scholarly journals Intravenous Iron Therapy versus Oral Iron in Postpartum Patients in Rural Area

2011 ◽  
Vol 3 (2) ◽  
pp. 67-70 ◽  
Author(s):  
SA Inamdar ◽  
Sunayana Verma
Keyword(s):  
Rural Area ◽  
Ferrous Sulphate ◽  
Intravenous Iron ◽  
Oral Route ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Iron Therapy ◽  
Iron Treatment ◽  
Intravenous Iron Therapy ◽  
The Impact

ABSTRACT Objectives The aim of this study is to evaluate the efficiency and safety of intravenous iron sucrose complex and comparison with oral iron therapy in postpartum period in rural area. Materials and methods It is a prospective, randomized, hospital-based clinical study carried out in over 150 patients, having Hb < 8 mg/dl after 24 hours of delivery. 600 to 800 mg iron sucrose has been given in divided doses, 200 mg on alternate day in 100 ml of normal saline to half of the patients whereas rest of the patients given 200 mg bd dose of ferrous sulphate by oral route for one month. Data was collected after 1st, 2nd, 3rd and 4th week for the hemoglobin estimation and assessment of the impact of intravenous iron sucrose treatment on the postpartum parameters. Results The mean Hb was significantly increased in the intravenous iron sucrose group in 7 days (7.42 ± 1.04 gm/dl to 9.8 ± 0.76 gm/dl) of treatment but there was no change observed in mean Hb in the patients treated with oral ferrous sulphate. Women treated with intravenous iron sucrose has shown significantly higher Hb on day 7, day 15 and day 30 as compared to the women those were treated with oral iron (p < 0.0001). Conclusion Overall intravenous iron sucrose appears to be an effective mode of treatment in postpartum patients with no serious side effects and associated with faster recovery in shorter duration of hospital stay than oral iron treatment.

scholarly journals Oral and Intravenous Iron Therapy Differentially Alter the On- and Off-Tumor Microbiota in Anemic Colorectal Cancer Patients

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1341
Author(s):  
Oliver Phipps ◽  
Hafid O. Al-Hassi ◽  
Mohammed N. Quraishi ◽  
Edward A. Dickson ◽  
Jonathan Segal ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ferrous Sulphate ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Therapy ◽  
Deficiency Anemia ◽  
Ferric Carboxymaltose ◽  
Β Diversity ◽  
Post Surgery ◽  
Intravenous Iron Therapy

Iron deficiency anemia is a common complication of colorectal cancer and may require iron therapy. Oral iron can increase the iron available to gut bacteria and may alter the colonic microbiota. We performed an intervention study to compare oral and intravenous iron therapy on the colonic tumor-associated (on-tumor) and paired non-tumor-associated adjacent (off-tumor) microbiota. Anemic patients with colorectal adenocarcinoma received either oral ferrous sulphate (n = 16) or intravenous ferric carboxymaltose (n = 24). On- and off-tumor biopsies were obtained post-surgery and microbial profiling was performed using 16S ribosomal RNA analysis. Off-tumor α- and β-diversity were significantly different between iron treatment groups. No differences in on-tumor diversity were observed. Off-tumor microbiota of oral iron-treated patients showed higher abundances of the orders Clostridiales, Cytophagales, and Anaeroplasmatales compared to intravenous iron-treated patients. The on-tumor microbiota was enriched with the orders Lactobacillales and Alteromonadales in the oral and intravenous iron groups, respectively. The on- and off-tumor microbiota associated with intravenous iron-treated patients infers increased abundances of enzymes involved in iron sequestration and anti-inflammatory/oncogenic metabolite production, compared to oral iron-treated patients. Collectively, this suggests that intravenous iron may be a more appropriate therapy to limit adverse microbial outcomes compared to oral iron.

scholarly journals Oral and Intravenous Iron Therapy Differentially Alter The on- and Off-Tumour Microbiota in Anaemic Colorectal Cancer Patients.

