Ocular manifestations of Parkinson disease

2020 ◽  
Vol 1 (1) ◽  
pp. 1-10
Author(s):  
Mashael Al-Namaeh
Keyword(s):  
Early Diagnosis ◽  
Neurodegenerative Disorder ◽  
Imaging Techniques ◽  
Field Tests ◽  
Ocular Manifestations ◽  
Convergence Insufficiency ◽  
Eye Movement Disorders ◽  
Rule Out

Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder. We aimed to review both the disease and the drug-related ocular manifestations of PD. Methods: In this manuscript, we have reviewed and summarized existing literature on the ocular manifestations and drug-related complications of PD. We have also discussed the use of current noninvasive imaging techniques, such as optical coherence tomography (OCT), for the early diagnosis and monitoring of PD. Results: Impaired color vision, reduced stereopsis, reduced contrast sensitivity, pupillary abnormalities, eye movement disorders, convergence insufficiency, dry eye syndrome, glaucoma, visual dysfunctions, retinal abnormalities, and drug-related side effects were among the listed ocular manifestations of PD. There is a large knowledge gap regarding the type of glaucoma affecting PD patients—whether it is open-angle or other types. Further case studies and long-term follow-ups during PD progression are necessary to fill this gap. Patient compliance with follow-up visits for more visual field tests and OCT during PD progression may become problematic when dementia and cognitive impairment occur. Conclusions: There is a general need for clinicians to perform further tests and more visual examinations to rule out ocular manifestations. Furthermore, additional clinical trials are needed to further evaluate the use of different types of OCT findings as biomarkers of PD progression. This would aid in early diagnosis and in delaying disease progression, if treated promptly.

scholarly journals Myopericytoma in the Antitragus of the Auricle: A Rare Tumor

2020 ◽  
pp. 014556132098457
Author(s):  
Tae Seong Eo ◽  
Jeong Hae Kie ◽  
Hyun Seung Choi ◽  
Junhui Jeong
Keyword(s):  
Large Firm ◽  
Rare Tumor ◽  
Long Term Follow Up ◽  
Slow Growing ◽  
Rule Out

A myopericytoma in the auricle is rare. If an auricle contains a large, firm, red-brown mass, excision should be considered because the mass may be a myopericytoma. After excision, histopathological and immunohistochemical diagnoses are essential to rule out malignancy. Long-term follow-up is required because the tumor is slow-growing.

Endocarditis

2015 ◽  
pp. 230-244
Author(s):  
Gilbert Habib ◽  
Franck Thuny
Keyword(s):  
Infective Endocarditis ◽  
Imaging Techniques ◽  
Prosthetic Valve Endocarditis ◽  
Transoesophageal Echocardiography ◽  
Pet Ct ◽  
Long Term Prognosis ◽  
Severity Of The Disease ◽  
Fdg Pet Ct

Imaging plays a key role in the assessment of infective endocarditis. Echocardiography, particularly transoesophageal echocardiography, gives useful information concerning the diagnosis of infective endocarditis, the assessment of the severity of the disease, the prediction of short-term and long-term prognosis, and the follow-up of patients under specific antibiotic therapy. Other imaging techniques, including magnetic resonance imaging, Computed tomography (CT) scan, and invasive angiography, are of limited value for the diagnosis of infective endocarditis, but are useful for the diagnosis and management of its complications. FDG PET/CT imaging seems the most promising new imaging technique, particularly for the diagnosis of prosthetic valve endocarditis

scholarly journals P1799 The importance of 3D imaging techniques in left atrial appendage closure: landing zone eccentricity influence on peri-device leak incidence and its implication in long-term clinical outcomes

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
G Italiano ◽  
A Maltagliati ◽  
V Mantegazza ◽  
A Gasperetti ◽  
L Fusini ◽  
...  
Keyword(s):  
Left Atrial ◽  
3D Imaging ◽  
Left Atrial Appendage ◽  
Imaging Techniques ◽  
Thromboembolic Events ◽  
Landing Zone ◽  
Device Implantation ◽  
Device Size

