Polarising Frantz Tumors – Benign And Malignant Solid Pseudopapillary Epithelial Neoplasm Of Pancreas – Twin Case Reports

Solid pseudo-papillary epithelial neoplasm (SPEN), also known Hamoudi tumors or Franz tumors, are rare pancreatic neoplasm which are almost always seen in young women predominately of non-Caucasian descent with only a small minority of cases diagnosed in men [1]. The first published description of an SPN was by Frantz in 1959[2]. . It is a rare tumor comprising of less than 3 percent of all pancreatic tumor. It is seen most often in the region of tail of pancreas. This tumor is mostly asymptomatic and usually detected when it reaches large size. These are tumors with low malignant potential and rarely vascular invasion and metastatic disease can be seen in aggressive cases. Here we report two cases, one each of benign SPEN and malignant SPEN with contrasting imaging findings and polar outcomes.

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Lymphatic Vascular Invasion in Ovarian Serous Tumors of Low Malignant Potential With Stromal Microinvasion

The American Journal of Surgical Pathology ◽

10.1097/pas.0b013e318141fc7a ◽

2008 ◽

Vol 32 (2) ◽

pp. 261-268 ◽

Cited By ~ 18

Author(s):

Ankur R. Sangoi ◽

Jesse K. McKenney ◽

Soheil S. Dadras ◽

Teri A. Longacre

Keyword(s):

Vascular Invasion ◽

Malignant Potential ◽

Low Malignant Potential ◽

Serous Tumors

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Solid pseudopapillary tumor of the pancreas: Clinical features, diagnosis and treatment

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.63.03.219 ◽

2017 ◽

Vol 63 (3) ◽

pp. 219-223 ◽

Cited By ~ 3

Author(s):

Carlos Anselmo Lima ◽

Angela Silva ◽

Carlos Alves ◽

Antonio Alves Jr. ◽

Sonia Lima ◽

...

Keyword(s):

Young Women ◽

Survival Rates ◽

Surgical Excision ◽

Complete Resection ◽

Malignant Potential ◽

Solid Pseudopapillary Tumor ◽

Computed Tomography Scan ◽

Complete Surgical Excision ◽

Low Malignant Potential ◽

Tomography Scan

Summary Introduction: Solid pseudopapillary tumor of the pancreas (SPTP) is a rare neoplasm of low malignant potential with uncertain behavior, diagnosed mainly in young women. Method: Our report comprises a series of cases of SPTP reviewed retrospectively, highlighting clinical, tomographic and immunohistochemical features, treatment performed and outcomes. Results: Thirteen patients were found to have pancreatic [solid] masses on computed tomography scan measuring a mean diameter of 8.8 cm. All patients underwent complete surgical excision. Immunohistochemistry confirmed diagnosis in all cases. Conclusion: SPTP occurs more frequently in young women. Diagnostic suspicion lies on the finding of a bulky, solid and cystic pancreatic mass. Imaging findings might provide diagnostic information before resection. Conservative approaches can be used in selected cases and survival rates are usually excellent following complete resection.

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A Primary Retroperitoneal Mucinous Tumor

Case Reports in Surgery ◽

10.1155/2015/157613 ◽

2015 ◽

Vol 2015 ◽

pp. 1-3

Author(s):

Alicia A. Heelan Gladden ◽

Max Wohlauer ◽

Martine C. McManus ◽

Csaba Gajdos

Keyword(s):

Case Reports ◽

Mucinous Carcinoma ◽

Malignant Potential ◽

Mucinous Tumor ◽

Retroperitoneal Mass ◽

Surveillance Imaging ◽

Mucinous Neoplasms ◽

Low Malignant Potential ◽

Mucinous Cystadenomas ◽

Primary Retroperitoneal

A twenty-five-year-old female presented with a large retroperitoneal mass. Workup included history and physical exam, imaging, biopsy, colonoscopy, and gynecologic exam. After surgical resection, the mass was determined to be a primary retroperitoneal mucinous tumor (PRMT). Clinically and histologically, these tumors are similar pancreatic and ovarian mucinous neoplasms. PRMTs are rare and few case reports have been published. PRMTs are divided into mucinous cystadenomas, mucinous borderline tumors of low malignant potential, and mucinous carcinoma. These tumors have malignant potential so resection is indicated and in some cases adjuvant chemotherapy and/or surveillance imaging.

