Analysis on the Value of Erythrocyte Parameters in Blood Test in the Differential Diagnosis of Anemia

2021 ◽  
2021 ◽  
Vol 18 (3) ◽  
pp. 103-103
Author(s):  
V. G.

When carrying out a differential diagnosis between these two diseases, the blood test for lymphocytes does not have, according to Weinberg (Deut. Med. Woch .. 1921, no. 29), the significance that Moeves is trying to ascribe to it. True, according to Weinberg's observations, lymphopenia in stomach cancer occurs more often than in achilia gastrica, where, on the contrary, it is more often possible to ascertain lymphocytosis, but the difference here is not so great as to base the diagnosis on one attribute.


2021 ◽  
Vol 16 (3) ◽  
pp. 245-250
Author(s):  
O.M. Raznatovska ◽  
Yu.V. Mironchuk

Background. The clinical and radiological picture of pulmonary tuberculosis has many common features with a large number of diseases. Therefore, differential diagnosis is very important when detecting tuberculosis. The purpose of the work: on the example of a clinical case to present the complexity of the differential diagnosis between pulmonary lesion in visceral toxocariasis and tuberculosis in children. Results. The child was diagnosed with an infiltrate in the third segment of the left lung with lesions of the intrathoracic lymph nodes, which is characteristic of the primary tuberculosis. The volatility of the infiltrate was not determined. All general blood test hadn’t shown an increase in eosinophils and white blood cells. According to the literature data, the appearance of persistent and prolonged eosinophilia with the development of eosinophilic leukemoid reactions of the blood, an increase in the level of leukocytes are the main and one of the constant manifestations of toxocariasis. The child was diagnosed with moderate hepatomegaly, which is cha­racteristic for both diseases. The patient was registered at a pediatric tuberculosis clinic due to a shift in tuberculin tests. At the time of hospitalization, there were not reasons to suspect visceral toxocariasis. Due to the examination data, first of all the absence of bacterial excretion and negative tuberculin tests, and the pre­sence in the child’s house of the dogs and cats, it was decided to recommend the consultation of the infectionist to exclude any parasitic disease. At the end, the correct diagnosis was established in this child at time and the necessary treatment was prescribed. Conclusions. This clinical case demonstrates the difficulties of differential diagnosis of visceral toxocariasis in lung lesion and tuberculosis. First of all, this is due to the asymptomatic clinical picture of toxocariasis, the diagnosis of which was established by X-ray data, blood test for IgG antibodies to Toxocara and epidemiological history. Given the fact that toxocariasis includes a large spectrum of masks of various diseases, and children who are infected by Toxocara do not have specific clinical symptoms, doctors should remember to prescribe the additional examination for the presence of parasitic diseases, including toxocariasis, especially if pets live in the child’s home.


Author(s):  
Дмитрий Валериевич Судаков ◽  
Олег Валериевич Судаков ◽  
Артём Николаевич Шевцов ◽  
Евгений Владимирович Белов

В статье рассматриваются некоторые особенности выявления больных с «кишечной формой» новой коронавирусной инфекцией у пациентов хирургического профиля на уровне приемного отделения многопрофильного стационара. Данная тематика является весьма актуальной, так как после начала пандемии Covid-19 в 2020 году, было выявлено несколько отличающихся течением, форм заболевания, одной из которых и стала, так называемая «кишечная форма». Большой интерес обусловлен тем, что при данном виде течения патологического процесса практически отсутствуют характерные для Covid-19 симптомы - болезнь, зачастую, маскируется под клинику «острого живота», в виду чего в ряде случаев диагностика ложиться на плечи врачей хирургического профиля. Данная работа стала результатом попытки выявить основные закономерности развития и особенности «течения» у пациентов данной патологии, с выявлением основных клинических симптомов, которые могли бы своевременно помочь с адекватной дифференциальной диагностикой. Объектами исследования послужило 150 пациентов, мужчин и женщин, в возрасте от 19 до 79 лет, мужчин (n=91) и женщин (n=59). Все больные были разделены на 3 группы по 50 человек. В первую группу вошли больные, у которых была выявлена одна из существующих острых хирургических патологий. Вторую группу составили пациенты, у которых была диагностирована «кишечная форма» новой коронавирусной инфекции. В третью группу вошли пациенты, которые ранее уже перенесли Covid-19. В основу исследования лег подробное изучение всех жалоб пациентов. Так были установлены определенные различия между рядом жалоб у пациентов различных групп. Однако ведущим симптомом, заставившем всех больных обратиться в стационар, был болевой синдром. В дальнейшем в работе проведен комплексный анализ боли, ее характер и особенности локализации в зависимости от группы. Важной частью исследования стало также изучение общего анализа крови и биохимического анализа крови, с выделением основных показателей, способных оказать помощь в дифференциальной диагностике. В завершении исследования проводилось изучение данных УЗИ и методов специфической диагностики новой коронавирусной инфекции, позволяющих получить первичные данные о процессе формирования иммунитета после перенесенного Covid-19. Статья интересна прежде всего врачам, занимающимся первичным приемом пациентов в стационарах и поликлиниках The article discusses some of the features of identifying patients with "intestinal form" of new coronavirus infection in surgical patients at the level of the admission department of a multidisciplinary hospital. This topic is very relevant, since after the start of the Covid-19 pandemic in 2020, several different forms of the disease were identified, one of which became the so-called "intestinal form". The great interest is due to the fact that with this type of pathological process, there are practically no symptoms characteristic of Covid-19 - the disease is often disguised as an acute abdomen clinic, which means that in some cases, the diagnosis falls on the shoulders of surgical doctors. This work was the result of an attempt to identify the main patterns of development and features of the "course" in patients with this pathology, with the identification of the main clinical symptoms that could promptly help with adequate differential diagnosis. The objects of the study were 150 patients, men and women, aged 19 to 79, men (n = 91) and women (n = 59). All patients were divided into 3 groups of 50 people each. The first group included patients who had one of the existing acute surgical pathologies. The second group consisted of patients who were diagnosed with the "intestinal form" of a new coronavirus infection. The third group included patients who had previously suffered from Covid-19. The study was based on a detailed study of all patient complaints. Thus, certain differences were established between a number of complaints in patients of different groups. However, the leading symptom that made all patients go to the hospital was pain syndrome. In the future, a comprehensive analysis of pain, its nature and localization characteristics depending on the group was carried out. An important part of the study was also the study of a general blood test and a biochemical blood test, with the identification of the main indicators that can help in differential diagnosis. At the end of the study, the study of ultrasound data and methods of specific diagnostics of a new coronavirus infection was carried out, which make it possible to obtain primary data on the formation of immunity after the transferred Covid-19. The article is of interest primarily to doctors engaged in the primary admission of patients in hospitals and clinics


