Efficacy of Technetium Scintigraphy as an investigative Tool in Papillary Carcinoma of Thyroid: A Prospective Study

2016 ◽  
Vol 7 (4) ◽  
pp. 220-222
Author(s):  
C Sreenivas ◽  
Vinay Raj ◽  
V Devipriya
Keyword(s):  
Prospective Study ◽  
Thyroid Nodule ◽  
Papillary Carcinoma ◽  
Thyroid Nodules ◽  
Care Providers ◽  
Investigative Tool ◽  
Thyroid Scan ◽  
Solitary Thyroid Nodule ◽  
A Prospective Study ◽  
Cold Nodule

ABSTRACT Introduction and background Thyromegaly is a common cause of physician consultation. Solitary thyroid nodules are conventionally viewed with suspicion. Clinical examination cannot reliably distinguish between a solitary thyroid nodule and a dominant nodule in multinodular goiter. Ultrasonographical examination has its own pitfalls. Technetium 99 is a commonly used modality for the functional assessment of solitary thyroid nodule detection. It has the advantage of low cost with lower radiation dose to the exposed patients. On literature search, studies on Technetium 99 scintigraphy for thyroid in context to the Indian scenario does not yield much information, and very few studies are notable. This study was conducted to correlate and qualify thyroid cold nodule as detected by technetium 99 pertechnetate thyroid scan. Objective This study was conducted to correlate, qualify, and compare the predictive value of technetium 99 pertechnetate scintigraphy on solitary thyroid nodule vis-à-vis fine needle aspiration cytology (FNAC) and to countercheck with histopathological examination (HPE). Materials and methods A prospective cohort study in a National Accreditation Board for Hospitals & Health care Providers, National Assessment and Accreditation Council, and Joint Commission International-accredited tertiary care teaching university hospital was conducted over a period of 36 months. All the subjects underwent clinical assessment of the neck that included standard examination techniques to segregate solitary thyroid nodules. They were then subjected to technetium 99 pertechnetate scintigraphy using the standard protocol. All the patients with solitary cold nodule underwent FNAC followed by nodule excision or hemi-thyroidectomy under general anesthesia. All the specimens underwent HPE by an experienced histopathologist. The results were statistically analyzed using Pearson's chi-square test. Results (1) Cold nodules as detected by technetium 99 pertechnetate thyroid scan is a reasonable indicator of probable malignancy vis-à-vis FNAC. (2) Occurrence of cold nodules is highest in third to fifth decade of life (21- to 50-year age group). (3) Occurrence of cold nodules is higher in females (83%), whereas occurrence of malignancy in cold nodules is higher in males (85%). (4) Occurrence of malignancy in cold nodules is higher in subjects less than 21 and above 50 years. (5) Technetium 99m pertechnetate thyroid scintigraphy is an important preoperative tool in management of thyroid nodules, and its routine use in all such patients is recommended, especially to rule out cold nodules. How to cite this article Mohanty S, Sreenivas C, Raj V, Efficacy of Technetium Scintigraphy as an investigative Tool in Papillary Carcinoma of Thyroid: A Prospective Study. Int J Head Neck Surg 2016;7(4):220-222.

scholarly journals Predicting Malignancy in a Solitary Thyroid Nodule: A Prospective Study on the Role of Color Doppler Ultrasonography

2014 ◽  
Vol 6 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Ravi Varma ◽  
Gururaja Rao ◽  
Shilpa Rao ◽  
Nikhil M Bhagwat ◽  
Manoj D Chadha ◽  
...  
Keyword(s):  
Prospective Study ◽  
Thyroid Nodule ◽  
Doppler Ultrasonography ◽  
Thyroid Nodules ◽  
Color Doppler ◽  
Color Doppler Ultrasonography ◽  
Solitary Thyroid Nodule ◽  
A Prospective Study ◽  
Central Flow