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Frantz’s Tumour an Unusual Pancreatic Neoplasm: A Case Report

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2020/45272.14168 ◽

2020 ◽

Author(s):

Mejri Atef ◽

Khaoula Arfaoui ◽

Jasser Yaakoubi ◽

Bacha Dhouha ◽

Najet Mahjoub

Keyword(s):

Young Women ◽

Solid Tumour ◽

Pancreatic Neoplasm ◽

Surgical Excision ◽

Good Prognosis ◽

Cross Sectional ◽

Blood Tests ◽

Cross Sectional Imaging ◽

History Of ◽

Epithelial Neoplasm

Solid-Pseudopapillary Tumour of the pancreas (SPT) or Frantz’s tumour is a rare epithelial neoplasm and represents 2% of exocrine pancreatic tumours. Its origin remains enigmatic and they are of little known aetiopathogenesis. These tumours occur in young women and must be suspected in any case of left hypochondrium’s mass. It has a good prognosis through radical surgical excision. The five-year survival rate is around 97%. Here, the authors present a case of 26-year-old female patient, who presented to the Emergency Department with three weeks history of abdominal pain and vomiting. Physical examination did not reveal any abnormalities and her blood tests were normal. Cross-sectional imaging modalities which showed a caudal pancreatic mass with cystic and necrotico-haemorrhagic components evocative of a pseudo-papillary solid tumour of the pancreas. The patient had a distal pancreatectomy and splenectomy with good outcome.

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Invasive Recurrence of an Intestinal-Type Mucinous Epithelial Neoplasm of Low Malignant Potential: Case Report and Review of the Literature

Case Reports in Oncology ◽

10.1159/000331416 ◽

2011 ◽

Vol 4 (2) ◽

pp. 426-432

Author(s):

S. Cosyns ◽

M. Leyder ◽

C. Bourgain ◽

P. De Sutter

Keyword(s):

Case Report ◽

Malignant Potential ◽

Intestinal Type ◽

Review Of The Literature ◽

Low Malignant Potential ◽

Potential Case ◽

Epithelial Neoplasm

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Current controversies in the biology and management of ovarian tumors of low malignant potential

The Women s Oncology Review ◽

10.3109/14733400600604448 ◽

2007 ◽

Vol 6 (1-2) ◽

pp. 15-25

Author(s):

William E. Winter ◽

Douglas N. Brown ◽

Charles A. Leath

Keyword(s):

Malignant Potential ◽

Ovarian Tumors ◽

Low Malignant Potential

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Spontaneous haemorrhage of an adrenal angiomyolipoma: case report

African Journal of Urology ◽

10.1186/s12301-019-0006-1 ◽

2019 ◽

Vol 25 (1) ◽

Author(s):

Danielle Whiting ◽

Ian Rudd ◽

Amit Goel ◽

Seshadri Sriprasad ◽

Sanjeev Madaan

Keyword(s):

Case Reports ◽

Case Presentation ◽

Open Adrenalectomy ◽

Large Size ◽

History Of ◽

Loin Pain ◽

Benign Tumours ◽

Spontaneous Haemorrhage ◽

Mesenchymal Tumours

Abstract Background Angiomyolipomas are rare mesenchymal tumours arising from the perivascular epithelioid cells consisting of variable amounts of adipose, thick-walled blood vessels and smooth muscle cells. These benign tumours commonly occur in the kidney with only a few case reports of adrenal angiomyolipomas which have the potential to reach a large size and haemorrhage. Case presentation A 45-year-old lady presented with a 3-week history of right loin pain, nausea and vomiting. A CT scan revealed a right adrenal angiomyolipoma measuring 6.3 × 6.8 cm with associated haemorrhage. The lesion was successfully treated with right open adrenalectomy, and histology confirmed the diagnosis of adrenal angiomyolipoma. The patient remained well with no evidence of recurrence at the 36-month follow-up. Conclusion Adrenal angiomyolipomas are rare benign tumours that have the ability to reach a large size and potential to bleed. Here, we report the second case of spontaneous haemorrhage in an adrenal angiomyolipoma, which was successfully treated with open adrenalectomy.

