Procalcitonin to C-reactive protein ratio is associated with short-term mortality in ischemic stroke patients: preliminary report

Abstract Studies on the association of C-reactive protein (CRP) with all-cause mortality in acute ischemic stroke patients have yielded conflicting results. The objective of this meta-analysis was to evaluate the prognostic value of CRP elevation in predicting all-cause mortality amongst patients with acute ischemic stroke. We searched the original observational studies that evaluated the association of CRP elevation with all-cause mortality in patients with acute ischemic stroke using PubMed and Embase databases until 20 January 2018. Pooled multivariate-adjusted hazard ratio (HR) with 95% confidence intervals (CI) of all-cause mortality was obtained for the highest compared with the lowest CRP level or per unit increment CRP level. A total of 3604 patients with acute ischemic stroke from eight studies were identified. Acute ischemic stroke patients with the highest CRP level were independently associated with an increased risk of all-cause mortality (HR: 2.07; 95% CI: 1.60–2.68) compared with the lowest CRP category. The pooled HR of all-cause mortality was 2.40 (95% CI: 1.10–5.21) for per unit increase in log-transformed CRP. Elevated circulating CRP level is associated with the increased risk of all-cause mortality in acute ischemic stroke patients. This meta-analysis supports the routine use of CRP for the death risk stratification in such patients.

Download Full-text

High-sensitivity C-reactive protein in HIV care: Tuberculosis diagnosis and short-term mortality in a cohort of Kenyan HIV patients in the DREAM programme

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2021.01.008 ◽

2021 ◽

Vol 104 ◽

pp. 329-334

Author(s):

Fausto Ciccacci ◽

Benjamin Welu ◽

Harrison Ndoi ◽

Irene Karea ◽

Stefano Orlando ◽

...

Keyword(s):

High Sensitivity ◽

Hiv Care ◽

C Reactive Protein ◽

Short Term ◽

Hiv Patients ◽

Reactive Protein ◽

Short Term Mortality ◽

Tuberculosis Diagnosis

Download Full-text

Albumin and C-reactive protein levels predict short-term mortality after percutaneous endoscopic gastrostomy in a prospective cohort study

Yearbook of Gastroenterology ◽

10.1016/j.ygas.2011.08.008 ◽

2011 ◽

Vol 2011 ◽

pp. 194-195

Author(s):

J.A. Murray

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Percutaneous Endoscopic Gastrostomy ◽

Prospective Cohort ◽

C Reactive Protein ◽

Short Term ◽

Protein Levels ◽

Reactive Protein ◽

Endoscopic Gastrostomy ◽

Short Term Mortality

Download Full-text

Vitamin D deficiency is associated with acute ischemic stroke, C-reactive protein, and short-term outcome

Metabolic Brain Disease ◽

10.1007/s11011-016-9939-2 ◽

2016 ◽

Vol 32 (2) ◽

pp. 493-502 ◽

Cited By ~ 28

Author(s):

Daniela Frizon Alfieri ◽

Márcio Francisco Lehmann ◽

Sayonara Rangel Oliveira ◽

Tamires Flauzino ◽

Francieli Delongui ◽

...

Keyword(s):

Vitamin D ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Vitamin D Deficiency ◽

C Reactive Protein ◽

Short Term ◽

Term Outcome ◽

Reactive Protein ◽

Short Term Outcome

Download Full-text

CORRELATION BETWEEN NEUTROPHIL-TO-LYMPHOCYTE RATIO AND HIGH SENSITIVITY C REACTIVE PROTEIN WITH SEVERITY AND OUTCOME IN ACUTE ISCHEMIC STROKE PATIENT

International journal of Research science and Management - September-2020 ◽

10.29121/ijrsm.v7.i8.2020.11 ◽

2020 ◽

Vol 7 (8) ◽

pp. 75-80

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

High Sensitivity ◽

Neutrophil To Lymphocyte Ratio ◽

C Reactive Protein ◽

Stroke Patients ◽

Cross Sectional ◽

Acute Ischemic Stroke Patient ◽

Lymphocyte Ratio ◽

Reactive Protein

Background: Inflammation plays a role in the pathophysiology of cerebral ischemic and also an initial response to brain injury. Inflammation involving Blood and Brain Barrier disturbance, leukocyte infiltration, endothelial cells activation, oxidant and inflammatory mediator buildups which can develop rapidly within hours and can cause secondary injury to brain tissues Objectives: To determine the correlation between Neutrophil-to-Lymphocyte Ratio (NLR) and High Sensitivity C Reactive Protein (hsCRP) with severity and outcome in acute ischemic stroke patients Methods: This study used a cross-sectional design approach. Sampling was done at H. Adam Malik General Hospital Medan and taken as many as 38 subjects. NLR and hsCRP were examined on the first day of admission. Severity was assessed by using the National Institutes of Health Stroke Scale and the outcome was assessed by using the Modified Ranking Scale on the first and fourteenth day of admission. The data analysis used the contingency coefficient correlation test and gamma test. Results: Demographic characteristics of the subjects are; the average age is 62 years old, the highest educational level is high school graduate, and the most occupation is unemployed. There is a positive, moderate, and significant correlation between NLR and severity of acute ischemic stroke (r=0.511; p=0.001). There is a positive, moderate, and significant correlation between NLR and the outcome of acute ischemic stroke (r=0.463; p=0.001). There is a positive, very strong, and significant correlation between hsCRP and severity of acute ischemic stroke (r=0.896; p=0.001). There is a positive, strong, and significant correlation between hsCRP and outcome of acute ischemic stroke (r=0.624; p=0.001) Conclusions: There is a positive and significant correlation between NLR and hsCRP with severity and outcome in acute ischemic stroke patients.

Download Full-text