Unwanted Muscle Weakness following Botulinum Neurotoxin A Administration in Spinal Cord Injury with Literature Review

2012 ◽  
Vol 23 (1) ◽  
pp. 20-24
Author(s):  
Tapan N Joshi
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Adverse Effects ◽  
Muscle Weakness ◽  
Botulinum Neurotoxin ◽  
Adult Population ◽  
Functional Decline ◽  
High Dose ◽  
Botulinum Neurotoxin A ◽  
Cord Injury

Abstract Botulinum neurotoxin A (BoNTA) is rapidly gaining acceptance for management of spasticity secondary to spinal cord injury (SCI). Due to its increased usage, more undesirable effects and complications have come in light. Unwanted distant and/or generalised muscle weakness is possible following BoNTA administration in SCI population causing temporary neurological and functional decline. Physicians should carefuly perform a clinical assessment of every patient individually for risks stratification. Additional studies for adult population evaluating adverse-effects of high dose of BoNTA treatment for spasticity management are indicated.

Implications of immunotherapy with high-dose glatiramer acetate in acute phase of spinal cord injury in rats

2019 ◽  
Vol 41 (1) ◽  
pp. 150-162 ◽  
Author(s):  
Hadi Askarifirouzjaei ◽  
Leila Khajoueinejad ◽  
Amir Salek Farrokhi ◽  
Mohammad-Taher Tahoori ◽  
Mehdi Fazeli ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Glatiramer Acetate ◽  
Acute Phase ◽  
High Dose ◽  
Cord Injury

scholarly journals Synthesis and Characterization of a Silica-Based Drug Delivery System for Spinal Cord Injury Therapy

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Guodong Sun ◽  
Shenghui Zeng ◽  
Xu Liu ◽  
Haishan Shi ◽  
Renwen Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Central Component ◽  
High Dose ◽  
Interleukin 17 ◽  
Cord Injury

Abstract Acute inflammation is a central component in the progression of spinal cord injury (SCI). Anti-inflammatory drugs used in the clinic are often administered systemically at high doses, which can paradoxically increase inflammation and result in drug toxicity. A cluster-like mesoporous silica/arctigenin/CAQK composite (MSN-FC@ARC-G) drug delivery system was designed to avoid systemic side effects of high-dose therapy by enabling site-specific drug delivery to the spinal cord. In this nanosystem, mesoporous silica was modified with the FITC fluorescent molecule and CAQK peptides that target brain injury and SCI sites. The size of the nanocarrier was kept at approximately 100 nm to enable penetration of the blood–brain barrier. Arctigenin, a Chinese herbal medicine, was loaded into the nanosystem to reduce inflammation. The in vivo results showed that MSN-FC@ARC-G could attenuate inflammation at the injury site. Behavior and morphology experiments suggested that MSN-FC@ARC-G could diminish local microenvironment damage, especially reducing the expression of interleukin-17 (IL-17) and IL-17-related inflammatory factors, inhibiting the activation of astrocytes, thus protecting neurons and accelerating the recovery of SCI. Our study demonstrated that this novel, silica-based drug delivery system has promising potential for clinical application in SCI therapy.

scholarly journals High dose compressive loads attenuate bone mineral loss in humans with spinal cord injury

2011 ◽  
Vol 23 (9) ◽  
pp. 2335-2346 ◽  
Author(s):  
S. Dudley-Javoroski ◽  
P. K. Saha ◽  
G. Liang ◽  
C. Li ◽  
Z. Gao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Mineral ◽  
High Dose ◽  
Bone Mineral Loss ◽  
Cord Injury ◽  
Compressive Loads ◽  
Mineral Loss

scholarly journals Neuroprotective effects of high-dose human albumin against traumatic spinal cord injury in rats

2018 ◽  
Vol 119 (02) ◽  
pp. 86-91
Author(s):  
T. Yildirim ◽  
O. Okutan ◽  
E. Akpinar ◽  
A. Yilmaz ◽  
H. S. Isik
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Human Albumin ◽  
High Dose ◽  
Traumatic Spinal Cord Injury ◽  
Neuroprotective Effects ◽  
Cord Injury

Consequences of High-Dose Steroid Therapy for Acute Spinal Cord Injury

1997 ◽  
Vol 42 (2) ◽  
pp. 279-284 ◽  
Author(s):  
S. J. Gerndt ◽  
J. L. Rodriguez ◽  
J. W. Pawlik ◽  
P. A. Taheri ◽  
W. L. Wahl ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Steroid Therapy ◽  
Acute Spinal Cord Injury ◽  
High Dose ◽  
High Dose Steroid ◽  
Cord Injury
Sign in / Sign up

Export Citation Format

Share Document