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Ovarian mature cystic teratoma with malignant transformation: two case reports

Journal of Medical Case Reports ◽

10.1186/s13256-020-02594-4 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Afsaneh Tehranian ◽

Akram Ghahghaei-Nezamabadi ◽

Akram Seifollahi ◽

Sara Kasraei ◽

Hamideh Dehghani-Nejad ◽

...

Keyword(s):

Malignant Transformation ◽

Case Reports ◽

Cystic Teratoma ◽

Good Prognosis ◽

Mature Cystic Teratoma ◽

Treatment Protocols ◽

Large Size ◽

Stage Ia ◽

Loss Of Appetite ◽

Case Number

Abstract Background Mature Cystic Teratoma (MCT) is a benign tumor that can lead to malignant transformation (MT) in 1–3% of cases. Management of MT is a big challenge for gynecologic oncologists due to the lack of specific diagnostic and treatment protocols. Case presentation We reported two Iranian cases of MT of MCT with two different stages and prognosis. Our both cases presented the same symptoms, including chronic abdominal pain and distention, loss of appetite, and weight loss. In case number 1, despite the large size of the tumor, the disease was at stage Ia and had a good prognosis; while, case number 2 was at stage IIIc of the disease with a poor prognosis. Conclusion The stage of the disease is the most important prognostic factor, and early diagnosis and treatment are very critical for better survival.

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Comparison of clinicopathological features and long-term prognosis between mixed predominantly differentiated-type and pure differentiated-type early gastric cancer

BMC Cancer ◽

10.1186/s12885-021-07962-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Yutaka Okagawa ◽

Tetsuya Sumiyoshi ◽

Hitoshi Kondo ◽

Yusuke Tomita ◽

Takeshi Uozumi ◽

...

Keyword(s):

Gastric Cancer ◽

Early Gastric Cancer ◽

Vascular Invasion ◽

Survival Rates ◽

Malignant Potential ◽

Clinicopathological Features ◽

Node Metastasis ◽

Group 5 ◽

Long Term Prognosis

Abstract Background Recent studies have shown that mixed predominantly differentiated-type (MD) early gastric cancer (EGC) might have more malignant potential than pure differentiated-type (PD) EGC. However, no study has analyzed all differentiated-type EGC cases treated endoscopically and surgically. This study aimed to compare the differences in clinicopathological features and long-term prognosis between MD- and PD-EGC. Methods We evaluated all patients with differentiated-type EGCs who were treated endoscopically and surgically in our hospital between January 2010 and October 2014. The clinicopathological features and long-term prognosis of MD-EGC were compared with those of PD-EGC. Results A total of 459 patients with 459 lesions were evaluated in this study; of them, 409 (89.1%) and 50 (10.9%) were classified into the PD and MD groups, respectively. Submucosal invasion was found in 96 (23.5%) patients of the PD group and in 33 (66.0%) patients of the MD group (p < 0.01). The rates of positive lymphatic and vascular invasion and ulceration were significantly higher in the MD group than in the PD group (p < 0.01). The proportion of patients with lymph node metastasis was also significantly higher in the MD group than in the PD group (5 (10%) vs 6 (1.5%), p < 0.01). The 5-year overall and EGC-specific survival rates in the PD group were 88.3 and 99.5%, respectively, while they were 94.0 and 98.0% in the MD group, respectively. Conclusions MD-EGC has more malignant potential than PD-EGC. However, the long-term prognosis of MD-EGC is good and is not significantly different from that of PD-EGC when treated appropriately.

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