ABSTRACT Palpable thyroid nodules are fairly common. While many are benign, the clinician faces the challenge of detecting the 4 to 14% of malignant lesions. Fine needle aspiration cytology (FNAC) of thyroid nodules seems to have eclipsed all other techniques for diagnosis of thyroid cancer, but has its limitations when a nodule is inaccessible or in the case of follicular neoplasm. This study from a hospital from Indian west coast shows that vascular flow pattern of extensive peripheral and central flow (Type-3) or a central flow only (Type-4) and a resistive index (RI) of >0.75 on power Doppler sonography shows a healthy sensitivity and excellent specificity for predicting malignancy. The utility becomes even more apparent among follicular neoplasms where FNAC can offer little help in distinguishing malignancy. How to cite this article Rao G, Rao S, Varma R, Bhagwat NM, Chadha MD, Joshi AS, Varthakavi PK. Predicting Malignancy in a Solitary Thyroid Nodule: A Prospective Study on the Role of Color Doppler Ultrasonography. Int J Otorhinolaryngol Clin 2014;6(1):9-14.

scholarly journals Technetium scintigraphy as a predictive tool of thyroid malignancy

2017 ◽  
Vol 3 (2) ◽  
pp. 308
Author(s):  
Sanjeev Mohanty ◽  
Sreenivas . ◽  
Vinay Raj T. ◽  
Devipriya . ◽  
Vinoth M.
Keyword(s):  
Thyroid Nodule ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Solitary Thyroid Nodule ◽  
Needle Aspiration Cytology ◽  
Cold Nodule

<p class="abstract" style="display: inline !important;"><strong>Background:</strong> Thyromegaly is a common cause of physician consultation. Solitary thyroid nodules are conventionally viewed with suspicion. Clinical examination cannot reliably distinguish between a solitary thyroid nodule and a dominant nodule in multinodular goiter. Ultrasonographical examination has its own pitfalls. Technetium 99 is a commonly used modality for the functional assessment of solitary thyroid nodule detection. It has the advantage of low cost with lower radiation dose to the exposed patients. On literature search, studies on technetium 99 scintigraphy for thyroid in context to the Indian scenario do not yield much information and very few studies are notable. This study was conducted to correlate and qualify thyroid cold nodule as detected by Technetium 99 pertechnetate thyroid scan. <span lang="EN-IN">This study was conducted to correlate, qualify and compare the predictive value of Technetium 99 pertechnetate scintigraphy on solitary thyroid nodule via fine needle aspiration cytology and to countercheck with histopathological examination. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">A prospective cohort study in a NABH, NAAC and JCI accredited tertiary care teaching university hospital was conducted over a period of 36 months. All the subjects underwent clinical assessment of the neck included standard examination techniques to segregate solitary thyroid nodules. They were then subjected to Technetium 99 pertechnate scintigraphy using the standard protocol. All the patients with solitary cold nodule underwent FNAC followed by nodule excision or hemi-thyroidectomy under general anaesthesia. All the specimens underwent histo-pathological examination by an experienced histopathologist. The results were statistically analysed using pearson chi-square test.  </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Cold nodules as detected by Technetium 99 pertechnetate thyroid scan is a reasonable indicator of probable malignancy via fine needle aspiration cytology. Occurrence of cold nodules is highest in 3<sup>rd</sup> to 5<sup>th</sup> decade of life (21-50 year age group). Occurrence of cold nodules is higher in females (83%) whereas occurrence of malignancy in cold nodules is higher in males (85%). Occurrence of malignancy in cold nodules is higher in subjects less than 21 and above 50 years. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Technetium 99m pertechnetate thyroid scintigraphy is an important preoperative tool in management of thyroid nodules and its routine use in all such patients is recommended especially to rule out cold nodules.</span></p>

scholarly journals A clinical study of incidence of malignancy in solitary thyroid nodule in a tertiary care hospital

2018 ◽  
Vol 6 (1) ◽  
pp. 293
Author(s):  
Palani V. ◽  
Reshma S.
Keyword(s):  
Thyroid Nodule ◽  
Thyroid Nodules ◽  
Tertiary Care ◽  
Care Hospital ◽  
Solitary Nodule ◽  
Medical College ◽  
Solitary Thyroid Nodule ◽  
The Mean ◽  
A Prospective Study ◽  
Optimum Management

