Clinical Efficacy and Recurrence Rate of Metronidazole Suppository Combined with Interferon Suppository in the Treatment of Chronic Cervicitis

Pelvic inflammatory disease (PID) is a sexually-transmitted infection (STI); and, as such, sometimes it is difficult to treat because of partner(s) issues. PID generally is accompanied by chronic cervicitis (CC). We observed that in spite of patients strictly complying with their therapy, there are some individuals that develop recurrent disease; and we tried to establish a relationship between CC and its recurrence in such patients. This study was prospectively designed. Patients in one group were treated with electrocauterization and another group who did not receive this therapy was retrospectively compared by reviewing their clinical records. Patients with CC and PID who did not undergo electrocauterization had 82% recurrence rate compared to those who underwent electrocauterization, who showed a 24% recurrence rate. We concluded that patients who had CC with different manifestations and who underwent electrocauterization or cervical fulguration developed significantly less recurrence of PID.

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Xiao Chai Hu Tang for Peptic Ulcers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/6693677 ◽

2021 ◽

Vol 2021 ◽

pp. 1-13

Author(s):

Min Li ◽

Wenchao Dan ◽

Hui Zhang ◽

Yong’en Yun ◽

Qingyong He

Keyword(s):

Systematic Review ◽

Randomized Controlled Trials ◽

Recurrence Rate ◽

Clinical Efficacy ◽

Meta Analysis ◽

Controlled Trials ◽

Efficacy Rate ◽

Peptic Ulcers ◽

Randomized Controlled ◽

Stomach Pain

A peptic ulcer (PU) is a digestive disorder most commonly found in clinical practice. An oriental herbal formula, Xiao Chai Hu Tang (XCHT), has been used to treat PU for an extended period in China. The effectiveness and safety of XCHT in treating peptic ulcers was evaluated using a systematic review of randomized controlled trials (RCTs). Studies were systematically retrieved from CNKI, Embase, Medline, PubMed, SinoMed, VIP, Wanfang, and Web of Science. The following information was extracted from the relevant RCTs: the clinical efficacy rate, recurrence rate, clinical efficacy of traditional Chinese medicine, and the adverse effects. 13 RCTs, including 1334 patients, were included in this review. The meta-analysis showed that treatment with XCHT was superior to conventional pharmacotherapy (CPT) in improving the clinical efficacy rate (RR: 1.20, 95% confidence intervals (CIs): 1.08–1.34, P = 0.0007 ), poor appetite (RR: 0.30, 95% CI: 0.15–0.61, P = 0.0009 ), abdominal distension (RR: 0.61, 95% CI: 0.39–0.96, P = 0.03 ), vomiting (RR: 0.33, 95% CI: 0.19–0.55, P < 0.0001 ), and stomach pain (RR: 0.36, 95% CI: 0.19–0.68, P = 0.002 ) and reducing adverse events (RR: 0.23, 95% CI: 0.07–0.69, P = 0.009 ). XCHT considerably increased the total clinical efficacy rate (RR: 1.22, 95% CI: 1.15–1.30, P < 0.00001 ) as both monotherapy and adjunctive therapy. The recurrence rate (RR = 0.29; 95% CI: 0.16–0.52, P < 0.0001 ) was remarkably decreased in the XCHT plus CPT group. The meta-analysis did not show a significant beneficial effect of XCHT compared with CPT in reducing the recurrence rate (RR = 0.45; 95% CI: 0.07–3.10, P = 0.42 ) and acid reflux (RR: 0.76, 95% CI: 0.47–1.23, P = 0.26 ). Our findings show that XCHT can treat peptic ulcers as part of an alternative medicine approach.

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A meta-analysis of the clinical efficacy of the combination of acupuncture and Chinese medicine in the treatment of haemorrhoids

Acupuncture & Electro-Therapeutics Research ◽

10.3727/036012919x15650315071915 ◽

2019 ◽

Vol 44 (2) ◽

pp. 89-104

Author(s):

Mengjie Zeng ◽

Xueli Cheng ◽

Geer Chen ◽

Jiyou Kou

Keyword(s):

Chinese Medicine ◽

Recurrence Rate ◽

Clinical Efficacy ◽

Randomized Clinical Trials ◽

Clinical Decision Making ◽

Meta Analysis ◽

Effective Rate ◽

Control Group ◽

Clinical Effects ◽

Pruritus Ani

At present, surgical resection is the main method of the treatment of haemorrhoids, but is easy to recur after surgery. Recently, it is reported that acupuncture has a beneficial influence on haemorrhoids. Thus, whether acupuncture is effective in the treatment of haemorrhoids is the key in this meta-analysis. To evaluate the clinical efficacy of the treatment of combination of acupuncture and Chinese medicine in haemorrhoids by meta-analysis, which provide a scientific, effective and feasible evidence for clinical decision-making and practice. A systematic review and meta-analysis of randomized clinical trials (RCTs). A meta-analysis was performed by using Review Manager 5.3. All RCTs about combination of acupuncture and Chinese medicine versus Chinese medicine alone were selected and assessed for inclusion. The effective rate (ER), recurrence rate(RR), Symptom score before and after treatment (perianal edema, hemafecia, perianal pain, pruritus ani, prolapse of haemorrhoids) were the outcomes analyzed in this meta-analysis. II RCTs and 976 patients were included. The methodological quality of most included trials was low to moderate. In this meta-analysis, the clinical efficacy of combination of acupuncture and Chinese medicine was more effective than only Chinese medicine used in haemorrhoids. The effective rate [OR=5.24,95%CI(3.72,7.40), P<O. OOOOI], recurrence rate [OR=O.29, 95%CI(O. II, O.73), P=O.009], perianal edema [WMD=-O.74,95%CI-O.90 to-O.59, P<O. OOOOI], hemafecia[WMD=-O.78,95%CI-O.89 to-O.67. P<O. OOOOI], perianal pain[WMD=-O.72,95%CI-O.94 to-O.50, P<O. OOOOI], pruritus ani[WMD=-O.75,95%CI-O.92 to-O.58, P<O. OOOOI] and prolapse of haemorrhoids[WMD=-0.43,95%CI-O.84 to-O.02, P=O.04] were shown in this meta-analysis.(OR:odds ratio;CI:confidence interval;WMD: weighted mean difference). There was about 96% of the clinical efficiency in the treatment of acupuncture plus Chinese medicine in haemorrhoids and 89% of that used in Chinese medicine alone, which indicates clearly that 7% higher efficiency in the experimental group compared with the control group. The treatment of combination of acupuncture and Chinese medicine in haemorrhoids is more useful than Chinese medicine alone applied in piles, which is shown in 91% of clinical effects in average.