Abstract Background A complex left atrial appendage (LAA) morphology and a non-circular landing zone (LZ) are frequently encountered in patients undergoing percutaneous LAA occlusion (LAAO). Three-dimensional (3D) imaging modalities as 3D transoesophageal echocardiography (3D TOE) and cardiac computed tomography (CCT) should be preferred over two dimensional techniques for better evaluation of LAA diameters, especially for the LZ. In fact, non-circular shape could impair the choice of occluder device size and may be implicated in the occurrence of residual leaks. Incomplete LAA occlusion is recognized to be associated with thromboembolic events. Purpose The aim of the study was to evaluate the utility of 3D imaging techniques to predict LAA device size and the landing zone eccentricity index as a potential predictor of residual peri-device leaks and to assess their clinical implications on long-term follow-up. Methods It was a retrospective, single-center study including 137 consecutive patients undergoing successful LAAO from January 2010 to July 2018. Pre-procedural 3D TOE and CCT were used to predict device size based upon LZ diameters and quantify LAA orifice eccentricity. Leaks were defined as the presence of peri-device flow at 2D TOE immediately after the device implantation and at 3 months follow-up. Leaks were classified as significant (color jet width ≥4 mm) or minor (<3 mm). A clinical evaluation of thromboembolic events was performed at 48 ± 27 months from the procedure. Results LAAO closure was performed implanting either Amulet or Watchman devices (n = 98 and n = 40, respectively). The assessment of LZ measurements with 3D TOE and CCT showed a significant correlation with the device size selected on the basis of 2D techniques (r = 0.82 and r = 0.74, respectively). As concerns the peri-device leaks, the presence of an eccentric LZ (eccentricity index >0.20) was not associated to the development of post-procedural leaks in the overall population; a significant correlation was detected only in the subgroup of patients treated with the Amulet device (p = 0.045). Residual leaks included only 1 significant leak (0.7%) after Amulet device implantation, which was related to a major neurological event (stroke) and 47 (34%) minor leaks (n = 28 in the Amulet group, n = 19 in the Watchman group). In this last population, 2 patients (1.5%) developed minor neurological events (transient ischemic attack). Conclusions 3D TOE and CCT better predict device size overcoming the limit of 2D imaging techniques undersizing. In eccentric LAA, Watchman device may reduce the incidence of peri-device leaks. The presence of significant residual leaks is uncommon but associated with major clinical events, whilst minor leaks are relatively frequent but do not seem to be related to life-threatining thromboembolic accidents.

scholarly journals Type 1 Choroidal Neovascularization Evolution by Optical Coherence Tomography Angiography: Long-Term Follow-Up

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Marco Rispoli ◽  
Maria Cristina Savastano ◽  
Bruno Lumbroso ◽  
Lisa Toto ◽  
Luca Di Antonio
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Neovascularization ◽  
Structural Changes ◽  
Imaging Techniques ◽  
Optical Coherence ◽  
Anti Vegf ◽  
The Mean

Purpose. To evaluate structural changes in response to antivascular endothelial growth factor (anti-VEGF) treatment in patients with long-term type 1 choroidal neovascularization (CNV) by optical coherence tomography (OCT) and OCT angiography (OCTA). Method. This is a longitudinal study that involved a total of 51 eyes with type 1 CNV (35 female and 16 male eyes). Structural OCT and OCTA were performed on all the subjects. AngioVue OCTA (XR Avanti, Optovue, Inc., Fremont, CA) was used to obtain qualitative and quantitative information. All eyes were treated with an anti-VEGF ProReNata (PRN) approach and were followed for a mean of 38.9 months (SD±7.22). Best-corrected visual acuity (BCVA) was assessed at each follow-up timepoint. Results. We observed two kinds of possible evolution of type 1 CNV: “positive evolution,” including stabilization in 20% of patients and chronicity in 35%, and “negative evolution,” in which fibrosis was shown in 18% of patients, chorioretinal atrophy in 25%, and hemorrhage or RPE tears in 2%. The mean BCVA at baseline was 33.67±15.85 ETDRS letters; after 1 and 2 years, it was 31.61±18.04 and 31.18±18.58 ETDRS letters, respectively. The mean BCVA at the end of follow-up was 25.27±20 ETDRS letters. The difference between the values at baseline and at the end of follow-up was not statistically significant (P=0.06, r2=0.10). Conclusions. This study describes an in vivo structural long-term evolution of type 1 CNV by OCT and OCTA. Different possible CNV outcomes were observed. This study suggests that new retinal imaging techniques could be useful tools for assessing the potential retinal changes in the evolution of type 1 CNV to develop personalized medicine. Further studies using OCTA in the long term are needed to better understand why similarly treated type 1 CNV cases evolve differently and produce different results.

