scholarly journals FNAC: A Simple & Cost-Effective Diagnostic Tool for Benign & Malignant Pathologies Associated with Cervical Lymphadenopathy

2021 ◽  
Vol 35 (4) ◽  
pp. 25-29
Author(s):  
Sohail Anwar
Keyword(s):  
Diagnostic Tool ◽  
Cervical Lymphadenopathy ◽  
Cost Effective ◽  
Needle Aspiration ◽  
P Value ◽  
Invasive Test ◽  
Outpatient Departments ◽  
Metastatic Neoplasm ◽  
Needle Aspiration Cytology ◽  
Age Range

Introduction: Cervical lymphadenopathy is very common as the presenting complaint in our outpatient departments. Its etiology may either be benign or malignant. Fine needle aspiration cytology (FNAC) is a comparatively cheap, easy to perform minimally invasive test. It has become the go to test to determine the cause of lymphadenopathy Aims & Objectives: To determine whether FNAC is a cost-effective diagnostic tool in evaluation of various benign and malignant Pathologies associated with cervical lymphadenopathy. Place and duration of study: It is a retrospective study conducted at Gulab Devi Hospital from April 2019 to April 2021. Material & Methods: The cyto-morphologic features seen in the aspirates were critically analyzed and correlated with their etiology. SPSS version 24.0 was analyzed for data analysis. A p-value of <0.05 was considered significant. Results: Among the 100 patients 56 were females and 44 were males with a female to male ratio of 1.3:1. The age range of the patients was from 3 to 75 years. 37% were reactive lymphadenitis, 32% were tuberculosis, 12% were suppurative, 11% were lymphoproliferative disorders, 8% cases were metastatic neoplasm. Conclusion: FNAC is a reliable and cost effective to diagnose the etiologies of cervical lymphadenopathy.

scholarly journals Fine needle cytology-diagnostic tool for palpable orbital and eyelid lesions

2017 ◽  
Vol 5 (6) ◽  
pp. 2592 ◽  
Author(s):  
Nupur Rastogi ◽  
A. Gupta ◽  
A. Gupta
Keyword(s):  
Diagnostic Tool ◽  
Histopathological Examination ◽  
Age Groups ◽  
Ct Scanning ◽  
Cost Effective ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Cost Effective Method ◽  
Needle Aspiration Cytology ◽  
Eyelid Lesions

Background: Fine needle aspiration cytology in orbital lesions gained importance in the last 3 decades. FNAC can be used for aiding the clinician to plan treatment of orbital and eyelid tumors study was undertaken to evaluate the role of FNAC as a diagnostic tool for diagnosis and management of various orbital and eyelid lesions, as it is of great value in the diagnosis of new primary, recurrent and metastatic orbital tumors.Methods: Patients of different age groups presenting with orbital and eyelid lesions were studied over a period of 4 years from March 2013 to Feb 2017. The 75 patients selected for this study were clinically evaluated and then investigated with computed tomograpghy (CT) scanning. Each patient was subjected to FNAC under direct vision/ultrasongraphy guidance with sterile 22 guage needle without anaesthesia. Biopsy was done to confirm the cytological diagnosis.Results: The age of patients varied from 3 years to 70 years. On cytology 61 cases were benign and 14 malignant. Histopathological examination of 53 cases was done which confirmed the cytological diagnosis.Conclusions: FNAC is a useful, rapid, safe and cost effective method for diagnosing orbital and eyelid pathology.

scholarly journals ROSE in Rosai–Dorfman–Destombes (RDD) disease: a cytological diagnosis

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Santosh Tummidi ◽  
Hemant Kumar Singh ◽  
Prudhvinath A Reddy ◽  
Manda Sindhura ◽  
Navya Kosaraju ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Cervical Lymphadenopathy ◽  
Cost Effective ◽  
Needle Aspiration ◽  
Cervical Lymph Nodes ◽  
Massive Lymphadenopathy ◽  
Cost Effective Method ◽  
Site Evaluation ◽  
Cytological Features ◽  
Needle Aspiration Cytology