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Acupuncture Treatment of Non-inflammatory Chronic Prostatitis with

Acupuncture & Electro-Therapeutics Research ◽

10.3727/036012921x16304136917609 ◽

2021 ◽

Author(s):

Zhang AJ ◽

He Y ◽

Chen F ◽

Chen H ◽

Jiang B ◽

...

Keyword(s):

Recurrence Rate ◽

Symptom Score ◽

Clinical Efficacy ◽

Chronic Prostatitis ◽

Depression Scale ◽

Safety Evaluation ◽

Acupuncture Group ◽

Hamilton Depression Scale ◽

Pain Symptom ◽

Better Than

Objective: To compare the clinical efficacy of "Tiao Shen Jie Yu" acupuncture, conventional acupuncture, and tamsulosin to treat non-inflammatory chronic prostatitis (type IIIB CP). Methods: 105 patients were randomly divided into the "Tiao Shen Jie Yu" acupuncture group, conventional acupuncture group, and tamsulosin group, 35 cases in each group. In the "Tiao Shen Jie Yu" acupuncture group, PC6 (Neiguan), PC7 (Daling), HT7 (Shenmen), RN6 (Qihai), RN4 (Guanyuan), ST28 (Shuidao), ST36 (Zusanli), SP9 (Yinlingquan), SP6 (Sanyinjiao), and LR3 (Taichong) were selected; In the conventional acupuncture group, RN4 (Guanyuan), RN3 (Zhongji), KI3 (Taixi), SP6 (Sanyinjiao), BL54 (Zhibian) through ST28 (Shuidao), BL20 (Pishu), and BL23 (Shenshu) were set. Acupuncture was given once every other day, 30 minutes each time, three times a week, 12 times in a row as a course of treatment. Tamsulosin group took tamsulosin 0.2mg orally, once a day for four weeks. The three groups were observed for two methods. The NIH-CPSI total score, NIH-CPSI pain symptom score, Hamilton Depression Scale (HAMD) score, and Hamilton Anxiety Scale (HAMA) score were compared among the three groups. After one course of treatment and after two methods of treatment, and the recurrence rate and clinical efficacy were evaluated. Results: The NIH-CPSI total score, NIH-CPSI pain symptom score, HAMD and HAMA scores of the three groups after one course of treatment and two courses of treatment were lower than those before treatment (all P<0.01). After one course of treatment and two courses of treatment, the total NIH-CPSI score, NIH-CPSI pain score, HAMD, and HAMA score in the "Tiao Shen Jie Yu" acupuncture group decreased more than those in the conventional acupuncture group and tamsulosin group (all P<0.05). The recurrence rate of the "Tiao Shen Jie Yu" acupuncture group was lower than that of the conventional acupuncture group and tamsulosin group, and the difference was statistically significant (P<0.05). The total effective rates of the conventional acupuncture group and tamsulosin group were 78.13% (25/32) and 69.70% (23/33), respectively, which were lower than 97.06% (33/34) of the "Tiao Shen Jie Yu" acupuncture group. No severe adverse reactions occurred in the safety evaluation. Conclusion: The therapeutic effect of "Tiao Shen Jie Yu" Acupuncture on type III BCP is better than that of conventional acupuncture and tamsulosin, and it is better than that of traditional acupuncture and tamsulosin in relieving prostatitis symptoms, anxiety, and depression.

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A combined ultrastructural and gene molecular research for the relationship between human uterine cervical carcinoma and human papillomavirus

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010015856x ◽

1990 ◽

Vol 48 (3) ◽

pp. 204-205

Author(s):

Kun Lee ◽

Jingyi Si ◽

Ricai Han ◽

Wei Zhang ◽

Bingbing Tan ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Intraepithelial Neoplasia ◽

Hpv Infection ◽

Dot Blot ◽

Homologous Sequences ◽

Normal Cervical Epithelium ◽

The Relationship ◽

Chronic Cervicitis

There are more supports for the view that human papillomavirus (HPV) infection might be an etiological factor in the development of cervical cancer when the association of persistent condylomata is considered. Biopsies from 318 cases with squamous cell carcinoma of uterine cervix, 48 with cervical and vulvar condylomata, 14 with cervical intraepithelial neoplasia (CIN), 34 with chronic cervicitis and 24 normal cervical epithelium were collected from 5 geographic regions of China with different cervical cancer mortalities. All specimens were prepared for Dot blot, Southern blot and in situ DNA-DNA hybridizations by using HPV-11, 16, 18 DNA labelled with 32P and 3H as probes to detect viral homologous sequences in samples. Among them, 32 cases with cervical cancer, 27 with condyloma and 10 normal cervical epitheliums were randomly chosen for comparative EM observation. The results showed that: 1), 192 out of 318 (60.4%) cases of cervical cancer were positive for HPV-16 DNA probe (Table I)

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