scholarly journals Prognostic factors for the long-term development of ocular lesions in 327 children with congenital toxoplasmosis

2003 ◽  
Vol 131 (3) ◽  
pp. 1157-1168 ◽  
Author(s):  
C. BINQUET ◽  
M. WALLON ◽  
C. QUANTIN ◽  
L. KODJIKIAN ◽  
J. GARWEG ◽  
...  
Keyword(s):  
Cox Model ◽  
Congenital Toxoplasmosis ◽  
Maternal Infection ◽  
High Risk Factors ◽  
Ocular Manifestations ◽  
Standardized Protocol ◽  
Ocular Lesions ◽  
Bilateral Impairment

The aim of this study was to identify the high-risk factors associated with the development of ocular lesions in a large cohort of children with congenital toxoplasmosis (CT), irrespective of their gestational age at the time of maternal infection. Children were managed according to a standardized protocol and monitored for up to 14 years at the Croix-Rousse Hospital, Lyon, France. Cox model and a flexible regression, spline-based method were used for the analysis. During a median follow-up time of 6 years, 79 of the 327 children (24%) had at least one retinochoroidal lesion. No bilateral impairment of visual acuity was observed. The risk of a child developing ocular disease was higher not only when mothers were infected early during pregnancy, which was expected, but also when CT was diagnosed prior to or at the time of birth, when non-ocular manifestations were present at baseline and when birth was premature.

scholarly journals Echocardiographic Advances in Dilated Cardiomyopathy

2021 ◽  
Vol 10 (23) ◽  
pp. 5518
Author(s):  
Andrea Faggiano ◽  
Carlo Avallone ◽  
Domitilla Gentile ◽  
Giovanni Provenzale ◽  
Filippo Toriello ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Imaging Techniques ◽  
Standard Technique ◽  
Research Area ◽  
New Developments ◽  
Long Term Follow Up ◽  
And Performance ◽  
Near Future

Although the overall survival of patients with dilated cardiomyopathy (DCM) has improved significantly in the last decades, a non-negligible proportion of DCM patients still shows an unfavorable prognosis. DCM patients not only need imaging techniques that are effective in diagnosis, but also suitable for long-term follow-up with frequent re-evaluations. The exponential growth of echocardiography’s technology and performance in recent years has resulted in improved diagnostic accuracy, stratification, management and follow-up of patients with DCM. This review summarizes some new developments in echocardiography and their promising applications in DCM. Although nowadays cardiac magnetic resonance (CMR) remains the gold standard technique in DCM, the echocardiographic advances and novelties proposed in the manuscript, if properly integrated into clinical practice, could bring echocardiography closer to CMR in terms of accuracy and may certify ultrasound as the technique of choice in the follow-up of DCM patients. The application in DCM patients of novel echocardiographic techniques represents an interesting emergent research area for scholars in the near future.

