = −2.42 (−4.04 to −1.48), HC = −2.72 (−4.53 to −1.90), and FL = −1.60 (−2.87 to −0.71); <i>p</i> &#x3c; 0.001 for all. When comparing heart size, small fetuses showed lower cardiac circumferences median <i>Z</i>-scores (IQR) for GA = −1.59 (−2.79 to −0.16); <i>p</i> &#x3c; 0.001, similar cardiac circumferences <i>Z</i>-scores for BPD = 0.29 (−0.65 to 1.28); <i>p</i> = 0.284 and HC = 0.11 (−1.13 to 0.96); <i>p</i> = 0.953, and higher cardiac circumferences <i>Z</i>-scores for FL = 0.94 (−0.05 to 2.13); <i>p</i> &#x3c; 0.001. <b><i>Conclusions:</i></b> Our results show that in small fetuses with cardiomegaly, the heart maintains normal dimensions when normalized to cranial diameters and higher dimensions when normalized to long bones. This provides insight into cardiac adaptation to adverse intrauterine environment.

Derivation of regression equation for estimation of stature by using measurement of femur

Background: Reconstruction of stature from broken fragments of bones is used as a part of the analysis in forensic anthropology for the purpose of identification of an individual. Long bones are traditionally used for estimation of stature. Long bones such as femur and tibia are the most important components of an individual’s stature. In the present study, regression equation was derived for estimation of maximum femoral length from measurements of the proximal end of femur. Aims and Objectives: To derive regression equations using femur length from measurements of neck-shaft angle and maximum vertical diameter of femur head. Materials and Methods: Two hundred unpaired femurs, devoid of gross pathology and irrespective of gender obtained from the Department of Anatomy of both VMKVMC &VMHMC were used for this study. The correlation coefficients of the neck-shaft angle and maximum diameter of head of femur to the maximum length of femur was calculated. These co-efficient were used for formulation of regression equation. Results: The present study was done to show that the maximum length of femur can be best calculated from the metric evaluation of vertical diameter of the head when the proximal fragments are available. The parameters in our study which includes maximum vertical diameter of the head showed positive correlation but the neck- shaft angle showed a low correlation and is not reliable to measure MFL from it. Conclusion: The present study concludes that the maximum length of femur can be best calculated from the metric evaluation of vertical diameter of the head when the proximal fragments are available.

Comparison Between Fetal Biometric Measurements (BPD, HC and FL) of Male and Female Fetuses in Population of Pakistan on Antenatal Ultrasound, A Multicentric Study

Objective: The aim of this study was to compare the fetal biometric growth measurements (Head Circumference, Bi-Parietal Diameter, and Femur Length) between male and female fetuses on antenatal ultrasound in our population. Methodology: This was an observational study carried out in the Department of Radiology CMH Malir, Karachi and Ziauddin hospital, Karachi from July 2016 till July 2018 using non-probability sampling technique. A total of 510 pregnant women with second and third trimester were enrolled for the study. The biometric parameters of fetus i.e., Bi-Parietal Diameter, Head Circumference, and Femur Length were established through two-dimensional ultrasound. Chi-square and t tests were used to analyze differences in biometric parameters in both genders. Results: The study results showed significant differences in the Bi-Parietal Diameter and Head Circumference between male and female fetuses (p=0.006 and p=0.003, respectively). Mean Bi-Parietal Diameter in males was 71.47±13.70 and in females it was68.30±11.90cm, mean Head Circumference in males was 264.23±47.87and in females it was 252.03±44.91cm. It has also been observed that there was an insignificant difference in the femur length between male and female fetuses (p= 0.605). Mean femur length was 52.74±12.39 in males and 52.19±11.38 in females. Conclusion: This study concluded that male fetuses have considerably larger bi-parietal diameter and head circumference as compared to female fetuses however, no variation in femur length is observed in both genders. Keywords: Fetal Gender, Bi-Parietal Diameter, Head Circumference, Femur Length.