Examination of D-dimer, FDP and TAT Levels After Total Knee Arthroplasty

2003 ◽  
Vol 52 (3) ◽  
pp. 489-492
Author(s):  
Manabu Yamamoto ◽  
Tatsuhiko Miyamoto ◽  
Seiji Sumiura ◽  
Kimio Nibu
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Total Knee ◽  
D Dimer

Disease-specific screening for deep venous thrombosis and pulmonary thromboembolism using plasma d-dimer values after total knee arthroplasty

2008 ◽  
Vol 18 (4) ◽  
pp. 359-365 ◽  
Author(s):  
Teruhito Yoshitaka ◽  
Nobuhiro Abe ◽  
Hiroshi Minagawa ◽  
Hirokazu Date ◽  
Yoshimasa Sakoma ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Knee Arthroplasty ◽  
Pulmonary Thromboembolism ◽  
Total Knee ◽  
Disease Specific ◽  
D Dimer

Risk of Venous Thromboembolism after Total Knee Arthroplasty in Patients with Rheumatoid Arthritis

2015 ◽  
Vol 42 (6) ◽  
pp. 928-934 ◽  
Author(s):  
Masahiro Izumi ◽  
Kiyoshi Migita ◽  
Mashio Nakamura ◽  
Yuka Jiuchi ◽  
Tatsuya Sakai ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Total Knee Arthroplasty ◽  
Venous Thromboembolism ◽  
Knee Arthroplasty ◽  
Demographic Data ◽  
Japanese Patients ◽  
Study Cohort ◽  
Vein Thrombosis ◽  
Total Knee ◽  
D Dimer

Objective.To compare the incidence of venous thromboembolism (VTE) following total knee arthroplasty (TKA) between patients with rheumatoid arthritis (RA) and those with osteoarthritis (OA).Methods.The subjects were composed of 1084 Japanese patients with OA and 204 with RA. Primary effectiveness outcomes were any deep vein thrombosis (DVT) as detected by bilateral ultrasonography up to postoperative Day 10 (POD10) and pulmonary embolism (PE) up to POD28. The main safety outcomes were bleeding and death from any cause up to POD28. Plasma D-dimer levels were measured before and at POD10 after TKA.Results.The study cohort was composed of 1288 patients from 34 hospitals. There was no death up to POD28. PE occurred in 2 patients with OA and in no patients with RA. The incidence of primary effectiveness outcome was 24.3% and 24.0% in patients with OA and RA, respectively. The incidence of major bleeding up to POD28 was 1.3% and 0.5% in patients with OA and RA, respectively. No differences in the incidence of VTE (symptomatic/asymptomatic DVT plus PE) or bleeding were noted between patients with RA and OA. D-dimer levels on POD10 were significantly higher in patients with OA compared with those with RA. Also, D-dimer levels on POD10 were significantly lower in patients receiving fondaparinux than in patients without pharmacological prophylaxis.Conclusion.Despite some differences in demographic data, patients with RA and OA have equivalent risks of VTE and bleeding following TKA.

scholarly journals Tranexamic Acid Combined with Compression Bandage Following Total Knee Arthroplasty Promotes Blood Coagulation: A Retrospective Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Guo-hua Li ◽  
Li-ming Ding ◽  
Lei Sun ◽  
Fu Wang
Keyword(s):  
Total Knee Arthroplasty ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
International Normalized Ratio ◽  
Control Group ◽  
Thrombin Time ◽  
Compression Bandage ◽  
Observation Group ◽  
Total Knee ◽  
D Dimer

Objective. This paper included a retrospective review of the effect of tranexamic acid (TXA) combined with pressure bandaging on hemostasis of patients who received a unilateral total knee arthroplasty (TKA) from 2017 to 2019. Methods. A total of 197 patients undergoing TKA were chosen to be classified into 2 groups, the compression bandage control group and compression bandage combined with TXA observation group. The patients received blood routine examination when they were in the 1st, 3rd, and 6th days of before and postoperation. Some parameters, such as hemoglobin (Hb), C-reactive protein (CRP), D-dimer value, fibrinogen, prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), international normalized ratio (INR), and erythrocyte sedimentation rate (ESR), were also investigated. Results. In our research, the mean age was 66.54 ± 7.95 years. No difference was found in patient sex ( P = 0.876 ) and age ( P = 0.749 ) between groups. No differences were found in the levels of Hb, fibrinogen, TT, and INR between the 2 groups at each period ( P > 0.05 ). The difference of PT was significantly different on the 1st day ( P = 0.011 ), 3rd day ( P = 0.010 ), and 6th day ( P = 0.004 ) after surgery. Besides, the changes in APTT in observation group were clearly higher compared with the control group on the 3rd day ( P = 0.001 ) and 6th day ( P = 0.001 ). On the 3rd and 6th days after operation, the CRP level of the two groups increased continuously, and the CRP level was significantly higher in the observation group in comparison with the control group ( P = 0.008 , P = 0.010 ). On 1st and 3rd days after surgery, compared to the control group, the D-dimer level of patients in the observation group was distinctly fewer ( P = 0.001 , P = 0.027 ). Conclusion. TXA combined with compression bandage is a potential option for the reduction of bleeding after TKA.

