Connecting the Dots Between Mental and Menstrual Health: An Exploratory Review

Context: Mental and menstrual health, two emerging aspects of health critical to the female population, are bidirectionally linked. But there is limited empirical evidence that establishes the association between these entities. This essay aims to draw the attention of researchers to this healthcare niche. Evidence Acquisition: An exploratory review was carried out on literatures sourced from medical databases (e.g. PubMed, Google Scholar, Scopus, Science Direct, and Web of Science), and gray sources-popular and reputable institutional and journalistic websites that publishes mental or menstrual health research. The key words used for the search are “menstruation, menstrual hygiene, menstrual disorders, premenstrual syndrome, period poverty, menarche, menopause, mental health, mental disorder, mental illness, depression, anxiety, phobia, mania, mood, and affect”. The initial search generated 368 results. But after the duplicates were removed, the exclusion criteria (publication before 2000, and in languages other than English) was applied, and manual review of abstract (for relevance) was done, 21 publications from the databases and 5 from gray sources were included in this review. Results: Associations were found between menstrual cycle irregularities and disorders; and mental disorders such as premenstrual syndrome, premenstrual dysphoric disorder, major depressive disorder, major anxiety disorder, psychotic disorder, bipolar disorder, borderline personality disorder, sleep disorder, substance use/abuse, and suicidal ideation and attempts. Few positive associations between mental and menstrual health were recorded, and several research and treatment gaps were identified. Conclusions: Research into the links between mental and menstrual health should not remain a fringe area of scientific curiosity, as it shows tremendous promise in improving healthcare offered to women/girls globally.

Abhava pratinidhi dravya: A Comparative Phytochemical Study of Bharangi and Kantakari

Abhava pratinidhi dravya excites the scientific curiosity concerning the Ayurvedic principles behind selection of the substitute drug. Present study had reported a comparative phytochemical study of one such Ayurvedic substitution pair: Solanum surattense Burm.f., a substitute for Clerodendrum serratum L. The study was conducted to understand the logic behind the Abhava pratinidhi dravya (Drug substitution). The strategy was to scrutinize and compare their Ayurvedic properties by literary studies and test the phytochemical profile of these two herbs for biochemical similiarties and differences. On analyzing their Ayurvedic pharmacology (Dravyaguna properties), findings show that both the drugs possess katu and tikta rasa, but Bharangi is katu rasa dominant and Kantakari is tikta rasa dominant drug. Along with this, both drug possess laghu, ruksha and ushna guna in common. Kantakari which contain different properties i.e. sara and tikshna guna. Both drug possess katu vipaka and ushna veerya. Both drugs had been stated to treat majority of respiratory ailments. Phytochemical observations suggest that in Bharangi root extract alkaloids and tannins was present whereas Kantakari root extract was rich in flavonoids content. Saponins was present in maximum amount in both the plant extracts. Despite taxonomically unrelated and morphologically dissimiliar, Bharangi has been substituted by Kantakari drug. In Ayurveda, more importance was given to pharmacological properties of raw drug rather than its botanical classification. Further comparative pre-clinical studies and bio-equivalence clinical studies has been needed to explore the different pharmacological properties.

An Unexpected Ally

In the summer of 1660, a strange phenomenon followed Mount Vesuvius’s eruption: red or black crosses started appearing on people’s linen, clothes, and even limbs. Since the Neapolitan people feared that the crosses were a supernatural occurrence and a terrible omen, the political and ecclesiastical leaders promoted the publication of books providing reasonable and pious explanations of the phenomenon. Among the authors who intervened in the debate over the nature of the crosses were Carlo Calà (who was hoping to gain favor with both the Viceroy and the Pope) and Athanasius Kircher, one of the leading protagonists of early modern Catholic culture. This chapter explains how the common interest in the crosses and Kircher’s scientific curiosity for fossils and giants provided Carlo with the opportunity to approach Kircher and make him aware of the case of his ancestor Giovanni, with the hope that the illustrious Catholic intellectual might support it.

Evaluating the Anticarcinogenic Activity of Surface Modified/Functionalized Nanochitosan: The Emerging Trends and Endeavors

Chitosan begins its humble journey from marine food shell wastes and ends up as a versatile nutraceutical. This review focuses on briefly discussing the antioxidant activity of chitosan and retrospecting the accomplishments of chitosan nanoparticles as an anticarcinogen. The various modified/functionalized/encapsulated chitosan nanoparticles and nanoforms have been listed and their biomedical deliverables presented. The anticancer accomplishments of chitosan and its modified composites have been reviewed and presented. The future of surface modified chitosan and the lacunae in the current research focus have been discussed as future perspective. This review puts forth the urge to expand the scientific curiosity towards attempting a variety of functionalization and surface modifications to chitosan. There are few well known modifications and functionalization that benefit biomedical applications that have been proven for other systems. Being a biodegradable, biocompatible polymer, chitosan-based nanomaterials are an attractive option for medical applications. Therefore, maximizing expansion of its bioactive properties are explored. The need for applying the ideal functionalization that will significantly promote the anticancer contributions of chitosan nanomaterials has also been stressed.

