The Effect of Topical Application of Pure Honey on Radiation-induced Mucositis: A Randomized Clinical Trial

2008 ◽  
Vol 9 (3) ◽  
pp. 40-47 ◽  
Author(s):  
M. Motallebnejad ◽  
S. Akram ◽  
A. Moghadamnia ◽  
Z. Moulana ◽  
S. Omidi
Keyword(s):  
Clinical Trial ◽  
Radiation Therapy ◽  
Head And Neck ◽  
Randomized Clinical Trial ◽  
Topical Application ◽  
Control Group ◽  
Study Group ◽  
Early Effect ◽  
Radiation Induced ◽  
Natural Honey

Abstract Aim Radiation-induced mucositis is an early effect of head and neck radiotherapy. Mucositis can cause ulcers, and patients may experience pain and dysphasia which need treatment. The aim of this study is to evaluate the effect of pure natural honey on radiation induced mucositis. Methods and Materials In this randomized single blind (examiner blind) clinical trial 40 patients with head and neck cancer requiring radiation to the oropharyngeal mucosa were randomly assigned to two groups. Twenty patients assigned to the study group received honey, while both the study and control groups received standard head and neck radiation therapy based on a standard protocol. In the study group patients were instructed to take 20 ml of honey 15 minutes before radiation therapy, then again at intervals of 15 minutes and six hours after radiation. In the control group patients were instructed to rinse with 20 ml of saline before and after radiation. Patients were evaluated weekly for progression of mucositis using the Oral Mucositis Assessing Scale (OMAS). Data were analyzed using the independent t-test, Mann-Whitney, and Friedman tests. Results A significant reduction in mucositis among honey-received patients compared with controls (p=0.000) occurred. Conclusion Within the limits of this study the results showed the application of natural honey is effective in managing radiation induced mucositis. Clinical Significance Natural honey is a product with rich nutritional qualities that could be a pleasant, simple, and economic modality for the management of radiation mucositis. Citation Motallebnejad M, Akram S, Moghadamnia A, Moulana Z, Omidi S. The Effect of Topical Application of Pure Honey on Radiation-induced Mucositis: A Randomized Clinical Trial. J Contemp Dent Pract 2008 March; (9)3:040-047.

scholarly journals Minocycline for symptom reduction during radiation therapy for head and neck cancer: a randomized clinical trial

2019 ◽  
Vol 28 (1) ◽  
pp. 261-269 ◽  
Author(s):  
G. Brandon Gunn ◽  
Tito R. Mendoza ◽  
Adam S. Garden ◽  
Xin Shelley Wang ◽  
Qiuling Shi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Randomized Clinical Trial ◽  
Neck Cancer ◽  
Symptom Reduction

The Role of Pulsatile Cold Compression in Edema Resolution Following Ankle Fractures: A Randomized Clinical Trial

2002 ◽  
Vol 23 (11) ◽  
pp. 999-1002 ◽  
Author(s):  
Steve Mora ◽  
Charalampos G. Zalavras ◽  
Lingjun Wang ◽  
David B. Thordarson
Keyword(s):  
Clinical Trial ◽  
Patient Satisfaction ◽  
Randomized Clinical Trial ◽  
Bed Rest ◽  
Ankle Fractures ◽  
Control Group ◽  
Study Group ◽  
Time Points ◽  
Cold Compression

Twenty-four patients with displaced ankle fractures awaiting surgery were randomized to a study (n = 11) or a control group (n = 13). In the study group, patients had a pulsatile cold compression (PCC) device applied to their ankle, and remained at bed rest with the extremity elevated while awaiting surgery. In the control group patients remained in a posterior molded splint instead of the PCC device. Baseline circumferential measurements of the ankle were obtained, followed by measurements at 24-hour increments to evaluate edema resolution. In addition, patient satisfaction with use of the PCC device was evaluated with a scale ranging from 1 to 4. The median decrease of circumference in the study group compared to the control group was 0.5 cm vs. 0.1 cm at 24 hours (p=0.005), 0.9 cm vs. 0.4 cm at 48 hours (p<0.001), and 1.2 cm vs. 0.5 cm at 72 hours (p=0.009). The ratio of the decrease in circumference relative to the circumference of the normal ankle was significantly higher in the PCC group compared to the control group at all time points. All patients in the PCC group were satisfied with the device (median satisfaction score = 4). The PCC device was well tolerated and resulted in a significantly greater reduction of ankle circumference at 24, 48, and 72 hours after its application, compared to splinting and elevation alone. The PCC device facilitates edema resolution following ankle fractures.