scholarly journals Significance of Measurement of D-dimer as Method of Screening for Venous Thromboembolism in Total Knee Arthroplasty

2011 ◽  
Vol 60 (3) ◽  
pp. 552-556
Author(s):  
Azusa Tanaka ◽  
Eiichi Nakamura ◽  
Yasunari Oniki ◽  
Nobukazu Okamoto ◽  
Hiroaki Nishioka ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Venous Thromboembolism ◽  
Knee Arthroplasty ◽  
Total Knee ◽  
D Dimer

scholarly journals Early ambulation after total knee arthroplasty prevents patients with osteoarthritis and rheumatoid arthritis from developing postoperative higher levels of D-dimer

2010 ◽  
Vol 57 (1,2) ◽  
pp. 146-151 ◽  
Author(s):  
Shigetaka Nakao ◽  
Shinjiro Takata ◽  
Hirokazu Uemura ◽  
Shunji Nakano ◽  
Hiroshi Egawa ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Early Ambulation ◽  
Total Knee ◽  
D Dimer

scholarly journals Multiple-Dose Intravenous Tranexamic Acid in Total Knee Arthroplasty in Patients with Rheumatoid Arthritis: A Randomized Controlled Study

2020 ◽  
Author(s):  
Bing-xin Kang ◽  
Hui Xu ◽  
Chen-xin Gao ◽  
Sheng Zhong ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Randomized Controlled ◽  
Group A ◽  
Total Knee ◽  
Group B ◽  
D Dimer

Abstract Background: To identify the efficacy and safety of multiple doses of intravenous tranexamic acid (IV-TXA) on perioperative blood loss in patients with rheumatoid arthritis (RA) who underwent primary unilateral total knee arthroplasty (TKA).Methods: In this single-center, single-blind randomized controlled clinical trial, ten male and 87 female participants aged 50–75 years, with RA who underwent unilateral primary TKA were randomly assigned (1:1) to receive a single dose of IV-TXA (1 g) for 3 h (group A) or three doses of IV-TXA (1 g) for 3, 6, and 12 h (group B) postoperatively. Primary outcomes were total red blood cell loss (TBL), hidden red blood loss (HBL) and maximum hemoglobin (Hb) drop. Secondary outcomes were transfusion rate and levels of D-dimer. All parameters were measured post-operatively during inpatient hospital stay.Results: Between September 2019 and May 2020, 104 participants were randomized. 7 were lost follow-up. Mean TBL, HBL, and maximum Hb drop in group B (506.1 ± 227.0 mL, 471.6 ± 224.0 mL, and 17.5 ± 7.7 g/L, respectively) were significantly lower than those in groups A (608.8 ± 244.8 mL, P = 0.035; 574.0 ± 242.3 mL, P = 0.033; and 23.42 ± 9.2 g/L, P = 0.001, respectively). No episode of transfusion occurred. D-dimer level was lower in group B than in group A on post-operative day 1 (P < 0.001), and the incidence of thromboembolic events was similar between the two groups (P > 0.05). Conclusion: Three doses of post-operative IV-TXA could further reduced blood loss, maximum Hb drop, and diminished the postoperative fibrinolytic responses without increasing the risk of complications.Trial registration: The trial was registered in Chinese Clinical Trial Registry (ChiCTR1900025013).Name of the registry: Clinical observation of multiple dose use of tranexamic acid in patients with rheumatoid arthritis after total knee arthroplasty. Prospective registration, ChiCTR1900025013. Registered 7 August 2019, http://www.chictr.org.cn/showproj.aspx?proj=41375

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