scholarly journals Teriparatide for the rapid resolution of delayed healing of atypical fractures associated with long-term bisphosphonate use

2016 ◽  
Vol 3 (2) ◽  
pp. 87-90 ◽  
Author(s):  
Silvina R. Mastaglia ◽  
Gabriel Aguilar ◽  
Beatriz Oliveri
Keyword(s):  
Rapid Resolution ◽  
Atypical Fractures ◽  
Delayed Healing

scholarly journals Acute Nontraumatic Clavicle Fracture Associated with Long-Term Bisphosphonate Therapy

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Shen Hwa Vun ◽  
Yahya Husami ◽  
Sajan Shareef ◽  
Diane Bramley
Keyword(s):  
Clavicle Fracture ◽  
Critical Evaluation ◽  
Osteonecrosis Of The Jaw ◽  
Bisphosphonate Therapy ◽  
Low Energy ◽  
Insufficiency Fractures ◽  
Atypical Fractures

Cases of osteonecrosis of the jaw, insufficiency fractures and atypical low energy or atraumatic fractures of pelvis, femur (subtrochanteric/mid-shaft/distal-third), tibia, fibula, metatarsal, humerus, and ulna related to long-term bisphosphonate therapy have been reported in the literature. We present the case of an acute nontraumatic clavicle fracture, associated with long-term bisphosphonate therapy, which to our knowledge has not been reported previously. This case highlights the need of critical evaluation of patients with atypical fractures during long-term bisphosphonate therapy.

scholarly journals Antiresorptive-associated spontaneous fractures of both tibiae, followed by an atypical femur fracture during the sequential treatment with alendronate, denosumab then teriparatide

2019 ◽  
Vol 12 (7) ◽  
pp. e229366 ◽  
Author(s):  
Juan Tan ◽  
Hiroshige Sano ◽  
Kenneth Poole
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Femur Fracture ◽  
Bisphosphonate Therapy ◽  
Antiresorptive Therapy ◽  
Atypical Fracture ◽  
Atypical Femur Fracture ◽  
Atypical Fractures ◽  
Alendronate Treatment ◽  
Careful Investigation

A 35-year-old man with juvenile idiopathic arthritis since childhood presented with bilateral atypical tibial fractures, followed by a later, single atypical fracture of the femur. The fractures were associated with 6 years of oral alendronate treatment immediately followed by subcutaneous denosumab therapy and later teriparatide therapy for osteoporosis. Atypical fractures are known to occur in the femur following bisphosphonate therapy; however, there are only a few documented cases of atypical fractures in the tibia. Our case highlights a rare but serious complication of a commonly prescribed antiresorptive agent. It also shows that teriparatide, while helpful in increasing bone mass, does not fully prevent the development of atypical fractures. Careful investigation should be considered in patients on long-term antiresorptive therapy presenting with bony tenderness to exclude an atypical fracture.

Follow-Up of Atypical Fractures Associated with Long-Term Bisphosphonate Therapy: A Case Series

2011 ◽  
pp. P1-232-P1-232
Author(s):  
Francisco Antonio Padilla ◽  
Ansu Varughese Joy ◽  
Pamela Taxel ◽  
Faryal Mirza ◽  
Lisanne Cirullo
Keyword(s):  
Case Series ◽  
Bisphosphonate Therapy ◽  
Atypical Fractures

Risk factors for delayed healing and long-term recurrence in chronic venous leg ulcers

2000 ◽  
Vol 87 (4) ◽  
pp. 501-501
Author(s):  
J. R. Barwell ◽  
M. Taylor ◽  
A. S. K. Ghauri ◽  
C. Bronder ◽  
L. Phillips ◽  
...  
Keyword(s):  
Risk Factors ◽  
Leg Ulcers ◽  
Venous Leg Ulcers ◽  
Delayed Healing

scholarly journals Assessment of Bone Microarchitecture in Postmenopausal Women on Long-Term Bisphosphonate Therapy With Atypical Fractures of the Femur

2014 ◽  
Vol 29 (4) ◽  
pp. 999-1004 ◽  
Author(s):  
Maria Belen Zanchetta ◽  
Maria Diehl ◽  
Mirena Buttazzoni ◽  
Ana Galich ◽  
Fernando Silveira ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Bone Microarchitecture ◽  
Bisphosphonate Therapy ◽  
Atypical Fractures ◽  
Fractures Of The Femur

scholarly journals Bisphosphonates and Atypical Fractures of Femur

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Tero Yli-Kyyny
Keyword(s):  
Task Force ◽  
Case Reports ◽  
Term Treatment ◽  
Mineral Research ◽  
Task Force Report ◽  
Treatment Of Osteoporosis ◽  
Atypical Fractures ◽  
Long Term Treatment ◽  
American Society