Background: Thyroid nodules are common endocrine problem. A discrete swelling in an otherwise impalpable gland is termed as solitary nodule of thyroid. Solitary nodules have a high likelihood of being malignant. They should be characterized properly for optimum management. Aim of the study is to identify the incidence of malignancy in solitary nodule thyroid.Methods: A prospective study had been carried out from January 2018 to October 2018, in the Department of General surgery, ACS Medical College and Hospital, Chennai, India. Fifty patients, who presented with solitary thyroid swelling were examined clinically and confirmed after taking a detailed history and underwent thyroid surgery were included in this study. The histopathological reports were evaluated by standard statistical methods.Results: There were 50 cases of clinically detected solitary thyroid nodule with female preponderance more than males. The mean age of the incidence of solitary thyroid nodule is 35years. The incidence of malignancy in solitary thyroid nodule is 20%.Conclusions: It is concluded from the present study that 20% of solitary thyroid nodules are malignant, with female preponderance and a mean age of solitary thyroid nodule is 35years.

scholarly journals Histopathological study of solitary nodules of thyroid

1970 ◽  
Vol 6 (4) ◽  
pp. 486-490 ◽  
Author(s):  
UN Khadilkar ◽  
P Maji
Keyword(s):  
Thyroid Nodule ◽  
Papillary Carcinoma ◽  
Thyroid Nodules ◽  
Medullary Carcinoma ◽  
Histopathological Study ◽  
Malignant Neoplasms ◽  
Solitary Nodule ◽  
Solitary Thyroid Nodule ◽  
Neoplastic Lesions ◽  
Microscopic Features

Objective: To determine the incidence of various thyroid disorders manifesting as Solitary Thyroid Nodule and also to evaluate the histomorphology of the lesions. Materials and methods: Hundred specimens of Solitary Thyroid Nodules were studied for gross characteristics, microscopic features, age and sex incidence. Results: Of the 100 cases of Solitary Thyroid Nodules, 66% were non neoplastic and 34% were neoplastic. Among the neoplasms, 21% were malignant and 13% were benign. The age incidence ranged from 20-50 years for non neoplastic lesions and 20-40 years for neoplasms. A female preponderance was seen for both non neoplastic and neoplastic conditions. The solitary nodules involved the right side of the thyroid more commonly than the left. Involutional colloid nodule was the predominant type of solitary nodule (52%). Among the malignant neoplasms, papillary carcinoma was the commonest solitary nodule (13%). One case each of hyalinising trabecular adenoma, columnar cell variant of papillary carcinoma and medullary carcinoma unusually presenting as solitary nodules were encountered in the present study. Conclusion: Histomorphologic evaluation of Solitary Thyroid Nodules presenting without a background setting of multinodular goiter is challenging and mandatory as the diagnoses ranges from the common non neoplastic lesions like involuting nodules to the rare neoplastic conditions like medullary carcinoma. Key words: Solitary Thyroid Nodule morphology, involuting nodule, medullary carcinoma doi: 10.3126/kumj.v6i4.1740   Kathmandu University Medical Journal (2008), Vol. 6, No. 4, Issue 24, 486-490

A prospective study of thyroid ultrasound scan in the clinically solitary thyroid nodule

1985 ◽  
Vol 58 (691) ◽  
pp. 617-619 ◽  
Author(s):  
J. Walker ◽  
D. Findlay ◽  
S. S. Amar ◽  
P. G. Small ◽  
M. L. Wastie ◽  
...  
Keyword(s):  
Prospective Study ◽  
Thyroid Nodule ◽  
Ultrasound Scan ◽  
Thyroid Ultrasound ◽  
Solitary Thyroid Nodule ◽  
A Prospective Study

Solitary thyroid nodules and malignancy: A prospective study

2019 ◽  
Vol 11 (3) ◽  
pp. 67-72
Author(s):  
Shivkumar . ◽  
◽  
Deepak Saharan ◽  
Suresh . ◽  
◽  
...  
Keyword(s):  
Prospective Study ◽  
Thyroid Nodules ◽  
A Prospective Study

scholarly journals Acute benign myositis of childhood: Results of a prospective study performed in a pediatric emergency department

2020 ◽  
Vol 10 (3) ◽  
Author(s):  
Vanuza Rosa ◽  
Gabriela Kuzma ◽  
Luana Hornung ◽  
Márcia Bandeira
Keyword(s):  
Emergency Department ◽  
Prospective Study ◽  
Pediatric Emergency ◽  
Pediatric Emergency Department ◽  
Care Providers ◽  
Study Objective ◽  
Gait Abnormality ◽  
The Mean ◽  
A Prospective Study ◽  
Musculoskeletal Involvement