2021 ◽  
Author(s):  
Oliver Phipps ◽  
Hafid Omar Al-Hassi ◽  
Mohammed Nabil Quraishi ◽  
Edward A Dickson ◽  
Jonathan Segal ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ferrous Sulphate ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Therapy ◽  
Ferric Carboxymaltose ◽  
Large Shift ◽  
Post Surgery ◽  
Anti Inflammatory ◽  
Intravenous Iron Therapy

Abstract Background Iron deficiency anaemia is a common complication of colorectal cancer and may require iron therapy. Oral iron can increase iron available to gut bacteria and may alter the colonic microbiota. We performed an intervention study to compare oral and intravenous iron therapy on the colonic tumour-associated (on-tumour) and paired non-tumour-associated adjacent (off-tumour) microbiota. Anaemic patients with colorectal adenocarcinoma received either oral ferrous sulphate (n=16) or intravenous ferric carboxymaltose (n=24). On- and off-tumour biopsies were obtained post-surgery and microbial profiling was performed using 16S ribosomal RNA analysis.Results Off-tumour α- and β-diversity were significantly different between iron treatment groups. No differences in on-tumour diversity were observed. Off-tumour microbiota of oral iron-treated patients shows higher abundances of the orders Clostridiales, Cytophagales and Anaeroplasmatales compared to intravenous iron-treated patients. The on-tumour microbiota was enriched with the orders Lactobacillales and Alteromonadales in the oral and intravenous iron groups, respectively. The on- and off-tumour microbiota associated with intravenous iron-treated patients infers increased abundances of enzymes involved in iron sequestration and anti-inflammatory/oncogenic metabolite production, compared to oral iron-treated patients. Paired on- and off-tumour microbiota show large taxonomic differences in intravenous iron-treated patients and limited differences in oral iron-treated patients.Conclusion Oral iron shows a large shift in the off-tumour microbiota, but a more limited change in on-tumour microbiota. The on- and off-tumour microbiota in intravenous iron-treated patients infers a microbiota associated with anti-inflammatory and tumour protective pathways. Suggesting intravenous iron may be a more appropriate therapy to limit adverse microbial outcomes, compared to oral iron.Trial registration: NCT01701310. Registered 21 March 2012, https://clinicaltrials.gov/ct2/show/NCT01701310

scholarly journals Can oral iron tablets be replaced by the intravenous iron sucrose in antenatal period? A new thought.

2018 ◽  
Vol 7 (8) ◽  
pp. 3103
Author(s):  
Snehal S. Tate ◽  
Arti S. Shirsath ◽  
Neelesh S. Risbud
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Iron Therapy ◽  
Deficiency Anaemia ◽  
Significant Difference ◽  
Oral Group ◽  
Intravenous Iron Therapy

Background: Anaemia is the commonest medical disorder that contributes significantly to maternal morbidity and mortality, preterm delivery, intrauterine growth restriction. Pregnant women are particularly vulnerable to anaemia because they have dual iron requirements both for their growth and growth of foetus. A high proportion of women in both industrialized and developing countries become anaemic during pregnancy. Intravenous iron therapy is safe convenient and effective than oral iron therapy in prevention of iron deficiency anaemia when compliance is the problem. The aim of this study is to compare the efficacy, safety and acceptability of intravenous iron Vs oral iron in prevention of iron deficiency anaemia during pregnancy. The objective of the present research was to study the efficacy, safety and acceptability of oral iron (ferrous fumarate) versus intravenous iron (iron sucrose) for the prevention of iron deficiency anaemia during pregnancy.Methods: It was a prospective comparative case control study without blinding including 400 registered antenatal women in SKNMC and GH, Narhe, Pune. Results were based on collection and analysis of data from samples within study population.Results: There was no significant difference in mean haemoglobin rise between oral group and IV group but there is significant difference between mean ferritin levels between oral group and IV group. In IV group ferritin levels at 36 weeks were almost 1.8 times more than oral group. Acceptability and convenience of IV iron was significantly more than oral iron.Conclusions: Intravenous iron therapy in the form of three divided doses, one in each trimester can be safely used in the antenatal woman as an alternative to prophylactic iron tablets for prevention of iron deficiency anaemia especially in women who are non-compliant or does not tolerate oral iron tablets.

Intravenous Iron Sucrose

2017 ◽  
Vol 1 (1) ◽  
pp. 20-22
Author(s):  
KS Kavitha Gautham
Keyword(s):  
Iron Deficiency ◽  
Health Problem ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Current Understanding ◽  
Iron Therapy ◽  
Iron Supplement ◽  
Iv Iron

ABSTRACT Iron deficiency is a major worldwide health problem. There is recent evidence that anemia is the last manifestation of the syndrome. Advances in outlining the physiology of iron deficiency have been made; gaps remain in the current understanding. While oral iron supplement remains the mainstay, some indications for intravenous (IV) administration have developed. In this review, we will highlight the indications and prerequisites of IV iron therapy, dosage, safety, and method of administration. How to cite this article Gautham KSK. Intravenous Iron Sucrose. World J Anemia 2017;1(1):20-22.