Volunteers for clinical trials: from the history of abuses and exploitation to the inclusion movement, and to an income resource

Medical research is essential to develop new and better therapies, increase social standards and a better life for all of us. Scientific curiosity has helped to achieve many successful innovations, but history also demonstrates that research can lead to abuses of individuals neglecting autonomy and integrity of the human being. Since the 1960ies we have witnessed a continuous development of international regulations and ethics guidelines (soft law) in medical research, leading to a higher quality of scientific results. An important focus lies on recognizing human vulnerability and a therefore adapted informed consent procedure. Our modern clinical trials structure requires the inclusion of healthy volunteers in the first phases of the development of a new medicinal product, leading to new ethical questions and challenges. The Corona-Pandemic has accelerated vaccine development in a successful way also leading to a new importance of healthy volunteers in the medical research landscape.

EPISTIMOLOGICAL METHOD SCIENCE ENTRY TO THE CURRICULUM IN THE SOCIOLOGICAL FIELD OF SOCIAL SCIENC )RATIONALITY THE SCIENCE BY EMILE DHURKHEIM AND GASTON BACHLARD)

The scientific approach is the method used to study a particular topic to achieve a particular goal, which leads to revealing truth in social sciences, which is characterized by the rationality of the biological knowledge, as the total endeavors adopted by the researcher reveal in a broad sense his vision or approach to research, that this approach is not determined in a vague way. But it is based on well-thought-out and revised proposals that allow it to implement its steps rigorously with the help of tools and means to ensure its success, while at the same time the validity of the endeavor, that is, the way in which these two aspects, the approach and health, are interrelated. If the endeavor is not systematic, success will be only superficial or superficial. Eimel Dur Kayem identified the principles of the sociological approach in his study of social life and stressed that "social realities should be treated as things". This falls within the general framework of modern and contemporary rationality. Gaston Bachelard (1884-1962) considered it an Epistemological crisis that we should overcome, in other words, the events of the Epistemological rupture. Scientific curiosity motivates us to ask the following question: – What is the geomorphological nature of the scientific method in light of the sociological field of science?

Cultural and Historical Preservation through Onomastic Materials: A Case of Toponyms and Anthroponyms in Kinyarwanda

Proper names, also linguistically called toponyms and anthroponyms, embed extensive sociolinguistic, cultural, and historical aspects in the life of any nation. Thus, they have caught the researcher’s attention because of the cultural and historical heritage they preserve in the context of language contact. From one place to another, and one specific period to another, anthroponyms and toponyms offer a wide range of research because of the scientific curiosity researchers have as to know why the name of a person or place exists, where it comes from, who named it, and when it was named so. In other words, the research is carried within spatial and temporal scope. Anthroponymy is the study of proper names of human beings, both individual and collective, while toponymy is the study of proper names of places. This paper aims at showing how place and person names embed cultural and historical features necessary to understand, explain, and preserve a people’s culture and history for a given period. The method used to research this topic is descriptive and it is based on the materials observed from various sources such as street names, hoardings, individual names, just to name a few. Therefore, this study focuses on specific topologies and periods, i.e. names denoting locations where the Rwandan territory has extended in the precolonial, colonial, postcolonial periods, and post-genocide periods.

Teaching and Research in Colonial Bombay

Bombay did not play the kind of administrative nodal role that first Madras and later Calcutta did in terms of overarching governance in the Indian subcontinent, occupying instead a pivotal position for the region’s commerce and industry. Nonetheless, the nineteenth and twentieth centuries in Bombay were a formative age for education and research in science, as in the other Presidencies. A colonial government, a large native population enrolled in the new European-style educational system, and the rise of several institutions of instruction and learning, fostered an environment of scientific curiosity. The Asiatic Society of Bombay (1804), which was initially the hub of research in all disciplines, became increasingly antiquarian and ethnographic through the course of the nineteenth century. The Victoria and Albert Museum (conceived in 1862 and built by 1871 and opened to the public in 1872), was established to carry out research on the industrial arts of the region, taking for its original collections fine and decorative arts that highlight practices and crafts of various communities in the Bombay Presidency. The University of Bombay (1857) was primarily tasked with teaching, and it was left to other establishments to conduct research. Key institutions in this regard included the Bombay Natural History Society (1883) given to local studies of plants and animals, and the Haffkine Institute (1899), which examined the role of plague that had been a dominant feature of the social cityscape from 1896. The Royal Institute of Science (1920) marked a point of departure, as it was conceived as a teaching institution but its lavish funding demanded a research agenda, especially at the post-graduate level. The Prince of Wales Museum (1922) would prove to be seminal in matters of collection and display of objects for the purpose of research. All of these institutions would shape the intellectual debates in the city concerning higher education. Typically founded by European colonial officials, they would increasingly be administered and staffed by Indians.

Recent Advances in Microneedle Platforms for Transdermal Drug Delivery Technologies

In many clinical applications, the transdermal route is used as an alternative approach to avoid the significant limitations associated with oral drug delivery. There is a long history for drug delivery through the skin utilizing transdermal microneedle arrays. Microneedles are reported to be versatile and very efficient devices. This technique has spurred both industrial and scientific curiosity, due to its outstanding characteristics such as painless penetration, affordability, excellent medicinal efficiency, and relative protection. Microneedles possess outstanding properties for diverse biomedical uses such as the delivery of very large substances with ionic and hydrophilic physicochemical properties. Importantly, microneedles are applicable in numerous biomedical fields such as therapy, diagnosis, and vaccine administration. Microneedles are emerging tools that have shown profound potential for biomedical applications. Transdermal microneedle technologies are likely to become a preferred route of therapeutic substances administration in the future since they are effective, painless, and affordable. In this review, we summarize recent advances in microneedles for therapeutic applications. We explore their constituent materials and fabrication methods that improve the delivery of critical therapeutic substances through the skin. We further discuss the practicality of advanced microneedles used as drug delivery tools.