scholarly journals HOXA11 and MMP2 gene expression in uterosacral ligaments of women with pelvic organ prolapse

2014 ◽  
Vol 15 (2) ◽  
pp. 104-108 ◽  
Author(s):  
Nafiye Yilmaz ◽  
Gulnur Ozaksit ◽  
Yunus Kasim Terzi ◽  
Saynur Yilmaz ◽  
Burcu Budak ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pelvic Organ Prolapse ◽  
Pelvic Organ ◽  
Uterosacral Ligaments

scholarly journals Identification of Key Genes Involved in the Pathogenesis of Recurrent Pelvic Organ Prolapse Using Bioinformatics Analysis

2021 ◽  
Author(s):  
Ling Zhu ◽  
Xiaoling Ni ◽  
Shanshan Tang ◽  
Wenhua Liu
Keyword(s):  
Gene Expression ◽  
Pelvic Organ Prolapse ◽  
Immune Cell ◽  
Differential Expression Analysis ◽  
Pelvic Organ ◽  
Functional Enrichment ◽  
Hub Genes ◽  
Network Analyses ◽  
Uterosacral Ligaments ◽  
Key Genes

Abstract Background: The causes of the recurrence of pelvic organ prolapse (POP) are sufficiently understood. However, few studies investigate the key genes of recurrence POP. The present study aimed to screen the hub genes of recurrence POP. Microarray data of 4 recurrent POP and 4 primary POP uterosacral ligaments in the GSE28660 gene expression dataset were used as research objects. we used the online Gene Expression Omnibus (GEO) microarray expression profiling dataset to identify differentially expressed genes (DEGs). Also, functional enrichment and protein-protein interaction (PPI) network analyses were performed, and the key modules were identified. Then, we investigated the differential immune cell infiltration between recurrent POP and primary POP tissues using the CIBERSORT algorithm.Results: In total, 84 upregulated and 32 downregulated genes were identified in the differential expression analysis.Conclusion: This human genome DNA microarrays analysis identified a recurrence POP signature of 116 genes, and 2 hub genes, including cell death-inducing DFFA-like effector (CIDEA) and hemoglobin subunit delta (HBD) may participate in the pathogenesis of recurrence POP, giving them a certain diagnostic and therapeutic value.

scholarly journals Elastin Expression in Sacrouterina Ligament is Weaker in the Women with Pelvic Organ Prolapse

2016 ◽  
Author(s):  
Andi Hasnawati
Keyword(s):  
Pelvic Organ Prolapse ◽  
Pelvic Organ ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
School Of Medicine ◽  
Uterosacral Ligaments ◽  
The Cross

Objective: The research aims at comparing the elastin immunolabeling in the uterosacral ligaments in women with pelvic organ prolapse and without pelvic organ prolapse (POP). Methods: The research is done at Dr. Wahidin Sudirohusodo Hospital and education networking some hospitals the Obstetrics and Gynecological School of Medicine Hasanuddin University that began in January 2011 until April 2012. This research assessing expression of elastin on 35 women with a pop level III and IV and as control is 35 women without POP. Immunolabeling of elastin valued in staining checkings immunohistokimia uses antibodies elastin ( clone no. Ba-4 1:1600; Novacastra Laboratories Ltd, UK). The research was carried out by the cross sectional study. Mixed with chi-square. Level significance used is 0.05. Results: The results showed that the elastin immunolabeling in women with POP is decline on most sample expression with the intensity of elastin is weak (74.3%). The most control with the intensity of elastin immunolabeling is moderate (48.6%). Elastin immunolabeling seem significant in women with menopause and with BMI that overweight (all with p

Laparoscopic duplication of the uterosacral ligaments following hysterectomy for stage III–IV apical pelvic organ prolapse

2019 ◽  
Vol 72 (1) ◽  
pp. 199-204 ◽  
Author(s):  
Maurizio Serati ◽  
Antonio Simone Laganà ◽  
Jvan Casarin ◽  
Baldo Gisone ◽  
Simona Cantaluppi ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Pelvic Organ ◽  
Stage Iii ◽  
Uterosacral Ligaments

scholarly journals Using the novel pelvic organ prolapse histologic quantification system to identify phenotypes in uterosacral ligaments in women with pelvic organ prolapse

2021 ◽  
Vol 224 (1) ◽  
pp. 67.e1-67.e18 ◽  
Author(s):  
David J. Orlicky ◽  
Marsha K. Guess ◽  
Elise S. Bales ◽  
Lauren G. Rascoff ◽  
Jaime S. Arruda ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Pelvic Organ ◽  
The Novel ◽  
Uterosacral Ligaments
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