Intravenous iron sucrose for children with iron deficiency failing to respond to oral iron therapy

2012 ◽  
Vol 58 (4) ◽  
pp. 655-655
Author(s):  
Shelley E. Crary ◽  
Katherine Hall ◽  
George R. Buchanan
Keyword(s):  
Iron Deficiency ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Iron Therapy ◽  
Oral Iron Therapy

scholarly journals A study on management of maternal anemia with infusion of intravenous iron sucrose and its outcome in management of anemia

2018 ◽  
Vol 8 (1) ◽  
pp. 39
Author(s):  
Uma Maheswari R. ◽  
R. Veerakumaran
Keyword(s):  
Side Effects ◽  
Pregnant Women ◽  
Hematological Parameters ◽  
Intravenous Iron ◽  
Hemoglobin Level ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Iron Therapy ◽  
Iron Group ◽  
Moderate Anemia

Background: In India, women become pregnant with low baseline hemoglobin level resulting in high incidence of moderate to severe anemia in pregnancy where oral iron therapy cannot meet the requirement. Pregnant women with moderate anemia are to be treated with parenteral iron therapy. The aim of the study is to the infusion of intravenous iron sucrose and its outcome in the management of anemia.Methods: Totally 100 pregnant females were included in the study. The study period was from January 2018-July 2018 at vanavil medical center in Chennai. 50 Patients of Group A was given oral iron tablets containing100mg of elemental iron. 50 patients of Group B was given a total of 1000 mg of intravenous iron sucrose divided into five doses of 200 mg each at weekly intervals. Estimation of hemoglobin was started 4 weeks after commencement of iron therapy and then repeated every 4 weeks till 36 weeks of gestation, pre-delivery and postpartum.Results: Target hemoglobin levels were achieved in 4 weeks’ time in 19 (76%) patients in the iron sucrose group as compared to 08 (32%) of patients in the oral iron group. There was a significant improvement in the various hematological parameters in iv sucrose group as compared to patients in the oral iron group. There were no significant allergic reactions in iv sucrose group.Conclusions: Our results showed that intravenous iron sucrose therapy was effective to treat moderate anemia in pregnant women. Intramuscular preparations are known to be associated with local side-effects. Iron sucrose complex iv therapy was with negligible side effects. It caused a rapid rise in hemoglobin level and the replacement of stores was faster. Long term comparative studies are required to assess if they can be used at a peripheral level.

scholarly journals Use of Iron Sucrose Complex in Treatment of Anemia in Pregnancy

2013 ◽  
Vol 25 (1) ◽  
pp. 20-23 ◽  
Author(s):  
Rabeya Akther ◽  
Hasina Afroj
Keyword(s):  
Hemoglobin Concentration ◽  
Intravenous Iron ◽  
Hemoglobin Level ◽  
Iron Sucrose ◽  
Iron Therapy ◽  
Deficiency Anemia ◽  
Prospective Clinical Study ◽  
Anemia In Pregnancy ◽  
Intravenous Iron Therapy ◽  
In Pregnancy

Objective: To demonstrate the value of iron sucrose complex in the treatment of anemia in  pregnancy.Methods: It is a prospective clinical study, of 35 consecutive pregnant women suffering from  anemia in pregnancy. The study was conducted over a period of twelve months. Hemoglobin  concentration was measured three times during pregnancy. All women consumed timed release iron from 17 weeks onward up to birth of the baby. If hemoglobin level is (8.5 - 9) gm/dl, parentral Iron sucrose complex 2 doses (400gm of iron) were given intravenously and hemoglobin  level was checked after 15 days.Results: There were 35 women who completed the treatment and data was available for  analysis. Their mean age was 27.5(range21-35) years. Fifty six percent were 2nd gravid. Twenty eight (28%) percent women in 1st half of pregnancy, 53% in 2nd trimester and 16% in 3rd trimester suffering from moderate anemia and treated with iron sucrose complex (ISC). The average Hemoglobin concentration before treatment was 8.47gm/dl and after treatment  was 9.67gm/dl. There was a statistically significant improvement in hemoglobin concentration. Three women developed side effects and did not get 2nd dose.Conclusion: Intravenous iron therapy is safe, convenient and effective in treatment of iron  deficiency anemia during pregnancy. The intravenous iron therapy can replace blood transfusion in antenatal period in many patients. DOI: http://dx.doi.org/10.3329/bjog.v25i1.13728 Bangladesh J Obstet Gynaecol, 2010; Vol. 25(1) : 20-23  

scholarly journals Intravenous iron sucrose for children with iron deficiency failing to respond to oral iron therapy