OBJECTIVE: Benign acute childhood myositis is characterized by acute musculoskeletal involvement leading to transient limitations on deambulation followed by a viral illness. Our study objective to evaluate clinical and laboratory features of patients in a pediatric emergency department. METHODOS: We conducted a prospective study in patients with symptoms and laboratory findings compatible with viral myositis in the period of August 2017 to August 2018. RESULTS: We assessed 20 patients in the period of twelve months. The mean age was 8,25 years. Of these, 83,3% had infectious symptoms in the week before the musculoskeletal involvement. By the time of the diagnosis, the symptoms were: calf pain, reluctance to walk, gait abnormality, diffuse myalgia and calf weakness. The most relevant laboratory finding was the elevation of CPK (mean 3359,556U/L) level, followed by AST (mean 131U/L) and ALT (mean 64,66U/L) elevation. The mean time for symptom relief was 3 days and in 7 days all exams were normal. CONCLUSION: Though the exact incidence of this condition remains undetermined, the lower extremity pain and the gait abnormality is of concern of both parents and health care providers. We emphasize the importance of knowing this condition to avoid unnecessary exams and the delay in the diagnosis of severe conditions.

scholarly journals Ultrasonography Classification of the American Thyroid Association for Predicting Malignancy in Thyroid Nodules >1cm with Indeterminate Cytology: A Prospective Study

2018 ◽  
Vol 50 (08) ◽  
pp. 597-601 ◽  
Author(s):  
Tiara Rocha ◽  
Pedro Rosario ◽  
Alexandre Silva ◽  
Maurício Nunes ◽  
Tulio Silva ◽  
...  
Keyword(s):  
Prospective Study ◽  
Thyroid Nodules ◽  
Thyroid Neoplasms ◽  
Needle Aspiration ◽  
American Thyroid Association ◽  
Molecular Tests ◽  
Indeterminate Cytology ◽  
A Prospective Study ◽  
Doppler Analysis

AbstractThe objective of this prospective study was to evaluate the ultrasonography classification of the American Thyroid Association (ATA) for predicting malignancy in thyroid nodules >1 cm with indication for fine-needle aspiration (FNA) whose cytology was indeterminate. Additionally, the combination of the ATA classification with Doppler analysis was evaluated. All patients with thyroid nodules >1 cm were eligible. Each nodule was assigned to one of the ATA categories. Exclusively or predominantly intranodular vascularity was considered suspicious. One hundred and thirty-seven patients with 143 nodules underwent FNA and those with indeterminate cytology (Bethesda category III or IV) were selected. All patients were referred for surgery. Among the 143 nodules evaluated, 92 were benign, 33 were malignant, 13 were noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), and 5 were tumors of uncertain malignant potential (TUMP). The rate of malignancy, including NIFTP and TUMP in this definition, was 80%, 42.8%, 13%, 10%, and 23% for nodules with a high suspicion, intermediate suspicion, low suspicion, very low suspicion, and undefined ultrasonographic pattern, respectively. Considering NIFPT and TUMP as benign, these rates were 72%, 22.4%, 4.3%, 0%, and 15.4%, respectively. The addition of Doppler analysis did not significantly improve the prediction of malignancy obtained with the ATA classification alone. The results of this prospective study show the usefulness of the ATA ultrasonographic classification for predicting malignancy specifically in thyroid nodules >1 cm with indeterminate cytology. The ATA category of the nodule should influence the decision for follow-up, molecular tests, or surgery.

Cushing's syndrome and autonomous thyroid nodules, a variant of multiple endocrine neoplasia?

1986 ◽  
Vol 113 (3) ◽  
pp. 463-464 ◽  
Author(s):  
C. G. Semple ◽  
J. A. Thomson
Keyword(s):  
Thyroid Nodule ◽  
Cushing’S Syndrome ◽  
Multiple Endocrine Neoplasia ◽  
Thyroid Nodules ◽  
Cushing Syndrome ◽  
Cushing's Syndrome ◽  
Graves Disease ◽  
Endocrine Neoplasia ◽  
Solitary Thyroid Nodule ◽  
Autonomous Thyroid Nodule

Abstract. Over a 20 year period 4 of 40 (10%) female patients with Cushing' syndrome also had a solitary thyroid nodule. In 3 cases this was an autonomous 'hot' nodule. In the same population only one case of presumed Graves' disease was seen. It is postulated that the association of autonomous thyroid nodule and Cushing's syndrome may represent a variant of multiple endocrine neoplasia.

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