Effects of Oxygen Therapies in Experimental Acute Acoustic Trauma

IntroductionAcute acoustic trauma (AAT) is a sensorineural hearing impairment due to exposure to an intense impulse noise which causes cochlear hypoxia. Hyperbaric oxygen therapy (HBO) could provide an adequate oxygen supply. The aim was to investigate the effectiveness of early treatment with combined HBO and corticosteroid therapy in patients with AAT compared with corticosteroid monotherapy.MethodsA retrospective study was performed on military personnel diagnosed with AAT between November 2012 and December 2017. Inclusion criteria for HBO therapy were hearing loss of 30 dB or greater on at least one, 25 dB or more on at least two, or 20 dB or more on three or more frequencies as compared with the contralateral ear.ResultsAbsolute hearing improvements showed significant differences (independent t-test) between patients receiving HBO and the control group at 500 Hz (p=0.014), 3000 Hz (p=0.023), 4000 Hz (p=0.001) and 6000 Hz (p=0.01) and at the mean of all frequencies (p=0.002). Relative hearing improvements were significantly different (independent t-test) at 4000 Hz (p=0.046) and 6000 Hz (p=0.013) and at all frequencies combined (p=0.005). Furthermore, the percentage of patients with recovery to the functional level required by the Dutch Armed Forces (clinical outcome score) was higher in the HBO group.ConclusionsEarly-stage combination therapy for patients with AAT was associated with better audiometric results at higher frequencies and better clinical outcome score.

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Acute acoustic trauma in the French armed forces during 2007–2014

Noise and Health ◽

10.4103/1463-1741.195802 ◽

2016 ◽

Vol 18 (85) ◽

pp. 297 ◽

Cited By ~ 3

Author(s):

DorisR Medina-Garin ◽

Aissata Dia ◽

Gabriel Bedubourg ◽

Xavier Deparis ◽

Franck Berger ◽

...

Keyword(s):

Armed Forces ◽

Acoustic Trauma ◽

Acute Acoustic Trauma

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Comparison of the Protective Effects of Radix Astragali, α-Lipoic Acid, and Vitamin E on Acute Acoustic Trauma

Clinical Medicine Insights Ear Nose and Throat ◽

10.4137/cment.s10711 ◽

2012 ◽

Vol 5 ◽

pp. CMENT.S10711 ◽

Cited By ~ 8

Author(s):

Min Xiong ◽

Huangwen Lai ◽

Chuanhong Yang ◽

Weiyi Huang ◽

Jian Wang ◽

...

Keyword(s):

Hearing Loss ◽

Vitamin E ◽

Lipoic Acid ◽

Impulse Noise ◽

Cell Damage ◽

Acoustic Trauma ◽

Protective Effects ◽

Radix Astragali ◽

Hair Cell Damage ◽

Acute Acoustic Trauma

Objective Oxidative damage is a critical role which involves hearing loss induced by impulse noise. That exogenous antioxidant agents reduce noise induced hearing loss (NIHL) has been well demonstrated in both animal studies and clinical practices. Choosing a stronger and more effective antioxidant is very important for treatment of NIHL. Vitamin E, α-lipoic acid, and radix astragali are the most commonly used anti-oxidants for cochlear oxidative damage from acoustic trauma. In this study, the protective effects of radix astragali, α-lipoic acid, and vitamin E on acute acoustic trauma are investigated. Methods Guinea pigs in the experimental groups were intragastrically administered vitamin E, α-lipoic acid, and radix astragali. Auditory thresholds were assessed by sound-evoked auditory brainstem response (ABR) at click and tone bursts of 8, 16 and 32 kHz, 24 hours before and 72 hours after exposure to impulse noise. Cochlear malondialdehyde (MDA) concentrations were detected. Hair cell damage was analyzed by scanning electron microscopy. Results Vitamin E, α-lipoic acid, and radix astragali significantly reduced ABR deficits, reduced hair cell damage, and decreased the concentrations of MDA. α-lipoic acid and radix astragali were better than vitamin E, and there were no significant differences between α-lipoic acid and radix astragali. Conclusions α-lipoic acid or radix astragali are recommended for treatment of NIHL.

