Under the current market economy system, the market’s demand for application-oriented talents continues to increase, and the requirements for the comprehensive literacy and capabilities of talents are more stringent. In the new era, applied undergraduate colleges and universities must adapt to the changes in talent needs, and must do a good job of innovation in talent teaching management, optimizing the construction of curriculum teaching management mode, and promoting the realization of efficient talent training goals based on talent training goals and needs. In this regard, this article introduces the basic requirements of applied undergraduate talents under the new situation, analyzes the current basic status of talent teaching management in applied undergraduate colleges, and explores effective countermeasures for applied undergraduate talent teaching management under the new situation.