scholarly journals Selected Landmark Studies in the Role of the Mesolimbic System

Author(s):  
Prakul Suresh ◽  
◽  
Karan Patel ◽  

The mesolimbic system has been demonstrated to have a major role in the perception of pain, but the mechanisms by which this occurs are poorly understood. In this paper, we review selected landmark studies that have contributed to our present understanding of the role of the mesolimbic system. The included studies outline the molecular mechanisms of the mesolimbic system's role in analgesia, pain relief, and feelings of decreased motivation and depression as a result of chronic pain. Because chronic pain is among the most highly-cited reasons for decreased quality of life, advancing our understanding of the function and mechanism of the mesolimbic system may be critical to improving the quality of life for millions of people around the globe.

Author(s):  
Prakul Suresh ◽  
◽  
Basil M Baccouche ◽  

The mesolimbic system has been demonstrated to have a major role in the perception of pain, but the mechanisms by which this occurs are poorly understood. In this paper, we review selected landmark studies that have contributed to our present understanding of the role of the mesolimbic system. The included studies outline the molecular mechanisms of the mesolimbic system's role in analgesia, pain relief, and feelings of decreased motivation and depression as a result of chronic pain. Because chronic pain is among the most highly-cited reasons for decreased quality of life, advancing our understanding of the function and mechanism of the mesolimbic system may be critical to improving the quality of life for millions of people around the globe


2007 ◽  
Author(s):  
Jeffrey I. Gold ◽  
Trina Haselrig ◽  
D. Colette Nicolaou ◽  
Katharine A. Belmont

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jingyao Cai ◽  
Min Hu ◽  
Zhiyang Chen ◽  
Zeng Ling

AbstractLiver fibrosis occurs in response to any etiology of chronic liver injury. Lack of appropriate clinical intervention will lead to liver cirrhosis or hepatocellular carcinoma (HCC), seriously affecting the quality of life of patients, but the current clinical treatments of liver fibrosis have not been developed yet. Recent studies have shown that hypoxia is a key factor promoting the progression of liver fibrosis. Hypoxia can cause liver fibrosis. Liver fibrosis can, in turn, profoundly further deepen the degree of hypoxia. Therefore, exploring the role of hypoxia in liver fibrosis will help to further understand the process of liver fibrosis, and provide the theoretical basis for its diagnosis and treatment, which is of great significance to avoid further deterioration of liver diseases and protect the life and health of patients. This review highlights the recent advances in cellular and molecular mechanisms of hypoxia in developments of liver fibrosis.


2017 ◽  
Vol 49 (6) ◽  
pp. 489-496 ◽  
Author(s):  
R Müller ◽  
G Landmann ◽  
M Béchir ◽  
T Hinrichs ◽  
U Arnet ◽  
...  

Reumatismo ◽  
2012 ◽  
Vol 64 (3) ◽  
Author(s):  
M. Capraro ◽  
M. Della Valle ◽  
M. Podswiadek ◽  
P. De Sandre ◽  
E. Sgnaolin ◽  
...  

2006 ◽  
Vol 24 (2) ◽  
pp. 80-86 ◽  
Author(s):  
Silje Teig ◽  
Sue Peacock ◽  
Lorraine Stevens ◽  
Kimberley Tordoff ◽  
Edwina Maguire ◽  
...  

Background Acupuncture is increasingly offered as a treatment for chronic pain, but continued treatment is expensive. Self acupuncture might offer a cost effective alternative. The aim of this project was to investigate the effectiveness and safety of self acupuncture in a pain clinic. Methods A retrospective audit was conducted by postal questionnaire of all patients with chronic pain who were taught self acupuncture as a home pain management strategy in the previous three years. The study was conducted by a researcher not involved in the patient's treatment. The patients selected for self acupuncture were those who had responded to acupuncture previously, met certain criteria, and had been taught self acupuncture successfully. Patients were taught self acupuncture using three acupuncture points (LI4, ST44, LR3). Results Of 52 eligible patients (70% female) who were approached, 38 valid questionnaires were returned, giving a response rate of 73.1%. Of these, 76.3% were female; 86.8% (33) still used self acupuncture and 13.3% (5) had stopped; 86.8% of the patients continued to experience pain reduction with self acupuncture. The reported pain relief gained was 5.7 (SD 2.6) measured on a visual analogue scale, improvement in quality of life was reported by 73.7% and no serious adverse effects were reported. Conclusion This audit suggests that self acupuncture is effective for pain relief and improves quality of life in this selected group of patients. Safety can be maintained provided that pre-selection is done with care, and appropriate training is carried out. Self acupuncture has considerable potential to reduce clinic waiting lists and appointment times for patients. Further research is required to determine the cost effectiveness of this approach.


Pain Medicine ◽  
2017 ◽  
Vol 19 (7) ◽  
pp. 1304-1314 ◽  
Author(s):  
Luz Cánovas ◽  
Antonio-José Carrascosa ◽  
Modesto García ◽  
Mariano Fernández ◽  
Almudena Calvo ◽  
...  

Epigenomics ◽  
2021 ◽  
Author(s):  
Farbod Bahreini ◽  
Parnian Jabbari ◽  
Wilhelm Gossing ◽  
Fatemeh Aziziyan ◽  
Marcus Frohme ◽  
...  

Pituitary adenomas (PAs) are common cranial tumors that affect the quality of life in patients. Early detection of PA is beneficial for avoiding clinical complications of this disease and increasing the quality of life. Noncoding RNAs, including long noncoding RNA, miRNA and circRNA, regulate protein expression, mostly by inhibiting the translation process. Studies have shown that dysregulation of noncoding RNAs is associated with PA. Hence understanding the expression pattern of noncoding RNAs can be considered a promising method for developing biomarkers. This article reviews data on the expression pattern of dysregulated noncoding RNAs involved in PA. Possible molecular mechanisms by which the dysregulated noncoding RNA could possibly induce PA are also described.


2018 ◽  
Vol 8 (3) ◽  
pp. 34-42
Author(s):  
N. V. Latysheva ◽  
E. G. Filatova ◽  
D. V. Osipova

Over a half of chronic pain (CP) patients present with cognitive complaints, which increase their disability and impact quality of life. The paper reviews objective impairments in memory, attention, processing speed and executive function demonstrated in the CP population. The paper also reviews common pathology underlying cognitive impairment and CP: neuroplasticity in the shared brain areas, neurotransmitter and other molecular mechanisms. Common mechanisms in CP and depression precipitating cognitive impairment are also discussed. The paper also compares the potential of different antidepressants to improve cognitive functions in depression and CP.


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