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Negative Effect of Immediate Hyperbaric Oxygen Therapy in Acute Acoustic Trauma

Otology & Neurotology ◽

10.1097/01.mao.0000224080.77849.3d ◽

2006 ◽

Vol 27 (4) ◽

pp. 478-483 ◽

Cited By ~ 8

Author(s):

Burak Ömür Çakir ◽

Ibrahim Ercan ◽

Şenol Civelek ◽

Şefika Körpinar ◽

Akýn Savaş Toklu ◽

...

Keyword(s):

Hyperbaric Oxygen ◽

Hyperbaric Oxygen Therapy ◽

Oxygen Therapy ◽

Acoustic Trauma ◽

Negative Effect ◽

Acute Acoustic Trauma

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A Randomized, Double-blind, Placebo-controlled Study of Dextran/Pentoxifylline Medication in Acute Acoustic Trauma and Sudden Hearing Loss

Acta Oto-Laryngologica ◽

10.3109/00016489209137424 ◽

1992 ◽

Vol 112 (3) ◽

pp. 435-443 ◽

Cited By ~ 78

Author(s):

Rudolf Probst ◽

Kurt Tschopp ◽

Eric Lodin ◽

Bernhard Kellerhals ◽

Michael Podvinec ◽

...

Keyword(s):

Hearing Loss ◽

Sudden Hearing Loss ◽

Acoustic Trauma ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo ◽

Acute Acoustic Trauma

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The effects of noise during recovery from an acute acoustic trauma

The Journal of the Acoustical Society of America ◽

10.1121/1.417717 ◽

1996 ◽

Vol 100 (4) ◽

pp. 2627-2627

Author(s):

William A. Ahroon ◽

Roger P. Hamernik

Keyword(s):

Acoustic Trauma ◽

Acute Acoustic Trauma

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Hsp70/Bmi1-FoxO1-SOD Signaling Pathway Contributes to the Protective Effect of Sound Conditioning against Acute Acoustic Trauma in a Rat Model

Neural Plasticity ◽

10.1155/2020/8823785 ◽

2020 ◽

Vol 2020 ◽

pp. 1-22

Author(s):

Guoxia Zhu ◽

Yongxiang Wu ◽

Yang Qiu ◽

Keyong Tian ◽

Wenjuan Mi ◽

...

Keyword(s):

Protective Effect ◽

Signaling Pathway ◽

Rat Model ◽

Molecular Mechanisms ◽

Outer Hair Cell ◽

Acoustic Trauma ◽

Auditory Brainstem Responses ◽

Ultrastructural Changes ◽

Ganglion Neurons ◽

Acute Acoustic Trauma

Sound conditioning (SC) is defined as “toughening” to lower levels of sound over time, which reduces a subsequent noise-induced threshold shift. Although the protective effect of SC in mammals is generally understood, the exact mechanisms involved have not yet been elucidated. To confirm the protective effect of SC against noise exposure (NE) and the stress-related signaling pathway of its rescue, we observed target molecule changes caused by SC of low frequency prior to NE as well as histology analysis in vivo and verified the suggested mechanisms in SGNs in vitro. Further, we investigated the potential role of Hsp70 and Bmi1 in SC by targeting SOD1 and SOD2 which are regulated by the FoxO1 signaling pathway based on mitochondrial function and reactive oxygen species (ROS) levels. Finally, we sought to identify the possible molecular mechanisms associated with the beneficial effects of SC against noise-induced trauma. Data from the rat model were evaluated by western blot, immunofluorescence, and RT-PCR. The results revealed that SC upregulated Hsp70, Bmi1, FoxO1, SOD1, and SOD2 expression in spiral ganglion neurons (SGNs). Moreover, the auditory brainstem responses (ABRs) and electron microscopy revealed that SC could protect against acute acoustic trauma (AAT) based on a significant reduction of hearing impairment and visible reduction in outer hair cell loss as well as ultrastructural changes in OHCs and SGNs. Collectively, these results suggested that the contribution of Bmi1 toward decreased sensitivity to noise-induced trauma following SC was triggered by Hsp70 induction and associated with enhancement of the antioxidant system and decreased mitochondrial superoxide accumulation. This contribution of Bmi1 was achieved by direct targeting of SOD1 and SOD2, which was regulated by FoxO1. Therefore, the Hsp70/Bmi1-FoxO1-SOD signaling pathway might contribute to the protective effect of SC against AAT in a rat model.

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