scholarly journals Tissue-Based Immunohistochemical Markers for Diagnosis and Classification of Renal Cell Carcinoma

2020 ◽  
Vol 1 (1) ◽  
pp. 68-76
Author(s):  
Liang G Qu ◽  
Vaisnavi Thirugnanasundralingam ◽  
Damien Bolton ◽  
Antonio Finelli ◽  
Nathan Lawrentschuk
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Immunohistochemical Markers ◽  
Chromophobe Rcc ◽  
Specimen Collection ◽  
Renal Oncocytomas ◽  
Diagnosis And Classification ◽  
Tissue Biomarkers

The development and description of renal cell carcinoma (RCC) subtypes has led to an increase in demand for tissue biomarkers. This has implications not only in informing diagnosis, but also in guiding treatment selection and in prognostication. Although historically, many immunohistochemical (IHC) stains have been widely characterized for RCC subtypes, challenges may arise in interpreting these results. These may include variations in tumor classification, specimen collection and processing, and IHC techniques. In light of the reclassification of RCC subtypes in 2016, there remains a requirement for a comprehensive outline of tissue biomarkers that may be used to differentiate between RCC subtypes and distinguish these from other non-renal neoplasms. In this review, concise summaries of the commonest RCC subtypes, including clear cell, papillary, and chromophobe RCC, have been provided. Important differences have been highlighted between chromophobe RCC and renal oncocytomas. An overview of the current landscape of tissue biomarkers in other RCC subtypes has also been explored, revealing the variable staining results reported for some markers, whilst highlighting the essential markers for diagnosis in other subtypes.

scholarly journals Contemporary approach to diagnosis and classification of renal cell carcinoma with mixed histologic features

2013 ◽  
Vol 32 (6) ◽  
pp. 303-311 ◽  
Author(s):  
Kanishka Sircar ◽  
Priya Rao ◽  
Eric Jonasch ◽  
Federico A. Monzon ◽  
Pheroze Tamboli
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Diagnosis And Classification ◽  
Contemporary Approach

scholarly journals Identification and Classification of Differentially Expressed Genes in Renal Cell Carcinoma by Expression Profiling on a Global Human 31,500-Element cDNA Array

2001 ◽  
Vol 11 (11) ◽  
pp. 1861-1870 ◽  
Author(s):  
Judith M. Boer ◽  
Wolfgang K. Huber ◽  
Holger Sültmann ◽  
Friederike Wilmer ◽  
Anja von Heydebreck ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Differentially Expressed Genes ◽  
Expression Profiling ◽  
Renal Cell ◽  
Cdna Array ◽  
Differentially Expressed

scholarly journals MiT Family Translocation Renal Cell Carcinoma: from the Early Descriptions to the Current Knowledge

Cancers ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1110 ◽  
Author(s):  
Anna Caliò ◽  
Diego Segala ◽  
Enrico Munari ◽  
Matteo Brunelli ◽  
Guido Martignoni
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clinical Course ◽  
Current Knowledge ◽  
Wide Spectrum ◽  
Cathepsin K ◽  
World Health ◽  
Epithelioid Angiomyolipoma ◽  
Immunohistochemical Markers

The new category of MiT family translocation renal cell carcinoma has been included into the World Health Organization (WHO) classification in 2016. The MiT family translocation renal cell carcinoma comprises Xp11 translocation renal cell carcinoma harboring TFE3 gene fusions and t(6;11) renal cell carcinoma harboring TFEB gene fusion. At the beginning, they were recognized in childhood; nevertheless, it has been demonstrated that these neoplasms can occur in adults as well. In the nineties, among Xp11 renal cell carcinoma, ASPL, PRCC, and SFPQ (PSF) were the first genes recognized as partners in TFE3 rearrangement. Recently, many other genes have been identified, and a wide spectrum of morphologies has been described. For this reason, the diagnosis may be challenging based on the histology, and the differential diagnosis includes the most common renal cell neoplasms and pure epithelioid PEComa/epithelioid angiomyolipoma of the kidney. During the last decades, many efforts have been made to identify immunohistochemical markers to reach the right diagnosis. To date, staining for PAX8, cathepsin K, and melanogenesis markers are the most useful identifiers. However, the diagnosis requires the demonstration of the chromosomal rearrangement, and fluorescent in situ hybridization (FISH) is considered the gold standard. The outcome of Xp11 translocation renal cell carcinoma is highly variable, with some patients surviving decades with indolent disease and others dying rapidly of progressive disease. Despite most instances of t(6;11) renal cell carcinoma having an indolent clinical course, a few published cases demonstrate aggressive behavior. Recently, renal cell carcinomas with TFEB amplification have been described in connection with t(6;11) renal cell carcinoma. Those tumors appear to be associated with a more aggressive clinical course. For the aggressive cases of MiT family translocation carcinoma, the optimal therapy remains to be determined; however, new target therapies seem to be promising, and the search for predictive markers is mandatory.

