scholarly journals Effect of Body Mass Index on the Outcome of In-vitro Fertilization/Intracytoplasmic Sperm Injection

BioMedica ◽  
2020 ◽  
Vol 36 (4) ◽  
pp. 394-399
Author(s):  
Zoofishan Imran ◽  
Haroon Latif Khan ◽  
Rafia Nafees ◽  
Humaira Humayun ◽  
Rameen Nisar

Background and Objective: Obesity is becoming a global issue related to many health problems, and infertility is one of them. It has been established in literature that obesity or increased body mass index (BMI) harms the ability of a woman to conceive. Assisted reproductive techniques e.g., in-vitro fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI) are helping infertile women to conceive. This study's objective was to analyze the effect of BMI on IVF/ICSI treatment outcomes in infertile women. Methods: This was a retrospective cross-sectional study. Samples of 500 patients aged less than 40 years were selected at a tertiary care infertility center: Lahore Institute of Fertility and Endocrinology, Hameed Latif Hospital. The sample was collected from January 2019 to June 2019. A structured proforma was used to collect information about selected anthropometric measurements and ultrasonography findings from the files and follow-ups of the selected patients. Data was processed and analyzed in Statistical Package for Social Sciences (SPSS) version 20.0. Results: The age of the subjects ranged from 18 to 39 years, with a maximum number of subjects in the age category 31 to 35 years. BMI was significantly associated with number of follicles retrieved and clinical pregnancy rate (P= 0.001). Conclusion: Normal BMI has positive impact both on follicular response in controlled ovarian stimulation (COS) and clinical pregnancy rates in women undergoing IVF/ICSI treatment.

2021 ◽  
Author(s):  
Zeynep Ozturk Inal ◽  
Hasan Ali Inal

Abstract Purpose: To evaluate whether or not maternal body mass index (BMI) has an effect on pregnancy rates following in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) treatment.Methods: A total of 869 patients who had undergone IVF-ICSI treatment between 2012 and 2017 were included in this study. The participants were stratified according to maternal BMI as Group 1 (BMI<25 kg/m2; n=394), Group 2 (25 kg/m2<BMI <30 kg/m2; n=303), and Group 3 (BMI>25 kg/m2; n=172). Basal parameters and IVF-ICSI outcomes were compared between the groups.Results: While there were no differences between the groups in terms of age, smoking status, etiology of infertility, thyroid-stimulating hormone, prolactin levels, antral follicle count, and stimulation protocol (p>0.05), there was significant statistical difference (p<0.05) in terms of BMI, duration of infertility, baseline follicle-stimulating hormone, luteinizing hormone, estradiol (E2), duration of stimulation, total gonadotropin dose required, peak E2 levels, progesterone levels, endometrial thickness on hCG administration, and cycle cancellation rate. In addition, the numbers of MII and 2PN oocytes retrieved and the rates of clinical pregnancy, live births, and miscarriages were also different between the groups (p<0.05).Conclusion: Our data suggest that there is an inverse impact of increased BMI on laboratory and reproductive outcome parameters of IVF-ICSI treatment. Taking cost-effectiveness into consideration, weight loss should be suggested before ovulation is induced.


2017 ◽  
Vol 23 (7) ◽  
pp. 7009-7011 ◽  
Author(s):  
Shabrina Narasati ◽  
Oki Riayati ◽  
Budi Wiweko ◽  
Achmad Kemal Harzif ◽  
Gita Pratama ◽  
...  

1999 ◽  
Vol 14 (Suppl_3) ◽  
pp. 299-299
Author(s):  
C. Wittemer ◽  
J. Ohl ◽  
K. Bettahar-Lebugle ◽  
M. Bailly ◽  
C. Rongières ◽  
...  

2016 ◽  
Vol 39 (5) ◽  
pp. 1723-1734 ◽  
Author(s):  
Na Cui ◽  
Huixia Wang ◽  
Wei Wang ◽  
Jie Zhang ◽  
Yueming Xu ◽  
...  

Background: The aim of this study is to assess the effect of body mass index (BMI) on outcomes of in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) among polycystic ovarian syndrome (PCOS) and non-PCOS patients. Methods: This was a retrospective cohort study that was performed in the Second Hospital of Hebei Medical University. Patients who were under 35 years old were included in the study and were divided into four groups based on their BMI. The number of retrieved oocytes, implantation rate, clinical pregnancy rate, miscarriage rate and live births among PCOS and non-PCOS patients were compared between different BMIs. Results: IVF/ICSI pregnancies in obese PCOS women had a considerably higher risk of miscarriage and low rate of clinical pregnancy than in non-obese PCOS pregnancies. However, in non-PCOS patient, obesity significantly elevated miscarriage rate but did not affect clinical pregnancy rate. Conclusion: Obesity in PCOS patients led to poor outcomes of IVF/ICSI.


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