2004 ◽  
Vol 93 (4) ◽  
pp. 328-333 ◽  
Author(s):  
Alessandro Fiocchi ◽  
Roberto Besana ◽  
Ann-Christine Rydén ◽  
Luigi Terracciano ◽  
Massimo Andreotti ◽  
...  

2021 ◽  
Author(s):  
Motohisa Yamamoto ◽  
Masanori Nojima ◽  
Ryuta Kamekura ◽  
Akiko Kuribara-Souta ◽  
Masaaki Uehara ◽  
...  

Abstract Introduction: To eliminate the disparity and maldistribution of physicians and medical specialty services, the development of diagnostic support for rare diseases using artificial intelligence is being promoted. Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a rare disorder often requiring special knowledge and experience to diagnose. In this study, we investigated the possibility of differential diagnosis of IgG4-RD based on basic patient characteristics and blood test findings using machine learning. Methods Six-hundred and two patients with IgG4-RD and 212 patients with non-IgG4-RD that needed to be differentiated who visited the participating institutions were included in the study. Ten percent of the subjects were randomly excluded as a validation sample. Among the remaining cases, 80% were used as training samples, and the remaining 20% were used as test samples. Finally, validation was performed on the validation sample. The analysis was performed using a decision tree and a random forest model. Furthermore, a comparison was made between conditions with and without the serum IgG4 concentration. Accuracy was evaluated using the area under the receiver-operating characteristic (AUROC) curve. Results In diagnosing IgG4-RD, AUROC curve values of the decision tree and the random forest method were 0.905 and 0.970, respectively, when serum IgG4 levels were included in the analysis. Excluding serum IgG4 levels, the AUROC curve value of the analysis by the random forest method was 0.919. Conclusion Based on machine learning in a multicenter collaboration, with or without serum IgG4 data, basic patient characteristics and blood test findings alone were sufficient to differentiate IgG4-RD from non-IgG4-RD.


Author(s):  
Bruce Mackay

The broadest application of transmission electron microscopy (EM) in diagnostic medicine is the identification of tumors that cannot be classified by routine light microscopy. EM is useful in the evaluation of approximately 10% of human neoplasms, but the extent of its contribution varies considerably. It may provide a specific diagnosis that can not be reached by other means, but in contrast, the information obtained from ultrastructural study of some 10% of tumors does not significantly add to that available from light microscopy. Most cases fall somewhere between these two extremes: EM may correct a light microscopic diagnosis, or serve to narrow a differential diagnosis by excluding some of the possibilities considered by light microscopy. It is particularly important to correlate the EM findings with data from light microscopy, clinical examination, and other diagnostic procedures.


2011 ◽  
Vol 21 (2) ◽  
pp. 59-62
Author(s):  
Joseph Donaher ◽  
Christina Deery ◽  
Sarah Vogel

Healthcare professionals require a thorough understanding of stuttering since they frequently play an important role in the identification and differential diagnosis of stuttering for preschool children. This paper introduces The Preschool Stuttering Screen for Healthcare Professionals (PSSHP) which highlights risk factors identified in the literature as being associated with persistent stuttering. By integrating the results of the checklist with a child’s developmental profile, healthcare professionals can make better-informed, evidence-based decisions for their patients.


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