Abhava pratinidhi dravya:  A Comparative Phytochemical Study of Bharangi and Kantakari

Abhava pratinidhi dravya excites the scientific curiosity concerning the Ayurvedic principles behind selection of the substitute drug. Present study had reported a comparative phytochemical study of one such Ayurvedic substitution pair: Solanum surattense Burm.f., a substitute for Clerodendrum serratum L. The study was conducted to understand the logic behind the Abhava pratinidhi dravya (Drug substitution). The strategy was to scrutinize and compare their Ayurvedic properties by literary studies and test the phytochemical profile of these two herbs for biochemical similiarties and differences. On analyzing their Ayurvedic pharmacology (Dravyaguna properties), findings show that both the drugs possess katu and tikta rasa, but Bharangi is katu rasa dominant and Kantakari is tikta rasa dominant drug. Along with this, both drug possess laghu, ruksha and ushna guna in common. Kantakari which contain different properties i.e. sara and tikshna guna. Both drug possess katu vipaka and ushna veerya. Both drugs had been stated to treat majority of respiratory ailments. Phytochemical observations suggest that in Bharangi root extract alkaloids and tannins was present whereas Kantakari root extract was rich in flavonoids content. Saponins was present in maximum amount in both the plant extracts. Despite taxonomically unrelated and morphologically dissimiliar, Bharangi has been substituted by Kantakari drug. In Ayurveda, more importance was given to pharmacological properties of raw drug rather than its botanical classification. Further comparative pre-clinical studies and bio-equivalence clinical studies has been needed to explore the different pharmacological properties.

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Determination and Selection of the Optimum Number of Sites and Patients for Clinical Studies

Journal of Dental Research ◽

10.1177/00220345920710081001 ◽

1992 ◽

Vol 71 (8) ◽

pp. 1516-1521 ◽

Cited By ~ 6

Author(s):

P.P. Hujoel ◽

T.A. DeRouen

Keyword(s):

Clinical Studies ◽

Optimum Number ◽

Selection Of

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An Investigation on the Properties of Zingiber officinale Rose and Its Application in Nutrition and Medicine Based on Scientific and Islamic Texts

Tabari Biomedical Student Research Journal ◽

10.18502/tbsrj.v3i4.7791 ◽

2021 ◽

Author(s):

Hamed Fathi ◽

Fatemeh Faraji ◽

Niusha Esmaealzadeh ◽

Shahram Eslami ◽

Mohammad Bagher Mohammadi Laeeni

Keyword(s):

Clinical Studies ◽

Web Of Science ◽

Zingiber Officinale ◽

Modern Medicine ◽

Pharmacological Properties ◽

Laboratory Studies ◽

Scientific Databases ◽

Positive Effects ◽

Persian Medicine ◽

Traditional Persian Medicine

Introduction: Zingiber officinale Rose (ginger) has been used for many purposes in traditional medicine since 2500 years ago. This study intends to introduce the ginger plant, some of their applications in the field of human health in traditional and modern medicine, and their conformity with Islamic and Quranic findings. Material and Methods: Administrative and therapeutic information of ginger plant has been searched in related and valid books, scientific databases including Web of Science, PubMed, SID, Google Scholar, and Scopus. Ginger keyword has been searched in the Quran and hadiths and its medicinal and pharmacological properties; also in traditional Persian medicine and laboratory studies, the day, was collected from published articles. In order to confirm the obtained information, it was matched with Quranic and narration versions, and the obtained information was analyzed, compiled, and presented. Results: Avicenna has mentioned the positive effects of ginger in his Canon of Medicine. The Food and Drug Administration of the Ministry of Health in Iran has also introduced ginger as a dietary supplement. Ginger is one of those plants which name is mentioned in the Quran, in verse 17 of Surah Al-Insan. In narrations and quoting scientists as well as in modern medicine and articles, the effects and application of this plant in the field of medicine and nutrition have been mentioned. Conclusion: The results have shown that the use of ginger in nutrition as a spice or supplement and in Persian medicine as a medicament has a scientific and practical basis, and studies on this issue are confirmed both in science and Islam. Findings obtained from laboratory and clinical studies can also be effective in the proper use and preparation of appropriate medicinal forms of this plant.

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Pharmacological properties of paliperidone ER (INVEGA®) and results of its clinical studies

Folia Pharmacologica Japonica ◽

10.1254/fpj.137.245 ◽

2011 ◽

Vol 137 (6) ◽

pp. 245-254 ◽

Cited By ~ 1

Author(s):

Kenji Nagino ◽

Tadaishi Koh ◽

Yasushi Harada

Keyword(s):

Clinical Studies ◽

Pharmacological Properties

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A Review of the Ephedra genus: Distribution, Ecology, Ethnobotany, Phytochemistry and Pharmacological Properties

Molecules ◽

10.3390/molecules25143283 ◽

2020 ◽

Vol 25 (14) ◽

pp. 3283

Author(s):

Daphne E. González-Juárez ◽

Abraham Escobedo-Moratilla ◽

Joel Flores ◽

Sergio Hidalgo-Figueroa ◽

Natalia Martínez-Tagüeña ◽

...

Keyword(s):

Chemical Constituents ◽

Nasal Congestion ◽

Building Blocks ◽

Relevant Information ◽

Chemical Diversity ◽

Future Research ◽

Pharmacological Properties ◽

Ecological Interactions ◽

Phytochemical Study ◽

Promising Area

Ephedra is one of the largest genera of the Ephedraceae family, which is distributed in arid and semiarid regions of the world. In the traditional medicine from several countries some species from the genus are commonly used to treat asthma, cold, flu, chills, fever, headache, nasal congestion, and cough. The chemical constituents of Ephedra species have been of research interest for decades due to their contents of ephedrine-type alkaloids and its pharmacological properties. Other chemical constituents such as phenolic and amino acid derivatives also have resulted attractive and have provided evidence-based supporting of the ethnomedical uses of the Ephedra species. In recent years, research has been expanded to explore the endophytic fungal diversity associated to Ephedra species, as well as, the chemical constituents derived from these fungi and their pharmacological bioprospecting. Two additional aspects that illustrate the chemical diversity of Ephedra genus are the chemotaxonomy approaches and the use of ephedrine-type alkaloids as building blocks in organic synthesis. American Ephedra species, especially those that exist in Mexico, are considered to lack ephedrine type alkaloids. In this sense, the phytochemical study of Mexican Ephedra species is a promising area of research to corroborate their ephedrine-type alkaloids content and, in turn, discover new chemical compounds with potential biological activity. Therefore, the present review represents a key compilation of all the relevant information for the Ephedra genus, in particular the American species, the species distribution, their ecological interactions, its ethnobotany, its phytochemistry and their pharmacological activities and toxicities, in order to promote clear directions for future research.

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