Long-term normalization of cognitive and psychopathological alterations in a juvenile Niemann–Pick type C case

2020 ◽  
Vol 10 (2) ◽  
pp. 73-80
Author(s):  
María de la Concepción Fournier del Castillo ◽  
Silvia Cámara Barrio ◽  
Borja Esteso Orduña ◽  
Izaskun Basterra Jiménez ◽  
Laura López Marín ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Adult Onset ◽  
Juvenile Onset ◽  
Neuropsychological Development ◽  
Impaired Cognitive Function ◽  
Type C ◽  
Niemann Pick ◽  
Lipid Storage Disorder

Niemann–Pick type C (NP-C) disease is a neurovisceral atypical lysosomal lipid storage disorder with a poor prognosis. We present the 5-year neuropsychological follow-up of a patient with juvenile onset NP-C, spanning the pre-diagnostic stage to the period after treatment with miglustat (Actelion Pharmaceuticals Inc., CA, US). In the initial stages of the disease, the patient presented behavioral dysexecutive symptoms resembling those frequently observed in adult-onset forms and frontotemporal dementia, which frequently makes early diagnosis difficult in children. After 4 years of treatment, the impaired cognitive function and behavioral dysexecutive syndrome had been completely reversed. The variability of NP-C disease makes early diagnosis challenging. Evaluations of long-term neuropsychological development can help diagnose this neurodegenerative disease and document its progression.

OP03.07: Placenta percreta: early diagnosis and long term follow up by MRI and ultrasound with a placenta left in situ

2007 ◽  
Vol 30 (4) ◽  
pp. 465-465
Author(s):  
F. Chantraine ◽  
A. Thille ◽  
B. Tutschek ◽  
J. P. Schaaps ◽  
J. M. Foidart
Keyword(s):  
Early Diagnosis ◽  
Placenta Percreta ◽  
Long Term Follow Up

Gender influence on ocular manifestations and their outcome in Behcet’s Disease. A long-term follow-up of up to 20 years

2010 ◽  
Vol 30 (4) ◽  
pp. 541-547 ◽  
Author(s):  
Fereydoun Davatchi ◽  
Farhad Shahram ◽  
Hormoz Shams ◽  
Abdolhadi Nadji ◽  
Cheyda Chams-Davatchi ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease ◽  
Ocular Manifestations ◽  
Gender Influence ◽  
Long Term Follow Up

Oligodendroglioma arising in the glial component of ovarian teratomas: a series of six cases and review of literature

2012 ◽  
Vol 65 (7) ◽  
pp. 631-634 ◽  
Author(s):  
Nasir Ud Din ◽  
Aisha Memon ◽  
Kanwal Aftab ◽  
Zubair Ahmad ◽  
Rashida Ahmed ◽  
...  
Keyword(s):  
Review Of Literature ◽  
Ki 67 ◽  
Who Grade ◽  
Long Term Follow Up ◽  
Grade Ii ◽  
The Right ◽  
Rule Out ◽  
Ovarian Teratomas

AimsTo report the exceedingly rare occurrence of oligodendroglioma in the glial component of ovarian teratomas.MethodsSix cases of oligodendrogliomas arising in the glial component of ovarian teratomas were studied and the literature was reviewed. Immunohistochemistry was performed by the Flex technique.ResultsThe ages of the patients ranged from 12 to 28 years (mean 21 years). Four tumours were located in the right and one in the left ovary. The size of the ovarian cysts ranged from 7 cm to 29 cm (mean 19.6 cm). Four cases arose in immature and two cases in mature teratomas. In all cases, oligodendroglioma was WHO grade II. On immunohistochemistry, glial fibrillary acidic protein stain was positive in all cases. The Mib 1 (Ki 67) proliferative index was low and the tumour cells were negative for synaptophysin. Follow-up was available in five patients and ranged from 1 to 42 months. Two patients died of disease after 1 and 36 months of diagnosis, respectively. In both these cases oligodendroglioma arose in an immature teratoma. The remaining three patients are alive with a follow-up of 4–42 months.ConclusionsOligodendroglioma arising in the glial component of ovarian teratomas is exceedingly rare. Ovarian teratomas should be extensively sampled and carefully evaluated to rule out the possibility of a glial tumour. This is the single and largest series of oligodendrogliomas arising in ovarian teratomas. The prognosis is good for oligodendrogliomas arising in mature teratomas compared with those arising in immature teratomas, although long-term follow-up is needed to determine the exact behaviour.

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