scholarly journals Molecular Profiling and Classification of Sporadic Renal Cell Carcinoma by Quantitative Methylation Analysis

2004 ◽  
Vol 10 (21) ◽  
pp. 7276-7283 ◽  
Author(s):  
Mark L. Gonzalgo ◽  
Srinivasan Yegnasubramanian ◽  
Gai Yan ◽  
Craig G. Rogers ◽  
Theresa L. Nicol ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Molecular Profiling ◽  
Methylation Analysis ◽  
Sporadic Renal Cell Carcinoma

Chromophobe Renal Cell Carcinoma With Retrograde Venous Invasion and Gain of Chromosome 21: Potential Harbingers of Aggressive Clinical Behavior

2018 ◽  
Vol 26 (6) ◽  
pp. 536-541 ◽  
Author(s):  
Mohsin Jamal ◽  
Kanika Taneja ◽  
Sohrab Arora ◽  
Ravi Barod ◽  
Craig G. Rogers ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Aggressive Behavior ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Vein ◽  
Clear Cell ◽  
Venous Invasion ◽  
Chromosome 21 ◽  
Chromophobe Rcc ◽  
Clear Cell Rcc

Occasionally, renal cell carcinoma (RCC) with renal vein extension spreads against the flow of blood within vein branches into the kidney, forming multifocal nodules throughout the renal parenchyma. These foci are not regarded as multiple tumors but rather reverse spread of tumor along the venous system. This intravascular spread has previously been reported in clear cell RCC and RCC unclassified. However, to our knowledge, this has never been reported in chromophobe RCC. Chromophobe RCC is a unique histologic subtype of renal cancer, generally thought to have less aggressive behavior. However, it nonetheless has the potential to undergo sarcomatoid dedifferentiation, which is associated with poor prognosis. We report a unique case of a 65-year-old man with chromophobe RCC (pT3a) showing classic morphology (nonsarcomatoid), yet presenting with retrograde venous invasion and hilar lymph node metastasis at the time of right radical nephrectomy. Fluorescence in situ hybridization revealed gain of chromosome 21 with loss of multiple other chromosomes. Partial hepatectomy was performed to resect metastatic RCC 7 months after nephrectomy, revealing chromophobe RCC with classic morphology. Bone biopsy confirmed skeletal metastases 38 months after initial diagnosis. Although invasion of the renal vein and retrograde venous invasion are characteristically seen in clear cell RCC, this unusual phenomenon may also occur in chromophobe RCC, despite its unique tumor biology. This and gain of chromosome 21, which was postulated to be associated with aggressive behavior in a previous report, were associated with adverse behavior in our patient, who had short-term progression to multi-organ metastatic disease.

Abstract 3559: Long non-coding RNA subtype classification of clear-cell renal cell carcinoma

2014 ◽  
Author(s):  
Gabriel G. Malouf ◽  
Jianping Zhang ◽  
Nizar Tannir ◽  
Erika J. Thompson ◽  
David Khayat ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Subtype Classification ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Papillary renal cell carcinoma within a renal oncocytoma: Case report of very rare coexistence

2014 ◽  
Vol 8 (11-12) ◽  
pp. 928 ◽  
Author(s):  
Cevahir Özer ◽  
Mehmet Resit Gören ◽  
Tulga Egilmez ◽  
Nebil Bal
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Radical Nephrectomy ◽  
Papillary Renal Cell Carcinoma ◽  
Renal Oncocytoma ◽  
Renal Neoplasms ◽  
Renal Oncocytomas ◽  
Papillary Rcc

Renal oncocytomas accounts for 3% to 9% of primary renal neoplasms. The coexistence of renal cell carcinoma (RCC) within the oncocytoma is extremely rare. We report the case of an asymptomatic 74-year-old man with papillary RCC within oncocytoma managed with left radical nephrectomy.

Primary Apoptosis as a Prognostic Index for the Classification of Metastatic Renal Cell Carcinoma

2002 ◽  
Vol 168 (2) ◽  
pp. 460-464 ◽  
Author(s):  
E.N. Richter ◽  
K. Oevermann ◽  
N. Buentig ◽  
S. Störkel ◽  
I. Dallmann ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Index
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