scholarly journals A Comparative Study of Two Split Course Accelerated Hypo-fractionated Radiation Therapy (SCAHRT) Schedules in Locally Advanced Head and Neck Carcinoma

2020 ◽  
Vol 5 (7) ◽  
pp. 429-436
Author(s):  
Peoli Mukutawat ◽  
Vivek Kaushal ◽  
Rakesh Dhankhar ◽  
Rajeev Atri ◽  
Anil Kumar Dhull ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Radiation Dose ◽  
Head And Neck ◽  
Locally Advanced ◽  
Head And Neck Carcinoma ◽  
Control Group ◽  
Study Group ◽  
Repeat Dose ◽  
Advanced Head ◽  
Neck Carcinoma

Introduction: Head and neck cancers include malignant neoplasms that develop in the oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx and salivary glands. Out of the newly diagnosed patients of head and neck carcinoma in India, most of the patients present in locally advanced stage. Because of extensive local disease and associated co-morbidities and compromised KPS, palliative radiation therapy is preferred treatment for these patients. Material and methods: The study was conducted on 60 previously untreated, histo-pathologically proven patients of locally advanced head and neck cancer who were randomized in two equal groups by draw of lots. Study group received radiation dose of 30 Gy/ 10 fractions / 2 weeks followed by repeat dose of 30 Gy/ 10 fractions / 2 weeks (Total dose 60 Gy in 20 fractions delivered with a gap of 4 weeks). Control group received radiation dose of 20 Gy/ 5 fractions/ 5 days followed by repeat dose of 20 Gy/ 5 fractions/ 5 days followed by repeat dose of 20 Gy/ 5 fractions/ 5 days (Total dose 60 Gy in 3 sessions with a gap of 3 weeks each). Objectives were to compare efficacy of above schedules based on symptomatic relief and overall tumor response and to compare the toxicities of the above schedules. Results and Conclusion: To expedite the treatment time in tertiary care centres, control group (20 Gy / 5 fractions / 1 week; 3 weekly X 3) was better than the study group (30 Gy / 10 fractions / 2 weeks; 4 weekly X 2) as it had comparable local control and toxicity (acute mucosal reactions being slightly higher in the study group) with the added advantage of only 15 total fractions (machine days) in control group rather than 20 total fractions (machine days) in study group. This reduced the patient visits to the hospital by one week (i.e. 5 fractions) with comparable local control and toxicity.

scholarly journals EFFECTIVENESS OF TOPICAL APPLICATION OF MIXTURE OF HONEY AND COFFEE IN RADIATION INDUCED ORAL MUCOSITIS AMONG PATIENTS WITH HEAD & NECK CANCER UNDERGOING RADIOTHERAPY AT RADIOTHERAPY DEPARTMENT OF KGMU, LUCKNOW, U.P

2020 ◽  
Vol 8 (10) ◽  
pp. 55-62
Author(s):  
Anjali Verma ◽  
◽  
Rashmi P. John ◽  
Kirti Srivastava ◽  
◽  
...  
Keyword(s):  
Head And Neck ◽  
Neck Cancer ◽  
Oral Mucositis ◽  
Sampling Technique ◽  
Control Group ◽  
Study Group ◽  
Head Neck Cancer ◽  
Control Group Design ◽  
Quasi Experimental ◽  
Radiation Induced