Abstract Background Rosai–Dorfman–Destombes (RDD) is also known as sinus histiocytosis with massive lymphadenopathy (SHML). It is a benign proliferative disorder of histiocytes, affecting lymph nodes, rarely with extra-nodal involvement. Rapid on-site evaluation (ROSE) with fine-needle aspiration cytology (FNAC) can be utilized as a minimally invasive investigation to avoid unnecessary surgery of this self-limiting disease. Case presentation A 65-year-old female presented with complaints of bilateral cervical lymphadenopathy since 1 year. Rapid on-site stain with FNAC from bilateral cervical lymph nodes revealed features of Rosai–Dorfman–Destombes (RDD) disease. Conclusion FNAC with rapid on-site evaluation can provide a simple and cost-effective method for looking at the unique cytological features of the disease and act as a first-line investigation.

scholarly journals Predictive Evaluation on Cytological Sample of Metastatic Melanoma: The Role of BRAF Immunocytochemistry in the Molecular Era

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1110
Author(s):  
Andrea Ronchi ◽  
Marco Montella ◽  
Federica Zito Marino ◽  
Michele Caraglia ◽  
Anna Grimaldi ◽  
...  
Keyword(s):  
Metastatic Melanoma ◽  
Molecular Analysis ◽  
Predictive Value ◽  
Diagnostic Performance ◽  
Cost Effective ◽  
Needle Aspiration ◽  
Braf V600e ◽  
Mutational Status ◽  
Needle Aspiration Cytology ◽  
Sensitivity Specificity

Background: Cutaneous malignant melanoma is an aggressive neoplasm. In advanced cases, the therapeutic choice depends on the mutational status of BRAF. Fine needle aspiration cytology (FNA) is often applied to the management of patients affected by melanoma, mainly for the diagnosis of metastases. The evaluation of BRAF mutational status by sequencing technique on cytological samples may be inconvenient, as it is a time and biomaterial-consuming technique. Recently, BRAF immunocytochemistry (ICC) was applied for the evaluation of BRAF V600E mutational status. Although it may be useful mainly in cytological samples, data about BRAF ICC on cytological samples are missing. Methods: We performed BRAF ICC on a series of 50 FNA samples of metastatic melanoma. BRAF molecular analysis was performed on the same cytological samples or on the corresponding histological samples. Molecular analysis was considered the gold standard. Results: BRAF ICC results were adequate in 49 out of 50 (98%) cases, positive in 15 out of 50 (30%) cases and negative in 34 out of 50 (68%) of cases. Overall, BRAF ICC sensitivity, specificity, positive predictive value and negative predictive value results were 88.2%, 100%, 100% and 94.1%, respectively. The diagnostic performance of BRAF ICC results was perfect when molecular evaluation was performed on the same cytological samples. Hyperpigmentation represents the main limitation of the technique. Conclusions: BRAF ICC is a rapid, cost-effective method for detecting BRAF V600E mutation in melanoma metastases, applicable with high diagnostic performance to cytological samples. It could represent the first step to evaluate BRAF mutational status in cytological samples, mainly in poorly cellular cases.

scholarly journals Clinicopathological features of pilomatricoma cases: Analysis of 21 cases

2014 ◽  
Vol 4 (7) ◽  
pp. 530-533
Author(s):  
D Ghartimagar ◽  
A Ghosh ◽  
K Gautam ◽  
S Thapa ◽  
SR Shrestha ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Needle Aspiration ◽  
Common Finding ◽  
Clinical Impression ◽  
Aspiration Cytology ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Needle Aspiration Cytology ◽  
Age Range ◽  
Slow Growing

Background: Pilomatricoma is a slow-growing, asymptomatic tumour originating from outer sheath cells of hair follicle. In this study, we describe the clinical presentation and histopathological features of pilomatricoma. Materials and Methods: This was a hospital based retrospective study carried out in all patients who were diagnosed as pilomatricoma over a period of January 2001 to December 2013. The study was done in department of pathology, Manipal Teaching Hospital, Nepal. Results: A total of 21 cases of pilomatricoma were reported with age range of 9-53 years (mean age 23.7) and male female ratio of 1:1.1. The most common site of occurrence was neck and preauricular region. The size of the tumour ranged from 0.3 to 4.7cm with a mean of 1.2cm. Multiple occurrences were seen in 3 patients and ossifying pilomarticoma was seen in 4 cases. Conclusion: Pilomatricoma is a benign skin neoplasm of hair follicle matrix cells. Calcification is a common finding while dystrophic ossification also can occur in the tumour. Histopathology gives the definite diagnosis as fine needle aspiration cytology and clinical impression may be misleading. DOI: http://dx.doi.org/10.3126/jpn.v4i7.10293 Journal of Pathology of Nepal (2014) Vol. 4, 530-533

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