2010 ◽  
Vol 56 (4) ◽  
pp. 615-619 ◽  
Author(s):  
Shelley E. Crary ◽  
Katherine Hall ◽  
George R. Buchanan
Keyword(s):  
Iron Deficiency ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Iron Therapy ◽  
Oral Iron Therapy

scholarly journals A comparative study of oral iron and intravenous iron in iron deficient antenatal mothers

2018 ◽  
Vol 7 (5) ◽  
pp. 1848
Author(s):  
Suganya G. ◽  
D. Vimala
Keyword(s):  
Pregnant Women ◽  
Carbonyl Iron ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Iron Therapy ◽  
Oral Iron Therapy ◽  
Iron Deficient ◽  
Group A ◽  
Group B

Background: The aim of the study is to compare the efficacy, tolerance and compliance between oral iron and intravenous infusion of iron in iron deficient antenatal mother.Methods: This is a prospective randomised clinical and interventional study in the department of Obstetrics and Gynaecology in Vinayaka Mission Kirupananda Variyar Medical College and Hospital. The antenatal women attending the antenatal op were screened for Hb status. Those antenatal women of gestational age 16-34 weeks with Hb level between 7-10g% and diagnosed to have iron deficiency anemia by peripheral smear and serum ferritin were included in this study after getting informed consent. The total numbers of 100 mothers were allotted into two major groups, group A and group B of 50 subjects each. Group A: 50 pregnant women given oral iron supplementation (carbonyl iron 100 mg twice a day). Group B: 50 pregnant women given intravenous iron sucrose therapy after calculating the total iron requirement. The rise in hemoglobin in both the groups were comparedResults: In this study the mean rise of hemoglobin in carbonyl iron was 0.914±0.20 gm% whereas in iron sucrose group was 2.43±0.20gm%. This showed that iron sucrose (i.v) had better rise in Hb than carbonyl iron (oral).Conclusions: The present study revealed that intravenous iron sucrose therapy was bettertolerated with higher increase in mean haemoglobin compared to oral iron therapy. There were no serious side effects with intravenous iron sucrose therapy. Intravenous iron sucrose is a good substitute to oral iron therapy in moderate anaemia.

scholarly journals Comparative study of oral iron (ferrous sulphate) versus intravenous (iron sucrose) therapy in treating iron deficiency anaemia in puerperium

2018 ◽  
Vol 7 (9) ◽  
pp. 3653
Author(s):  
Soniya Vishwakarma ◽  
Rajani Rawat ◽  
Pragati Dwivedi ◽  
Vaibhav Kanti
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Iron Deficiency Anaemia ◽  
Ferrous Sulphate ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Deficiency Anaemia ◽  
Group I ◽  
Group Ii

Background: Iron deficiency anaemia is one of the major morbidities during post-partum period. The aim of this study was to compare the efficacy, safety and compliance of intravenous iron sucrose complex with oral Iron therapy in treatment of postpartum anemia.Methods: 100 postpartum anaemic patients randomized into two groups. In Group I oral iron ferrous sulphate tablets twice daily and in group II 200 mg of iron sucrose on every alternate day up to total calculated dose for 6 weeks. Hemoglobin and serum ferritin were measured on day 0, 2 week and 6 weeks. The side effects in both groups were noted.Results: Majority of patients are multiparous, illiterate and belonged to low socioeconomic. Mean baseline hemoglobin in oral group (Group I) was 7.90±0.905 gm /dl and in i/v group (Group II) was 7.81±0.849 gm /dl. There was significant rise in hemoglobin and hematocrit in both groups after 2 weeks and 6 weeks. However, efficiency of iron sucrose was greater in between the groups (p value=0.0000). There was a rise in serum ferritin to 58.35±14.537μg/L from 8.30±1,461μg/L after 6 weeks in intravenous group with shorter duration of treatment indicating a high efficacy (p<0.001). Intravenous iron sucrose did not result in any serious adverse reactions.Conclusions: This study illustrates clearly that intravenous iron sucrose complex is safe, convenient and effective in postpartum anemic women as compared with oral ferrous sulphate.

Sign in / Sign up

Export Citation Format

Share Document