Background: Cancers commonly known as head and neck cancers typically begin in the squamous cells that line the moist, mucosal surfaces within the head and neck. Oral mucositis is erythematous and ulcerative lesion of the oral mucosa in patients with cancer being treated with chemotherapy/ radiation therapy in the areas of oral cavity. Objectives: To assess the grade of the oral mucositis among head & neck cancer patients receiving radiotherapy. 2. To evaluate the effectiveness of mixture of honey and coffee application on radiation induced oral mucositis among the study group. 3. To find the association between the radiation induced oral mucositis with selected demographic variables. Method: quasi experimental non randomized control group design was applied and 60 samples (30 in each group) were selected by convenience sampling technique. The mixture of honey and coffee was applied to the study group before and after 15 minutes of radiotherapy till the continuation of radiotherapy and no intervention was given in the control group. Result: The result revealed that the application of honey and coffee mixture was significantly effective on oral mucositis (p<0.001) in the study group. Conclusion: The study concluded that, application of mixture of honey and coffee is an effective method of reducing the onset and severity of oral mucositis in comparison with no intervention.

scholarly journals Outcome of Anastomotic Urethroplasty in Posterior Urethral Distraction Defect With or Without Mucosal Fixation- a Randomized Clinical Trial

2020 ◽  
Vol 21 (1) ◽  
pp. 31-34
Author(s):  
Sayem Hossain ◽  
AKM Khurshidul Alam ◽  
Hasina Sadia Khan ◽  
Mohammad Salahuddin Faruque ◽  
Ismat Jahan ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Failure Rate ◽  
Flow Rate ◽  
Influencing Factor ◽  
Urine Flow ◽  
Urine Flow Rate ◽  
Control Group ◽  
Study Group ◽  
Anastomotic Urethroplasty

Introduction: Anastomotic urethroplasty is the treatment of choice for posterior urethral distraction defect. To notice the high failure rate of anastomotic urethroplasty, several peri-operative factors are identified. Among the per-operative factors, mucosal fixation of the both urethral ends is one of the outcome influencing factor that is recently identified. So, this randomized clinical trial has been designed to compare the outcome of anastomotic urethroplasty in posterior urethral distraction defects with or without mucosal fixation. Objective: To compare the outcome of anastomotic urethroplasty of PUDD patient groups with or without mucosal fixation in terms of post-operative IPSS, maximum urine flow rate and post void residual urine. Patients and Methods: The present study was conducted in the department of Urology, BSMMU between January’16 - November’17. Posterior urethral distraction defects with length of gap between two urethral segments upto 3 cm. were included in the study. The patients in whom anastomotic urethroplasty were done with mucosal fixation were enrolled as study group(n=21) and patients in whom anastomotic urethroplasty were done without mucosal fixation were included as control group(n=21). All the patients were followed upto 6 months of anstomotic urethroplasty and failure of anastomotic urethroplasty (by RGU and MCU), PVR and maximum urine flow rate (Qmax) in between two groups were compared. Result: The failure rate was found significantly higher in control group than in the study group (p=0.043). The control group showed highly significant (0.001) increase in postoperative PVR than the study group and the study group showed significant (0.007) increase in post operative maximum urine flow rate than the control group as was assumed in the hypothesis. Conclusion: In conclusion, it can be said that anastomotic urethroplasty with mucosal fixation is a better option than anstomotic urethroplasty without mucosal fixation. But multicentric trial is needed to further comment. Bangladesh Journal of Urology, Vol. 21, No. 1, January 2018 p.31-34

scholarly journals The neonatal outcomes of Dexamethasone administration before scheduled cesarean delivery at term: a randomized clinical trial

2020 ◽  
Vol 9 (3) ◽  
pp. 1222
Author(s):  
Shereen B. Elbohoty ◽  
Ayman S. Dawood ◽  
Ahmed M. Abbas ◽  
Adel E. Elgergawy
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Caesarean Delivery ◽  
Group Versus ◽  
World Health ◽  
Respiratory Morbidity ◽  
Control Group ◽  
Study Group ◽  
Control Groups ◽  
And Control