Bisphosphonates are the most widely prescribed medicines for the treatment of osteoporosis and have generally been regarded as well-tolerated and safe drugs. Since 2005, there have been numerous case reports about atypical fractures of the femur linked to long-term treatment of osteoporosis with bisphosphonates. Some attempts to characterize pathophysiology and epidemiology of these fractures have been published as well. However, as the American Society for Bone and Mineral Research (ASBMR) concluded in their task force report, the subject warrants further studies.

scholarly journals Risk factors for a delayed course of reparative processes after destructive intervention on the integumentary tissues of the foot

2021 ◽  
Author(s):  
А.А. Кубанов ◽  
Е.К. Мураховская ◽  
Р.Н. Комаров ◽  
А.Н. Дзюндзя ◽  
И.А. Винокуров
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Clinical Observation ◽  
Lower Extremities ◽  
Arterial Disease ◽  
Lower Limbs ◽  
Delayed Healing ◽  
Healing Wounds ◽  
Arterial Insufficiency

В статье обобщены сведения о заболеваниях и состояниях, оказывающих влияние на процессы нормального заживления после деструктивных вмешательств на покровных тканях стопы, представлены современные данные литературы, посвященные этим вопросам. Неадекватная оценка состояния пациента перед проведением планового деструктивного вмешательства на нижних конечностях может привести к формированию длительно незаживающего раневого дефекта и нарушению функции конечности. Проведение деструктивного вмешательства требует настороженности в отношении ряда заболеваний и состояний, влияющих на процессы нормального заживления, таких как сахарный диабет, метаболический синдром, иммунодефицит. Особое внимание в статье уделено оценке состоятельности кровотока нижних конечностей в связи с тем, что хроническая артериальная недостаточность является одной из наиболее значимых причин замедленного течения репаративных процессов в области стоп. Представлено собственное клиническое наблюдение, иллюстрирующее отсутствие нормальной регенерации в условиях гипергликемии и хронической артериальной недостаточности нижних конечностей. The article summarizes information about diseases and conditions that affect the processes of normal healing after destructive interventions on the integumentary tissues of the foot, presents modern literature data on these issues. An inadequate assessment of the patient's condition before a planned destructive intervention on the lower extremities can lead to a long-term non-healing wounds and dysfunction of the extremity. A destructive intervention requires attention to a number of diseases and conditions that affect normal healing processes, such as diabetes mellitus, metabolic syndrome, and immunodeficiency. Particular attention is paid to the assessment of the consistency of the blood flow of the lower extremities because chronic arterial insufficiency is one of the most significant reasons for the slow reparative processes in the foot area. The authors present their own clinical observation that illustrates the absence of normal regeneration in conditions of hyperglycemia and chronic arterial disease of the lower limbs. Keywords: destruction, destructive interventions, atherosclerosis, wound healing, regeneration, chronic arterial insufficiency, lower limbs, delayed healing.

Panmetatarsal head resection. A viable alternative to the transmetatarsal amputation

1993 ◽  
Vol 83 (2) ◽  
pp. 101-107 ◽  
Author(s):  
JM Giurini ◽  
P Basile ◽  
JS Chrzan ◽  
GM Habershaw ◽  
BI Rosenblum
Keyword(s):  
Local Recurrence ◽  
Retrospective Review ◽  
Viable Alternative ◽  
Delayed Healing ◽  
Short And Long Term ◽  
Transmetatarsal Amputation ◽  
Primary Healing

While the transmetatarsal amputation has resulted in the salvage of numerous diabetic limbs, it remains an ablative procedure with both short- and long-term complications. The authors reviewed their experience with the panmetatarsal head resection as an alternative to the transmetatarsal amputation. A retrospective review was performed of all patients having undergone this procedure between May 1986 and November 1991. Thirty-seven procedures were performed; of these, 34 were evaluated. The average follow-up period was 20.9 months. Thirty-two feet showed primary healing while one showed delayed healing. One patient had local recurrence of the original ulceration. Primary healing was 94% while overall success was 97%. No patient required amputation of any kind. The authors conclude that the panmetatarsal head resection is a viable alternative to the transmetatarsal amputation in properly selected patients because it avoids many of the structural and biomechanical pitfalls of the transmetatarsal amputation.

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