Background: Caesarean delivery (CD) rates in developing countries are rising beyond the recommended rates of World health organization. Objective of this study was to evaluate whether Dexamethasone injections reduce neonatal incubation admissions when given before scheduled caesarean delivery (CD) at term or not.Methods: A double blinded, two armed, randomized clinical trial was conducted at Tanta University hospitals in the period from October 2017 to March 2019. Four hundred pregnant women admitted for scheduled CD with gestational age ≥37 weeks were included. Patients were randomized into study group and control group. The study group was given 3 dexamethasone doses, 8 mg each while control group was given saline injections simultaneously as a placebo drug. The primary outcome was the neonatal incubatory admissions.Results: Demographic data in both groups were comparable. Transient tachypnea of newborn (TTN) was 15.47% in study group versus 20.33% in control group with p=0.227. The respiratory distress (RDS) in study group was 6.63% versus 9.89% in control group with p=0.260. The incubation admissions were nasal oxygen 12.71% versus 15.38%, continuous positive airway pressure ventilation (CPAP) 5.52% versus 8.24% and mechanical ventilation was 3.87% versus 6.59% in the study and control groups respectively.Conclusions: Although Dexamethasone administration before scheduled CD at term reduced both respiratory morbidity and incubation admissions, the differences between study and control groups were not significant.

Management of Aphthous Ulceration with Topical Quercetin: A Randomized Clinical Trial

2010 ◽  
Vol 11 (4) ◽  
pp. 9-16 ◽  
Author(s):  
Ahmed Abd El-Meguid Mostafa Hamdy ◽  
Mohamed Abd El-Moneam Ibrahem
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Topical Application ◽  
Size Difference ◽  
Control Group ◽  
Ulcer Size ◽  
Aphthous Ulcers ◽  
Aphthous Ulceration ◽  
Group 2 ◽  
Group 1

Abstract Aim Recurrent aphthous ulceration is the most commonly known oral mucosal disease. Quercetin is a useful therapeutic agent for the treatment of colitis and gastric ulcer. The objective of this study was to determine the effect of topical application of quercetin in the treatment of minor aphthous ulcers. Methods and Materials Forty male patients with no known pathology of the oral mucosa other than minor aphthous ulcers were enrolled in this study. Patients were randomly divided into two groups, each consisting of 20 patients. Group 1 (control group) patients used a benzydamine hydrochloride mouthwash three times daily. Group 2 patients placed two to three dabs of quercetin three times daily directly on their ulcers. Clinical evaluation of patients included assessment of ulcer size, pain measure, and interviews regarding the topical application of quercetin in terms of consistency, taste, local tolerability, and ease of application. Results The topical application of quercetin cream to minor mouth ulcers relieved pain and produced complete healing in seven of the Group 2 patients (35 percent) in 2–4 days, 18 patients (90 percent) in 4–7 days, and 20 patients (100 percent) in 7–10 days. When comparing the mean ulcer size after 10 days, lesions in the Group 2 patients were smaller than those in Group 1, and the size difference between the two groups was significantly different (p<0.004). Also, 90 percent of patients responded that they appreciated the ease of application when using the topical quercetin, and they did not object to its consistency or taste. Conclusion Quercetin is a safe, well-tolerated, and highly effective promising new, adjunctive treatment for healing common aphthous ulcers. Clinical Significance Although aphthous ulcers typically resolve on their own in one to two weeks, the daily topical application of quercetin may be useful in accelerating the healing process of minor aphthous ulcers. Citation Hamdy AAEM, Ibrahem MAE. Management of Aphthous Ulceration with Topical Quercetin: A Randomized Clinical Trial. J Contemp Dent Pract [Internet]. 2010 July; 11(4):009-016. Available from: http://www.thejcdp. com/journal/view/volume11-issue4-hamdy

scholarly journals Effects of nanomicelle curcumin capsules on prevention and treatment of oral mucosits in patients under chemotherapy with or without head and neck radiotherapy: a randomized clinical trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Seyed Javad Kia ◽  
Maryam Basirat ◽  
Hamid Saeidi Saedi ◽  
Seyed Ali Arab
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Head And Neck ◽  
Oral Mucositis ◽  
Control Group ◽  
Study Group ◽  
Link Type ◽  
Prevention And Treatment ◽  
And Control ◽  
Head And Neck Radiotherapy

Abstract Background One of the most prevalent complications of chemotherapy and radiotherapy is oral mucositis (OM) and manifests as erythema and ulceration. Curcumin is one of the components of turmeric and possesses anti-inflammatory and anti-oxidative features. Some of studies have proved the effectiveness of Curcumin in OM. This study aimed to investigate the effects of nanomicelle Curcumin on OM related chemotherapy and head and neck radiotherapy. Methods In this clinical trial study, 50 patients underwent chemotherapy with or without head and neck radiotherapy were divided into study and control group. The study group was received Curcumin nanomicelle capsules 80 mg twice a day and the control group took placebo two times a day for 7 weeks and the severity and pain of OM was measured. Results Oral mucositis severity in control group in the first (P = 0.010), fourth (P = 0.022) and seventh (P < 0.001) weeks were significantly more than the study group. Pain grade in study group was lower than control group only in the seventh week. (P = 0.001) Additionally, NRS incremental gradient in control group was more than study group. OM severity in patients who underwent only chemotherapy in the control group were significantly more than the study group in all weeks. In patients who were under chemotherapy and head and neck radiotherapy, OM in control group was significantly more intense than the study group only in the fourth and seventh weeks. Conclusions Nabomicelle Curcumin capsules is effective on prevention and treatment of head and neck radiotherapy and especially chemotherapy induced OM. Trial registration Registered 12 February 2019 at Iranian Registry of Clinical Trials (IRCT). IRCT code: IRCT20100101002950N6. https://en.irct.ir/trial/36665. GUMS ethical code: IR.Gums.Rec.1397.296.

scholarly journals The Efficiency Of Physics Forceps In Comparison To The Conventional Dental Extraction Forceps: A randomized Clinical Trial

2019 ◽  
Vol 31 (2) ◽  
pp. 52-59 ◽  
Author(s):  
Ali M Hasan
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Bone Fracture ◽  
Soft Tissues ◽  
Alveolar Bone ◽  
Extraction Procedure ◽  
Dental Extraction ◽  
Control Group ◽  
Study Group ◽  
Surgical Extraction

Background: Tooth extraction is one of the most commonly performed procedures in dentistry. It is usually a traumatic process often resulting in immediate destruction and loss of alveolar bone and surrounding soft tissues. Various instruments have been described to perform atraumatic extractions which can prevent damage to the paradental structures. The physics forceps is one of those innovations in dental extraction technologies that claim to provide an efficient means for atraumatic dental extractions. Materials and method: A randomized clinical trial was conducted to compare the physics forceps with the conventional forceps for the removal of 28 mandibular single rooted teeth under the following parameters: incidence of crown, root, buccal alveolar bone fracture, the incidence of gingival tear and time needed for extraction. The samples were assigned randomly into two groups according to the computer based randomization software, into a control group (A) and study group (B). The control group was subjected to the surgical extraction procedure using the conventional forceps while the study group was subjected to the surgical extraction procedure using the physics forceps. Results: results showed that the time required for extraction using the physics forceps was (mean 0.385 min.), which was significantly lesser as compared with that of conventional forceps (mean 3.971 min.) (P=0.011), buccal bone fracture occurred in 4 out of 14 cases (28.57%) using the conventional forceps while it did not occur with the use of the physics forceps (0.00%), crown fracture occurred in 3 cases using the conventional forceps (21.43%), while it did not occur with the use of the physics forceps (0.00%), root fracture occurred in 1 case using the physics forceps (3.57%), while it did not occur with the use of the conventional forceps (0.00%). As for the gingival tear, it occurred in 7 cases using the conventional forceps (50.00%), while it did not occur with the use of the physics forceps (0.00%) which was highly significant (P=0.006). Conclusions: the use of physics forceps maintains the integrity of gingiva and surrounding periodontium. So extractions using physics forceps are less invasive over conventional forceps and can be considered as a reliable method for extraction requiring significantly less comparative intraoperative time.

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